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the overall architecture of Dare-C1qAgD is similar to human C1qA, residues involved in C1qBgD, C1qCgD, and CRP (显示 CRP 蛋白) binding are somewhat different while residues involved in IgG binding are not present in zebrafish. The structure gives insight into how human and fish C1qA evolved from an ancestral protein
C1qA globular domain (C1qAgD) was expressed, purified and crystallized.
We, for the first time, identified the associations between C1q gene SNPs and autoimmune thyroid diseases, and our findings suggested that five common SNPs in C1q gene were not associated with autoimmune thyroid diseases susceptibility in Chinese Han population
exposure of neural stem cells to neutrophil-synthesized concentrations of C1q and C3a (显示 C3 蛋白) promoted astrogliogenesis and cell migration
this studies show binding of VWF (显示 VWF 蛋白) to C1q and thus a direct interaction between starter molecules of hemostasis and the classical pathway of complement
Cerebrospinal fluid (CSF (显示 CSF2 蛋白)) soluble complement receptor 2 (sCR2 (显示 RBMS1 蛋白)) levels correlated significantly both with CSF (显示 CSF2 蛋白) complements C3 and C1q as well as to a disease severity measure.
This study reveled that C1QA having a central role in the bipolar disease and schizophrenia manifestation.
no significant association found to either rs15940 (C1QA) or rs172378 (C1QC (显示 C1QC 蛋白)) when analysed in just Parkinson disease cases , just controls or combined
Our findings showed that Brugia malayi Calreticulin (显示 CALR 蛋白) (BmCRT) is responsible for the prevention of classical complement pathway activation via its interaction with the first component C1q of the human host
interaction with calreticulin (显示 CALR 蛋白) controls the phagocyte inflammatory status
A newly characterized leech calreticulin (显示 CALR 蛋白) (HmCalR) has been shown to interact with C1q and participate to the HmC1q-dependent microglia accumulation.
findings show that C1q rather than FcgammaRs controls the Ab-mediated Ag uptake and its presentation by spleen APC (显示 APC 蛋白) subsets to T cells
Demonstrate local synthesis of complement proteins by both PDGFRbeta-positive pericytes and CD45 (显示 PTPRC 蛋白)-positive cells in kidney fibrosis.
Deleting C1qa gene significantly reduces synaptic pruning by Grn (显示 GRN 蛋白)(-/-) microglia and mitigates neurodegeneration, behavioral phenotypes, and premature mortality in Grn (显示 GRN 蛋白)(-/-) mice; results uncover a previously unrecognized role of progranulin (显示 GRN 蛋白) in suppressing aberrant microglia activation during aging.
developmental mechanisms of C1qa may be re-engaged during injury response
C1q is involved in the pristane-mediated enhanced inflammatory response to TLR7 (显示 TLR7 蛋白) stimulation.
Data (including data from studies in mutant mice) suggest exercise prevents age-related neurovascular decline, up-regulation of C1qa, and down-regulation of astrocytic Apoe (显示 APOE 蛋白); this preventive effect of exercise does not occur in Apoe (显示 APOE 蛋白)-deficient mice.
critical role in activation of beta-catenin (显示 CTNNB1 蛋白) signalling in hypertensive arterial remodelling
Data (including data on knockout mice) suggest, in absence of Trem2 (triggering receptor expressed on myeloid cells 2 (显示 TREM2 蛋白)), pulmonary macrophages selectively produce elevated levels of C1q resulting in enhanced phagocytosis during pneumococcal pneumonia.
C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 (显示 SOD1 蛋白) mice.
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q.
complement component 1, q subcomponent, alpha polypeptide
, complement C1q subcomponent subunit A
, complement component 1, q subcomponent, A chain
, complement component C1q, A chain
, complement C1qA