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Human Complement Factor H ELISA Kit for Sandwich ELISA - ABIN365061
Shi, Zhao, Liu, Zhang, Zhou, Pu: Serum proteomics of methamphetamine addicts and up-regulation of complement factor H related to methamphetamine addiction. in Neuroscience letters 2012
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Human Complement Factor H ELISA Kit for Sandwich ELISA - ABIN414509
Lee, Park, Lee, Park, Shin, Park, Yoo, Cho, Kim, Kim, Namgoong, Lee, Lee, Cho, Han, Kang, Ha, Bae, Kim, Park, Cheong: Atypical hemolytic uremic syndrome: Korean pediatric series. in Pediatrics international : official journal of the Japan Pediatric Society 2015
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Human Complement Factor H ELISA Kit for Sandwich ELISA - ABIN511291
Lönnroth, Oshalim, Lange, Johansson: Interaction Of Proteasomes And Complement C3, Assay Of Antisecretory Factor In Blood. in Journal of immunoassay & immunochemistry 2015
interaction between sialylated Neisseria gonorrhoeae and factor H [factor H]
Results report the molecular cloning and identification of complement factor H and complement factor H-like 1-4 (CFHL1 (显示 CFHR1 ELISA试剂盒)-4) in Danio rerio.
Factor H and Crry (显示 CR1L ELISA试剂盒) are critical for regulating complement activation at distinct anatomic sites within the kidney.
VEGF (显示 VEGFA ELISA试剂盒) inhibition decreases local CFH and other complement regulators in the eye and kidney through reduced VEGFR2 (显示 KDR ELISA试剂盒)/PKC-alpha (显示 PKCa ELISA试剂盒)/CREB (显示 CREB1 ELISA试剂盒) signaling.
environmental factors can drive retinal disease in these mice when linked to complement deficits impairing immune function. Both groups of mice had similar levels of retinal amyloid beta accumulation. Consequently there is no direct link between this and inflammation in Cfh(-/-) mice.
absence of plasma CfH conferred susceptibility to glomerulonephritis
This new understanding of the complicated interactions of CFH in AMD (显示 AMD1 ELISA试剂盒)-like pathology provides an improved foundation for the development of targeted therapies for AMD (显示 AMD1 ELISA试剂盒)
data suggest that altered interactions of Cfh with MDA-modified proteins may be relevant in explaining the effects of the Cfh variant.
Cfh and Cfhr2 (显示 CFHR2 ELISA试剂盒) genes are expressed in the mouse outer retina. Only Cfh mRNA was detected in the retinal pigment epithelium, but no protein.
A spectrum of complement dysregulation was modeled on the APOE4 age related macular degeneration mouse model by crossing these mice to complement factor H knockout (cfh-/-) mice to test the impact of excess complement activation.
Data indicate that co-deficiency of factor H (FH) and MASP-1/MASP-3 (显示 MASP1 ELISA试剂盒) did not ameliorate either the plasma Complement C3 (显示 C3 ELISA试剂盒) (C3) activation or glomerular C3 accumulation in FH-deficient mice.
A2E accumulation altered retinal microglial complement regulation by decreasing complement factor H (and increasing complement factor B (显示 CFB ELISA试剂盒) expression), favoring increased complement activation and lipofuscin deposition in the outer retina.
To our knowledge, this is the first evaluation of the involvement of the CFHR3 (显示 CFHR3 ELISA试剂盒)/CFHR1 (显示 CFHR1 ELISA试剂盒) deletion and age-related macular degeneration in CFH Y402H polymorphism Brazilian patients.
The findings of the present study provide evidence that CFH gene variants and ARMS2 (显示 ARMS2 ELISA试剂盒)/HTRA1 (显示 HTRA1 ELISA试剂盒) genes play a major role in the genetic susceptibility to AMD (显示 AMD1 ELISA试剂盒) in a Greek population. These findings are of direct relevance for disease and help mapping the genetic chart of AMD (显示 AMD1 ELISA试剂盒).
Our results suggest the contribution of all four predicted CFH polymorphisms in age-related macular degeneration (AMD (显示 AMD1 ELISA试剂盒)) susceptibility among the Iranian population. This association with CFH may lead to early detection and new strategies for prevention and treatment of AMD (显示 AMD1 ELISA试剂盒).
Development of polypoidal choroidal vasculopathy (PCV) in the unaffected fellow eye is associated with ARMS2 (显示 ARMS2 ELISA试剂盒) A69S genotype in patients with unilateral PCV.
Identification of rare CFH variant carriers may be important for upcoming complement-inhibiting therapies. Patients with an extensive drusen area, drusen with crystalline appearance, and drusen nasal to the optic disc are more likely to have a rare variant in the CFH gene.
C-reactive protein (显示 CRP ELISA试剂盒) amino acids 35-47 mediate the interaction with complement factor H in lupus nephritis
OCT (显示 Plxna2 ELISA试剂盒) scans revealed lower retinal thickness in patients homozygous for CFH or ARMS2 (显示 ARMS2 ELISA试剂盒), which was caused by a significantly reduced photoreceptor layer. The number and ultrastructure of drusen were also significantly different.
CFH rs1061170 has an important effect on age at onset of MDD in Han Chinese and may therefore be related to early pathogenesis of MDD.
Data suggest that disease-linked mutations in complement factor H (CFH) affect pivotal role of CFH in regulation of complement activation; mutations studied include those linked to atypical hemolytic uremic syndrome and age-related macular degeneration.
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
H factor 1 (complement)
, H factor 2 (complement)
, adrenomedullin binding protein
, age-related maculopathy susceptibility 1
, factor H
, factor H-like 1
, complement regulator factor H
, complement factor H
, complement factor H related protein 3A4/5G4
, protein beta-1-H
, complement component factor H
, complement inhibitory factor H
, platelet complement factor H
, complement factor H L homeolog