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Our study elucidates the molecular mechanisms of miR (显示 MLXIP ELISA试剂盒)-101/ITGA3 pathway in regulating nasopharyngeal carcinoma (NPC (显示 NPC1 ELISA试剂盒))metastasis and angiogenesis, and the systemic delivery of miR (显示 MLXIP ELISA试剂盒)-101 provides a potent evidence for the development of a novel microRNA-targeting anticancer strategy for NPC (显示 NPC1 ELISA试剂盒) patients.
Results showed that ITGA3 was directly regulated by miR (显示 MLXIP ELISA试剂盒)-199 family in head and neck squamous cell carcinoma cells (HNSCC). Its knockdown significantly inhibited cancer cell migration and invasion by HNSCC cells.
our studies clearly provide evidence that aberrant expression of sFRP2 (显示 SFRP2 ELISA试剂盒) can contribute to the invasive and metastatic potential for osteosarcoma.
Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 and ITGA2B), collagen ( COL5A1 (显示 COL5A1 ELISA试剂盒)), and laminin ( LAMA5 (显示 LAMA5 ELISA试剂盒)) were significantly inhibited by curcumin at messenger RNA and protein levels.
High ITGA3 expression is associated with bladder cancer.
these findings identify CD151 (显示 CD151 ELISA试剂盒) and its interactions with integrins a3 and a6 as potential therapeutic targets for inhibiting stemness-driving mechanisms and stem cell populations in Glioblastoma.
Expression of the alpha3-Integrin splice variants in the brain
the role of the CD151 (显示 CD151 ELISA试剂盒)-alpha3beta1 complex in carcinoma progression is context dependent, and may depend on the mode of tumor cell invasion.
In high grade DCIS, when stratified according to the HER2 (显示 ERBB2 ELISA试剂盒) status, in the HER2 (显示 ERBB2 ELISA试剂盒)-negative subgroup, CD151 (显示 CD151 ELISA试剂盒) assessed in combination with alpha3beta1 was significantly correlated with prognosis.
Data show that CD151 (显示 CD151 ELISA试剂盒) protein (CD151 (显示 CD151 ELISA试剂盒))-alpha3beta1 integrin complexes cooperated with epidermal growth factor receptor (EGFR (显示 EGFR ELISA试剂盒)) to drive tumor cell motility.
formation of CD151 (显示 CD151 ELISA试剂盒)-integrin complex was likely to be a prerequisite for CD151 (显示 CD151 ELISA试剂盒)-induced angiogenesis and signaling pathways
K63-linked polyubiquitination of Akt (显示 AKT1 ELISA试剂盒) plays a previously unrecognized role in integrin alpha3beta1-dependent cell signaling required for ureteric bud development and may represent a novel mechanism whereby integrins regulate signaling pathways.
alpha3beta1-dependent alternative polyadenylation of MMP-9 (显示 MMP9 ELISA试剂盒) mRNA occurs through a signaling pathway that involves extracellular signal-regulated kinase/mitogen-activated protein kinases.
NR1, a novel antioxidant, ameliorated glucose-induced impaired podocyte adhesive capacity and subsequent podocyte depopulation partly through a3b1 integrin upregulation.
These findings demonstrate a prominent role for alpha3beta1 in immortalized/transformed keratinocytes in regulating fibulin-2 (显示 FBLN2 ELISA试剂盒) and other genes that promote matrix remodeling and invasion.
integrin alpha3beta1 has a role in basement membrane stability through fibulin-2 (显示 FBLN2 ELISA试剂盒) induction, both in neonatal skin and in adult wounds
GPR56 (显示 GPR56 ELISA试剂盒) functions together with alpha3beta1 integrin in regulating cerebral cortical development.
Results indicate that the basement membrane extract (BME) embedment of islets can up-regulate the expression of alpha3 integrin and its signal transduction, which may improve islet viability.
During myoblast fusion integrin alpha3 associates with integrin beta1 and ADAM12 (显示 ADAM12 ELISA试剂盒), and also CD9 (显示 CD9 ELISA试剂盒) and CD81 (显示 CD81 ELISA试剂盒).
overexpression of mesangial integrin alpha1 and podocyte vimentin (显示 VIM ELISA试剂盒) and integrin alpha3 may be important features of glomerular Alport disease
The C-terminal region of NELL1 (显示 NELL1 ELISA试剂盒) mediates osteoblastic cell adhesion through integrin alpha3beta1
The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
CD49 antigen-like family member C
, VLA-3 subunit alpha
, antigen identified by monoclonal antibody J143
, galactoprotein B3
, integrin alpha-3
, very late activation protein 3 receptor, alpha-3 subunit
, integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
, integrin alpha 3 subunit
, Galactoprotein B3
, Integrin alpha-3
, integrin alpha 3
, integrin alpha-3-like
, VLA-3 alpha 3
, VLA-3 receptor, alpha 3 subunit