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抗Human KLKB1 抗体:
抗Mouse (Murine) KLKB1 抗体:
抗Rat (Rattus) KLKB1 抗体:
Dog (Canine) Polyclonal KLKB1 Primary Antibody for WB - ABIN2782312
Tang, Yu, Williams, Springman, Jeffery, Sprengeler, Estevez, Sampang, Shrader, Spencer, Young, McGrath, Katz: Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein. in The Journal of biological chemistry 2005
genetic polymorphism is associated with C1 Inhibitor (显示 SERPING1 抗体) deficiency angioedema age of onset in European families
these data indicate that KLKB1 induces inflammatory reactions in human dental tissues via protease-activated receptor 1 (显示 F2R 抗体)
von Willebrand factor (显示 VWF 抗体) activity and concentration of prekallikrein may both be of importance regarding the evolution of thrombus in abdominal aortic aneurysm and possible biomarkers for aneurysm growth.
KLKB1 mRNA expression is a putative molecular biomarker in chronic lymphocytic leukemia.
Genotyping these subjects revealed that the carriers of the minor alleles at the two loci- F12 (显示 F12 抗体) and KLKB1 had a significant association with reduced levels of active plasma renin (显示 REN 抗体).
2 genetic loci (kininogen 1 (显示 KNG1 抗体) and kallikrein (显示 KLK4 抗体) B) influencing key components of the RAAS, consistent with the close interrelation between the kallikrein (显示 KLK4 抗体)-kinin system and the RAAS.
PRCP1 interacts with plasma kallikrein (PK) at multiple sites for PK activation.
FXI (显示 F11 抗体) may have a role in risk of ischemic stroke, but not myocardial infarct; FXII (显示 F12 抗体) and prekallikrein may not have a role in either
plasma kallikrein and FXIa activate pro-HGF (显示 HGF 抗体) in vitro
the effect of kininogen (显示 KNG1 抗体) degradation by human neutrophil elastase (HNE (显示 ELANE 抗体)) on kinin generation by tissue and plasma kallikreins.
Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator (显示 PLAT 抗体) therapy in mice after stroke.
we found that post-ejaculated semen from fertile wild-type males was solidified and the sperm were entrapped in Wnt7aCre/+;Esr1f/f uteri, compared to the watery semen (liquefied) found in Esr1f/f controls.Kallikrein-related peptidases 3 (KLK3 (显示 PSA 抗体)) and other kallikrein (显示 KLK1 抗体)-related peptidases from male prostate glands are responsible for semen liquefaction by cleaving gel-forming proteins
Klkb1(-/-) mice have a novel mechanism for thrombosis protection in addition to reduced contact activation. This pathway arises when bradykinin delivery to vasculature is compromised and mediated by increased receptor Mas (显示 MAS1 抗体), prostacyclin, Sirt1 (显示 SIRT1 抗体), and KLF4 (显示 KLF4 抗体)
Plasma kallikrein deletion prevents occlusive thrombus formation in mice with a minimal role in provoked bleeding.
PKK (显示 RIPK4 抗体) or fXII (显示 F12 抗体) deficiency reduced thrombus formation in both arterial and venous thrombosis models, without an apparent effect on hemostasis.
Data suggest that LGG secreting PSA (显示 NPEPPS 抗体) may activate antigen specific immune responses when instilled intravesically and IL15 (显示 IL15 抗体) could enhance this response.
the prekallikrein gene (Klkb1) is expressed highly in the mammary gland during stromal remodeling periods including puberty and postlactational involution.
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
, plasma kallikrein
, plasma kallikrein heavy chain
, plasma kallikrein light chain
, plasma prekallikrein
, antigen, prostate specific
, fletcher factor
, kallikrein 3, plasma
, kallikrein B, plasma (Fletcher factor) 1
, Plasma kallikrein
, plasma kallikrein-like
, plasma kallikrein B1