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BRCA2 (BRCA2) ELISA试剂盒产品概述

Full name:
Breast Cancer 2, Early Onset ELISA试剂盒 (BRCA2)
在www.antibodies-online.cn可供25 Breast Cancer 2, Early Onset (BRCA2) ELISA试剂盒的7不同的供货商。 再加上,我们可以发BRCA2 抗体 (87)BRCA2 蛋白 (2)和数多这个蛋白质的别的产品。 总共117 BRCA2产品已列进来了。
别名:
AI256696, AW045498, BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2, RAB163
list all ELISA KIts 基因 基因ID UniProt
BRCA2 12190 P97929
BRCA2 675 P51587
BRCA2 360254  

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适于 BRCA2 相互作用对的更多 ELISA 试剂盒

Zebrafish Breast Cancer 2, Early Onset (BRCA2) interaction partners

  1. Carcinogenesis in zebrafish with combined mutations in tp53 (显示 TP53 ELISA试剂盒) and brca2 typically requires biallelic mutation or loss of at least one of these genes.

  2. The novel role of Brca2 in organizing the vertebrate egg nucleus may provide new insights into the origin of ovarian cancer

  3. critical roles for brca2 in ovarian development and tumorigenesis in reproductive tissues

Mouse (Murine) Breast Cancer 2, Early Onset (BRCA2) interaction partners

  1. we describe a genetic approach to examine the functional significance of the interaction between BRCA2 and PALB2 (显示 PALB2 ELISA试剂盒) by generating a knock-in mouse model of Brca2 carrying a single amino acid change (Gly25Arg, Brca2G25R) that disrupts this interaction. In addition, we have combined Brca2G25R homozygosity as well as hemizygosity with Palb2 (显示 PALB2 ELISA试剂盒) and Trp53 (显示 TP53 ELISA试剂盒) heterozygosity .

  2. Merit40 (显示 BABAM1 ELISA试剂盒) mutation exacerbated ICL-induced chromosome instability in the context of concomitant Brca2 deficiency but not in conjunction with Fancd2 (显示 FANCD2 ELISA试剂盒) mutation.

  3. Heterozygous and homozygous Brca2 mutation may lead to dysfunction in T cell populations.

  4. BRCA2 exon 27 domain maintains chromosomal integrity at both stalled and collapsed replication forks consistent with involvement in both replication fork maintenance and double strand break repair.

  5. we use a genetically engineered mouse model of BRCA2-associated hereditary breast cancer to study drug resistance to several types of chemotherapy and PARP (显示 PARP1 ELISA试剂盒) inhibition.

  6. BRCA2-mediated sequestration of nuclear RAD51 (显示 RAD51 ELISA试剂盒) serves to prevent inappropriate DNA interactions.

  7. BRCA2 directly represses the expression of IFN-related genes

  8. the models reveal novel aspects of cancer evolution in carriers of germline BRCA2 mutations, provide new insights into the tumour suppressive role of BRCA2

  9. genetic stability, and hematopoietic differentiation potential of gene-corrected Brca2(Delta) (27/) (Delta) (27) iPSCs, achievements and limitations in the application of current reprogramming approaches in hematopoietic stem cell therapy are also discussed.

  10. Results suggest that cellular levels of Brca2 and Rad51 (显示 RAD51 ELISA试剂盒) are mutually dependent on each other, and that low levels of these proteins provide selective pressure for reduction of p53 (显示 TP53 ELISA试剂盒), which permits cell growth

Human Breast Cancer 2, Early Onset (BRCA2) interaction partners

  1. Study suggests an increased risk of leukaemia in women with a BRCA2 mutation who receive chemotherapy for breast cancer.

  2. Structure-activity relationship of the peptide binding-motif mediating the BRCA2:RAD51 (显示 RAD51 ELISA试剂盒) protein-protein interaction, is reported.

  3. Data show that there are large differences in the absolute cancer risks between breast cancer 1, early onset protein (BRCA1) and breast cancer 2, early onset protein (BRCA2) mutation carriers with higher vs lower values of the polygenic risk scores (PRS).

  4. Studies indicate almost 20% of women with high-grade serous ovarian cancer are now recognized to harbour a germ line BRCA mutation, and of these, >40% might not have a family history of cancer and would not have received BRCA1 and BRCA2 testing.

  5. BRCA2 mutation is associated with pancreatic cancer.

  6. we describe a genetic approach to examine the functional significance of the interaction between BRCA2 and PALB2 (显示 PALB2 ELISA试剂盒) by generating a knock-in mouse model of Brca2 carrying a single amino acid change (Gly25Arg, Brca2G25R) that disrupts this interaction. In addition, we have combined Brca2G25R homozygosity as well as hemizygosity with Palb2 (显示 PALB2 ELISA试剂盒) and Trp53 (显示 TP53 ELISA试剂盒) heterozygosity .

  7. The Single-molecule molecular inversion probes (smMIP)-based genetic testing enables automated and reliable analysis of the coding sequences of BRCA2.

  8. the purified RAD51 (显示 RAD51 ELISA试剂盒) G151D protein directly and significantly enhances DNA strand exchange activity in the presence of RPA (显示 RPA1 ELISA试剂盒). In concordance with this result, co-incubation of G151D with BRCA2 resulted in a much higher level of strand-exchange activity compared to WT RAD51 (显示 RAD51 ELISA试剂盒). Strikingly, the RAD51 (显示 RAD51 ELISA试剂盒) G151D variant confers resistance to multiple DNA damaging agents, including ionizing radiation, mitomycin C, and doxorubicin.

  9. BRCA2 Mutations are associated with Aggressive Prostate Tumors.

  10. 22 different BRCA2 uncertain significance were detected and p.M784V in BRCA2 was the most common uncertain significance.

BRCA2 抗原简介

Antigen Summary

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Alternative names and synonyms associated with BRCA2

  • breast cancer 2, early onset (BRCA2) Elisa Kit
  • breast cancer 2, early onset (brca2) Elisa Kit
  • breast cancer 2 (Brca2) Elisa Kit
  • breast cancer 2, early onset (Brca2) Elisa Kit
  • AI256696 Elisa Kit
  • AW045498 Elisa Kit
  • BRCA2 Elisa Kit
  • BRCC2 Elisa Kit
  • BROVCA2 Elisa Kit
  • FACD Elisa Kit
  • FAD Elisa Kit
  • FAD1 Elisa Kit
  • FANCB Elisa Kit
  • FANCD Elisa Kit
  • FANCD1 Elisa Kit
  • GLM3 Elisa Kit
  • PNCA2 Elisa Kit
  • RAB163 Elisa Kit

Protein level used designations for BRCA2

breast and ovarian cancer susceptibility protein 2 , breast cancer 2, early onset , breast cancer type 2 susceptibility protein-like , breast cancer type 2 susceptibility protein homolog , fanconi anemia group D1 protein homolog , BRCA1/BRCA2-containing complex, subunit 2 , breast and ovarian cancer susceptibility gene, early onset , breast cancer 2 tumor suppressor , breast cancer type 2 susceptibility protein , fanconi anemia group D1 protein , truncated breast and ovarian cancer susceptibility protein 2 , breast cancer 2, mutation 1, University of Wisconsin-Madison , breast cancer susceptibility protein 2

GENE ID SPECIES
100064578 Equus caballus
566758 Danio rerio
584780 Strongylocentrotus purpuratus
721981 Macaca mulatta
100397509 Callithrix jacchus
452526 Pan troglodytes
100038818 Xenopus (Silurana) tropicalis
100601625 Nomascus leucogenys
12190 Mus musculus
675 Homo sapiens
360254 Rattus norvegicus
374139 Gallus gallus
474180 Canis lupus familiaris
507069 Bos taurus
493878 Felis catus
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