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Human Kallikrein 2 ELISA Kit for Sandwich ELISA - ABIN415279
Li, Huang, Zhang, Yang, Zhu, Li: A new method to assay protease based on amyloid misfolding: application to prostate cancer diagnosis using a panel of proteases biomarkers. in Theranostics 2014
glycosylation changes the enzymatic activity of KLK2 in a drastically substrate-dependent manner.
The results indicated that W-hK2 (显示 HK2 ELISA试剂盒) had a defect in cellular trafficking due to its misfolding and that it activated the unfolded protein response, suggesting a mechanism to explain the association of the T allele with higher prostate cancer risk.
miR (显示 MLXIP ELISA试剂盒)-378 was predicted to target both KLK2 and KLK4 (显示 KLK4 ELISA试剂盒) and downregulated levels detected in prostate cancer patients.
The differential regulation of alternative transcripts (using KLK2, KLK3 (显示 KLKB1 ELISA试剂盒) and KLK4 (显示 KLK4 ELISA试剂盒) as models) by androgens and anti-androgens as an indicator of prostate cancers, was investigated.
Structure-function analyses of KLK2 establish the 99-loop as master regulator of its activity.
Predictions based on levels of four kallikrein (显示 KLK4 ELISA试剂盒) markers, including KLK2, in blood distinguish between pathologically insignificant and aggressive disease after radical prostatectomy with good accuracy.
Alteration of cellular junctions in benign prostatic hyperplasia could contribute to the presence of luminal epithelial secreted proteins prostate specific antigen (PSA)2 and and KLK2 in the stromal compartment.
we present the first evidence that KLK2 can also function as an androgen receptor (显示 AR ELISA试剂盒) modulator that may modulate cell growth after the development of castration-resistant prostate cancer
Associations observed in young, healthy men between the seminal plasma and serum concentrations of hK2 and PSA and several genetic variants in KLK2 and KLK3 could be useful to refine models of PSA cutoff values in prostate cancer testing.
Genetic variants at ATF7IP (显示 ATF7IP ELISA试剂盒) and KLK2 contribute to the variance of %fPSA.
This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants.
glandular kallikrein 2
, glandular kallikrein-1
, kallikrein 2, prostatic
, tissue kallikrein-2
, arginine esterase
, LOW QUALITY PROTEIN: kallikrein-2
, kallikrein-related peptidase 2