Use your antibodies-online credentials, if available.
抗Rat (Rattus) 抗体:
抗Mouse (Murine) 抗体:
Human Monoclonal APEX1 Primary Antibody for ChIP, GS - ABIN4889971
Fishel, Seo, Smith, Kelley: Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing. in Cancer research 2003
Show all 77 Pubmed References
Human Polyclonal APEX1 Primary Antibody for BP, ChIP - ABIN151028
Briegert, Kaina: Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents. in Cancer research 2007
Show all 57 Pubmed References
Human Polyclonal APEX1 Primary Antibody for IHC (p), IHC - ABIN257862
Demple, Herman, Chen: Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. in Proceedings of the National Academy of Sciences of the United States of America 1992
Show all 4 Pubmed References
Arabidopsis thaliana Polyclonal APEX1 Primary Antibody for WB - ABIN334581
Kangasjaervi, Lepistoe, Haennikaeinen, Piippo, Luomala, Aro, Rintamaeki: Diverse roles for chloroplast stromal and thylakoid-bound ascorbate peroxidases in plant stress responses. in The Biochemical journal 2008
Show all 7 Pubmed References
Through the characterization of the interactomes of APE1 with RNA and other proteins, we demonstrate here a role for APE1 in pri-miRNA processing and stability via association with the DROSHA (显示 DROSHA 抗体)-processing complex during genotoxic stress. We also show that endonuclease activity of APE1 is required for the processing of miR (显示 MLXIP 抗体)-221/222 in regulating expression of the tumor suppressor PTEN (显示 PTEN 抗体).
Co-localization of AP endonuclease (APE1) with poly(ADP-ribose) polymerase 1 (PARP1 (显示 PARP1 抗体)) on DNA was found capable of inducing 1D diffusion of otherwise nonmotile PARP1 (显示 PARP1 抗体), while excess APE1 also facilitated the dissociation of DNA-bound PARP1 (显示 PARP1 抗体).
the APEX1 Asp148Glu polymorphism might be important in stimulating the development of prostate cancer rather than its invasiveness in various populations, especially for Asians.
our data reinforce the concept that non-synonymous APE1 variants present in the human population may act as cancer susceptibility alleles
Data suggest that APE1 could be a potential target for NSCLC metastasis and AT101 is a potent inhibitor in further treatment of NSCLC patients.
Our findings suggest that constitutive overexpression of APE1 in esophageal adenocarcinoma may be an adaptive pro-survival mechanism that protects against the genotoxic lethal effects of bile reflux episodes.
our study demonstrates that increased acetylation levels of APE1 in tumor cells inhibit the limited N-terminal proteolysis of APE1 and thereby maintain the functions of APE1 to promote tumor cells' sustained proliferation and survival.
Data indicate that apurinic/apyrimidinic endonuclease-1 (APE1) efficiently process an abasic ribonucleoside 5'-monophosphates (rNMPs) site in DNA and have weak endoribonuclease and 3'-exonuclease (显示 EXO1 抗体) activities on r8oxoG substrate.
These results suggested that the expression of APE1 was an important basis for the maintenance of poly (ADP-ribose) polymerase 1 (显示 PARP1 抗体), and the deletion of APE1 may be related to the resistance of triple-negative breast cancer to olaparib.
Alleles in mitochondrial transcription factor A (TFAM (显示 TFAM 抗体)) and AP endonuclease 1 (APE1) are associated with reduced cognitive performance.
Study shows the methylation of the APE1 promoter and its role in mediating the functional effects of redox reactions induced by oxidative stress.
Meiosis progression and female age affect expression profile of DNA repair APEX1 gene in bovine oocytes.
prediction of the 3D structure of bovine AP lyase (BAP1); models of mutants showed substitution of Arg176-->Ala leads to the loss of DNA binding whereas mutation of Asp282-->Ala and His308-->Asn leads to a decrease in the enzymatic activity.
findings provide evidence that endogenous APE1 protects against ischemic infarction in both gray and white matter and facilitates the functional recovery of the central nervous system after mild stroke injury
Suppression of Ape1/Ref-1 redox function leads to an increased cell surface retention of IL-12 (显示 IL12A 抗体) and enhances Th1 (显示 HAND1 抗体) responses.
Is closely associated with upregulation of the Ref1 (显示 THOC4 抗体)/Nrf2 (显示 NFE2L2 抗体) signalling pathway.
Results show the stimulatory effect of PARP-1 (显示 PARP1 抗体) on APE1-dependent base excision repair (BER). PARP-1 (显示 PARP1 抗体) and APE1 appear to have a functional interaction in BER since PARP-1 (显示 PARP1 抗体) can stimulate the strand incision activity of APE1.
increases in APEX1 level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells
Endothelial cell tumor proliferation was found to be dependent on Apex-1 expression.
Expression of OGG1 (显示 OGG1 抗体) and APEX1 was decreased at 3h after last exposure to Aroclor 1254 and only the expression level of APEX1 was recovered at 24-h after, so inhibition of DNA repair can be a potential mode of action of Aroclor 1254 gonadal toxicity.
Data indicate that the endonuclease activity of APE1 is required for class switch recombination (CSR (显示 SCARA3 抗体)).
These results suggest that mitochondrial APE1/Ref-1 is contributed to the protective role to protein kinase C (显示 PKC 抗体)-induced mitochondrial dysfunction in endothelial cells.
Spinal motor neurones down-regulate APE1 upon oxidative stress. This property renders motor neurones susceptible to continuous challenge of oxidative stress in pathological conditions.
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene\; all encode the same protein.
DNA-(apurinic or apyrimidinic site) lyase
, APEX nuclease 1
, APEX nuclease (multifunctional DNA repair enzyme) 1
, AP endonuclease class I
, AP lyase
, apurinic-apyrimidinic endonuclease 1
, apurinic/apyrimidinic (abasic) endonuclease
, deoxyribonuclease (apurinic or apyrimidinic)
, protein REF-1
, redox factor-1
, AP endonuclease 1
, apurinic/apyrimidinic endonuclease 1
, apurinic/apyrimidinic endonuclease
, Apurinic-apyrimidinic endonuclease 1
, Redox factor-1
, APEX nuclease