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抗Rat (Rattus) GNA13 抗体:
抗Human GNA13 抗体:
抗Mouse (Murine) GNA13 抗体:
Human Polyclonal GNA13 Primary Antibody for WB - ABIN1537979
Zhang, Xu, Lu, Liu, Liu, Ji, Liu, Ouyang, He: VASP activation via the Gα13/RhoA/PKA pathway mediates cucurbitacin-B-induced actin aggregation and cofilin-actin rod formation. in PLoS ONE 2014
In embryos defective for S1pr2 (显示 S1PR2 抗体)/Galpha13 signaling, endocardial precursors failed to migrate towards the midline, and the presumptive endocardium surrounded the bilaterally-located myocardial cells rather than being encompassed by them.
Gpr56 (显示 GPR56 抗体) regulates oligodendrocyte development via interactions with Galpha12 (显示 GNA12 抗体)/13 and RhoA (显示 RHOA 抗体)
S1pr2 (显示 S1PR2 抗体)/Galpha13 signaling controls myocardial migration by regulating endoderm convergence.
Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.
Findings indicate a tumor suppressive role for G protein subunit alpha 13 (Galpha13) and rhoA (显示 RHOA 抗体) GTP-binding protein (RhoA (显示 RHOA 抗体)) in Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL).
Data (including data from studies using transgenic mice) suggest that R7BP-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit (显示 POLG 抗体) 13)
Upregulation of GNA13 expression increased the proliferation and tumorigenicity of gastric cancer.
Knockdown DDR1 (显示 DDR1 抗体) reversed the effects of Galpha13 knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen.
RGS22 (显示 RGS22 抗体) acts as a tumor suppressor, repressing human pancreatic adenocarcinoma cell migration by coupling to GNA12 (显示 GNA12 抗体)/13.
Galpha13 Switch Region 2 Binds to the Talin Head Domain and Activates alphaIIbbeta3 Integrin in Human Platelets
GNA13 expression in breast cancer cells is regulated by post-transcriptional mechanisms involving miR (显示 MLXIP 抗体)-31.
Data show that N-linked glycosylation of protease-activated receptor-1 (PAR1 (显示 F2R 抗体)) at extracellular loop 2 (ECL2) controls G12 (显示 TCF3 抗体)/13 versus Gq G-proteins coupling specificity in response to thrombin (显示 F2 抗体) stimulation.
Our findings highlight the important role of miR (显示 MLXIP 抗体)-29c in regulating CRC (显示 CALR 抗体) EMT (显示 ITK 抗体) via GSK-3b/b-catenin signaling by targeting GNA13 and PTP4A (显示 PTP4A2 抗体) and provide new insights into the metastatic basis of colorectal cancer
These results place Blk (显示 BLK 抗体) upstream of the p190RhoGAP (显示 GRLF1 抗体)-RhoA (显示 RHOA 抗体) pathway in Galpha13-activated cells, overall representing an opposing signaling module during CXCL12 (显示 CXCL12 抗体)-triggered invasion.
results define Galpha13 as a switch regulator of myofiber reprogramming, implying that modulations of Galpha13 and its downstream effectors in skeletal muscle are a potential therapeutic approach to treating metabolic diseases.
This study demonstrated an almost 100-fold higher agonist sensitivity of the Galpha13 LARG (显示 ARHGEF12 抗体) interaction compared to the Galpha13 activation in the absence of LARG (显示 ARHGEF12 抗体).
GNA13 loss is associated with GC B (显示 NPR2 抗体)-cell persistence, in which impaired apoptosis and ongoing somatic hypermutation may lead to an increased risk of lymphoma development.
Selective inhibition of G12 (显示 TCF3 抗体)/13 signaling in macrophages can augment atheroprotective B-cell populations and ameliorate atherosclerosis.
findings identify a Galpha13-dependent pathway that exerts dual actions in suppressing growth and blocking dissemination of germinal centre B cells that is frequently disrupted in germinal centre B-cell-derived lymphoma
Direct Galpha13 binding to ITGB3 (显示 ITGB3 抗体) cytoplasmic domain regulates integrin outside-in signaling and thrombus formation in platelets.
Galpha (显示 SUCLG1 抗体) 13 is activated in sensory neurons mediated by lysophosphatidylinositol.
Galpha13 binding to VE-cadherin (显示 CDH5 抗体) mediates VE-cadherin (显示 CDH5 抗体) internalization and endothelial barrier disruption and inflammation.
Data indicate that Pyk2 (显示 PTK2B 抗体) is a common signaling effector downstream of both G12 (显示 TCF3 抗体)/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
guanine nucleotide binding protein, alpha 13
, guanine nucleotide-binding protein subunit alpha-13
, Galpha 13a
, Galpha 13b
, G-protein alpha 13b
, guanine nucleotide binding protein (G protein), alpha 13
, guanine nucleotide-binding protein subunit alpha-13-like
, G-protein subunit alpha-13
, g alpha-13