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Human pluripotent stem cells promote the expression of integrin alpha6beta1, and nuclear localization and inactivation of FAK (显示 PTK2 ELISA试剂盒) to supports stem cell self-renewal.
IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R (显示 IGF1R ELISA试剂盒).
By directly binding to the 3'UTRs of ITGA6 and ITGB1 (显示 ITGB1 ELISA试剂盒), we found miR (显示 MLXIP ELISA试剂盒)-30e-5p to suppress mainly the adhesion of ITGA6 in CRC (显示 CALR ELISA试剂盒) cells to laminin.Taken together, miR (显示 MLXIP ELISA试剂盒)-30e-5p is a novel effector of P53 (显示 TP53 ELISA试剂盒)-induced suppression of migration, invasion and metastasis
The SALL4 (显示 SALL4 ELISA试剂盒) - integrin alpha6 - integrin beta1 network promotes cell migration for metastasis via activation of focal adhesion dynamics in basal-like breast cancer cells.
FACS analysis of primary human Benign Prostatic Hyperplasia tissues confirms expansion of CD49f basal epithelia in patients with Basal cell hyperplasia.
alpha6(high)/CD71 (显示 TFRC ELISA试剂盒)(low) cells give rise to a thicker pluristratified epithelium with lower seeding density and display a low Ki67 (显示 MKI67 ELISA试剂盒) positive cells number, showing that they have reached the balance between proliferation and differentiation.
The A380T Single Nucleotide Polymorphism of the ITGA6 gene was not associated with breast cancer development in the analyzed population of Misiones, Argentina.
Positive Thy1 (显示 THY1 ELISA试剂盒) and CD49f expression is significantly associated with the progression and poor prognosis of chondrosarcoma.
Ahr (显示 AHR ELISA试剂盒) ligand aminoflavone targets breast cancer cells with stem cell-like properties, at least in part by abolishing alpha6-integrin expression.
Platelet-enhanced endothelial colony forming cell angiogenesis requires platelet tetraspanin CD151 (显示 CD151 ELISA试剂盒) and alpha6beta1 integrin signaling.
ITGA6 maintains structural integrity of the kidney collecting system.
Integrin alpha 6 Expression on Microglia Surface and Motility on Laminin Is Up-regulated upon Adenosine Diphosphate Stimulation.
interaction of alpha6beta1 in embryonic stem cells (ECCs) with laminin-1 (显示 LAMA1 ELISA试剂盒) activates alpha6beta1/CD151 (显示 CD151 ELISA试剂盒) signaling which programs ESCs (显示 NR2E3 ELISA试剂盒) toward the endothelial cells lineage fate
Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6, Zak (显示 ZAK ELISA试剂盒), Gpr155, and Mtx2 (显示 MTX2 ELISA试剂盒)) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions.
Immunohistological analysis of the tumors showed that Tie2 (显示 TEK ELISA试剂盒)-dependent a6 gene deletion was associated with reduced tumor vascularization and with reduced infiltration of proangiogenic Tie2 (显示 TEK ELISA试剂盒)-expressing macrophages
CD29 (显示 ITGB1 ELISA试剂盒) and CD49f have a critical role of in mediating cancer metastasis.
NLGN1 (显示 NLGN1 ELISA试剂盒) and alpha6 integrin preferentially colocalize in the mature retinal vessels, whereas NLGN1 (显示 NLGN1 ELISA试剂盒) deletion causes an aberrant VE-cadherin (显示 CDH5 ELISA试剂盒), laminin and alpha6 integrin distribution in vessels
alpha6 integrin is an essential upstream regulator of the IGF-1R (显示 IGF1R ELISA试剂盒) survival pathway that regulates the activity level of caspase-3 (显示 CASP3 ELISA试剂盒) for it to signal differentiation initiation of lens epithelial cells.
Deficiency of integrin alpha(6)beta(4) is modestly but significantly suppressed reporter-gene transduction by papillomaviruses in conditional integrin beta(4 (显示 ITGB4 ELISA试剂盒)) knockout mice.
formation of CD151 (显示 CD151 ELISA试剂盒)-integrin complex was likely to be a prerequisite for CD151 (显示 CD151 ELISA试剂盒)-induced angiogenesis and signaling pathways
Equine herpesvirus type 1 infection significantly decreased the expression of integrin alpha 6 in nasal mucosa epithelial cells.
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
CD49 antigen-like family member F
, integrin alpha-6
, integrin alpha6B
, integrin, alpha 6
, integrin alpha 6
, integrin alpha 6 subunit
, integrin alpha chain, alpha 6
, integrin alpha-6-like