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Low MRE11 expression is associated with B-cell lymphomas.
cyclin A2 (显示 CCNA2 ELISA试剂盒) controlled Mre11 abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 transcripts to mediate polysome loading and translation.
MRE11 complex influences the elimination of oocytes with unrepaired meiotic double-strand breaks post-natally, in addition to its previously described role in double-strand break repair and homologous synapsis during female meiosis.
Inhibiting MRE11 by mirin during meiotic maturation results in anaphase bridges and also increases the number of gammaH2AX (显示 H2AFX ELISA试剂盒) foci in metaphase II. Compromised DNA integrity in mirin-treated oocytes indicates a role for MRE11 in chromosome integrity during meiotic maturation.
The authors demonstrate that ATM (显示 ATM ELISA试剂盒) can be activated by DNA double-strand breaks in the absence of the Mre11-Rad50 (显示 RAD50 ELISA试剂盒)-NBS1 (显示 NBN ELISA试剂盒) (MRN) sensor complex.
TRIP13 (显示 TRIP13 ELISA试剂盒)-deficient spermatocytes also progress to an H1t (显示 HIST1H1T ELISA试剂盒)-positive stage if ATM (显示 ATM ELISA试剂盒) activity is attenuated by hypomorphic mutations in Mre11 or Nbs1 (显示 NBN ELISA试剂盒) or by elimination of the ATM (显示 ATM ELISA试剂盒)-effector kinase CHK2 (显示 CHEK2 ELISA试剂盒)
Impairment of Mre11 complex functions promotes the progression of mammary hyperplasias into invasive and metastatic breast cancers
results suggest that the MRE11-RAD50 (显示 RAD50 ELISA试剂盒) complex plays important roles in recognition of dsDNA and initiation of STING-dependent signaling, in addition to its role in DNA-damage responses
The critical role of the MRE11 GAR motif in DSB repair is a mechanistic link between post-translational modifications at the MRE11 GAR motif and DSB processing, as well as the ATR (显示 ATR ELISA试剂盒)/CHK1 (显示 CHEK1 ELISA试剂盒) checkpoint signaling.
Mre11 is present in mitochondria where it binds to mtDNA and that the amount in mitochondria varies depending on cellular stress and differentiation.
Mre11-Rad50 (显示 RAD50 ELISA试剂盒)-Nbs1 (显示 NBN ELISA试剂盒) complex initiates DNA double strand break repair.
we show that Plk1 (显示 PLK1 ELISA试剂盒) phosphorylates Mre11 at S649 during G2 DNA damage recovery and Mre11 phosphorylation at S649/S689 drives premature checkpoint termination and reduced DNA repair
In the absence of RAD51 (显示 RAD51 ELISA试剂盒), the unprotected newly replicated genome is degraded by the exonuclease (显示 EXO1 ELISA试剂盒) activity of MRE11, and the fragmented nascent DNA accumulates in the cytosol, initiating an innate immune response.
Both the genome instability and cell death of MRE11-null and MRE11-mutated H129N cells are significantly reversed by overexpression of Tdp2 (显示 TDP2 ELISA试剂盒), an enzyme that eliminates covalent Top2 (显示 TOP2A ELISA试剂盒) conjugates; thus, the essential role of Mre11 nuclease (显示 DCLRE1C ELISA试剂盒) activity is likely to remove the DNA lesions.
The results illuminate the important role of Nbs1 (显示 NBN ELISA试剂盒) and CtIP (显示 RBBP8 ELISA试剂盒) in determining the substrates and consequences of human Mre11/Rad50 (显示 RAD50 ELISA试剂盒) nuclease (显示 DCLRE1C ELISA试剂盒) activities on protein-DNA lesions.
Cdk-dependent phosphorylation of TRF1 on threonine 371 promotes TRF1 to interact with APBs in S and G2 phases independently of its binding to telomeric DNA. We have demonstrated that the interaction of (pT371)TRF1 with APBs is dependent upon ATM and homologous-recombination-promoting factors such as Mre11 and BRCA1.
Ataxia-telangiectasia-like disease (A-TLD (显示 BMP1 ELISA试剂盒)) is clinically similar to mild Ataxia-telangiectasia and caused by hypomorphic mutations in the MRE11 gene.
although Mre11 is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.
The aim of this study was to assess the interaction between MRE11 and clinicopathologic variables in breast cancer.
The high expression of MRE11-RAD50 (显示 RAD50 ELISA试剂盒)-NBS1 (显示 NBN ELISA试剂盒) complex constituents could be a predictor for poor prognosis and chemoresistance in gastric cancer
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog\; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
meiotic recombination 11 homolog A
, MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
, MRE11 homolog 1
, MRE11 homolog A
, double-strand break repair protein MRE11A
, meiotic recombination 11 homolog 1
, AT-like disease
, DNA recombination and repair protein
, endo/exonuclease Mre11
, meiotic recombination 11-like protein