Complement System

补体系统是先天免疫系统的一部分,对提高机体免疫力、炎症、组织再生和其他生理进程起着非常重要的作用。补体激活不仅会引起病原体调理并被吞噬细胞清除,而且还会导致吞噬细胞和巨噬细胞的趋化现象。此外,补体系统还会形成终端抗体复合物(MAC),一个膜通道引起相应的病原体发生渗透性溶解。当补体无法适应时,可补给获得性免疫系统并且包含于B和T细胞反应调节。

补体激活会根据病原体的自然特性展开三种不同长度的补体激活途径:常规途径、凝集素途径和旁路途径。以上三种途径均会汇聚到常规终端途径并形成MAC。此外,C3a和C5a灭活因子会诱发生理学上的多血症,导致发生化学反应范围内的脱噬作用。补体系统包含的30多种蛋白质为可溶于血液中的可溶性蛋白,抑或是与蛋白相关的膜。多数现有的不活跃酵素原随后会相继被分裂并激活。所有三种途径中的中体均为C3(血液中含量最多的补给蛋白)。补体激活涵盖C3a、C3b和C5a的激活形成以及最终的MAC。

补体激活除了上述三种稳定途径之外,因子(例如胰舒血管素、胞浆素、凝血酶)以及XIIa还可单独激活补体系统,这样不需要C3蛋白。

Download pathway image as PDF

Classical Pathway

C1QA (Complement Component 1, Q Subcomponent, A Chain):

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first...

C1QB (Complement Component 1, Q Subcomponent, B Chain):

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first...

C1QC (Complement Component 1, Q Subcomponent, C Chain):

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first...

C1R (Complement Component 1, R Subcomponent):

C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
此分类里的别的抗原:
C1S (Complement Component 1, S Subcomponent): C1S 抗体 C1S ELISA试剂盒 C1S 蛋白
C4A - Complement C4: C4A 抗体 C4A ELISA试剂盒  
C4A (Complement Fragment 4a): C4A 抗体 C4A ELISA试剂盒 C4A 蛋白
C4 - Complement 4: C4 抗体 C4 ELISA试剂盒 C4 蛋白
C4B (Complement Component 4B): C4B 抗体 C4B ELISA试剂盒 C4B 蛋白

Lectin Pathway

MASP1 (Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor)):

This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This...   更多...
此分类里的别的抗原:
MBL2 (Mannose-Binding Lectin (Protein C) 2, Soluble): MBL2 抗体 MBL2 ELISA试剂盒 MBL2 蛋白
MASP2 (Mannan-Binding Lectin serine Peptidase 2): MASP2 抗体 MASP2 ELISA试剂盒 MASP2 蛋白
FCN1 (Ficolin (Collagen/fibrinogen Domain Containing) 1): FCN1 抗体 FCN1 ELISA试剂盒 FCN1 蛋白
FCN2 (Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin)): FCN2 抗体 FCN2 ELISA试剂盒 FCN2 蛋白
FCN3 (Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen)): FCN3 抗体 FCN3 ELISA试剂盒 FCN3 蛋白

Alternative Pathway

CFB - Complement Factor B

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a...

CFD - Adipsin

The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement...
此分类里的别的抗原:
C3 (Complement Component 3): C3 抗体 C3 ELISA试剂盒 C3 蛋白
C3B - Complement Component C3b: C3B 抗体    
CFH - Complement Factor H: CFH 抗体 CFH ELISA试剂盒 CFH 蛋白

Terminal Pathway

C5 - Complement Component 5

The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha...   更多...
此分类里的别的抗原:
C5a - C5A: C5a 抗体 C5a ELISA试剂盒 C5a 蛋白
C7 (Complement Component C7): C7 抗体 C7 ELISA试剂盒 C7 蛋白
C8A (Complement Component 8, alpha Polypeptide): C8A 抗体 C8A ELISA试剂盒 C8A 蛋白
C8B (Complement Component 8, beta Polypeptide): C8B 抗体 C8B ELISA试剂盒 C8B 蛋白
C8G (Complement Component 8, gamma Polypeptide): C8G 抗体 C8G ELISA试剂盒 C8G 蛋白
C9 (Complement Component C9): C9 抗体 C9 ELISA试剂盒 C9 蛋白

Regulators

CD55 (Complement Decay-Accelerating Factor):

This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating...

CD59 (CD59):

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction....
此分类里的别的抗原:
SERPING1 (Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1): SERPING1 抗体 SERPING1 ELISA试剂盒 SERPING1 蛋白
CFI - Complement Factor I: CFI 抗体 CFI ELISA试剂盒 CFI 蛋白
CR1 (Complement Component Receptor 1 (CD35)): CR1 抗体 CR1 ELISA试剂盒  
CFP (Complement Factor P): CFP 抗体 CFP ELISA试剂盒 CFP 蛋白
C4BPA (Complement Component 4 Binding Protein, alpha): C4BPA 抗体 C4BPA ELISA试剂盒 C4BPA 蛋白
C4BPB (Complement Component 4 Binding Protein, beta): C4BPB 抗体 C4BPB ELISA试剂盒 C4BPB 蛋白

Extrinsic Pathway

F2 - Prothrombin

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008].   更多...
此分类里的别的抗原:
PLG (Plasminogen): PLG 抗体 PLG ELISA试剂盒 PLG 蛋白
KLK1 - Kallikrein 1: KLK1 抗体 KLK1 ELISA试剂盒 KLK1 蛋白
KLK2 - Kallikrein 2: KLK2 抗体 KLK2 ELISA试剂盒 KLK2 蛋白
KLK3 - Kallikrein 3: KLK3 抗体   KLK3 蛋白
KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1): KLKB1 抗体 KLKB1 ELISA试剂盒 KLKB1 蛋白
PSA - Prostate Specific Antigen: PSA 抗体 PSA ELISA试剂盒 PSA 蛋白
KLK4 - Kallikrein 4: KLK4 抗体 KLK4 ELISA试剂盒 KLK4 蛋白
KLK5 - Kallikrein 5: KLK5 抗体 KLK5 ELISA试剂盒 KLK5 蛋白
KLK6 - Kallikrein 6: KLK6 抗体 KLK6 ELISA试剂盒 KLK6 蛋白
KLK7 - Kallikrein 7: KLK7 抗体 KLK7 ELISA试剂盒 KLK7 蛋白
KLK8 - Kallikrein 8: KLK8 抗体 KLK8 ELISA试剂盒 KLK8 蛋白
KLK9 - Kallikrein 9: KLK9 抗体 KLK9 ELISA试剂盒 KLK9 蛋白
KLK10 - Kallikrein 10: KLK10 抗体 KLK10 ELISA试剂盒 KLK10 蛋白
PRSS57 (Protease, Serine, 57): PRSS57 抗体 PRSS57 ELISA试剂盒 PRSS57 蛋白
KLK10 (Kallikrein Related-Peptidase 10): KLK10 抗体    
KLK11 - Kallikrein 11: KLK11 抗体 KLK11 ELISA试剂盒 KLK11 蛋白
KLK12 - Kallikrein 12: KLK12 抗体 KLK12 ELISA试剂盒 KLK12 蛋白
KLK13 - Kallikrein 13: KLK13 抗体 KLK13 ELISA试剂盒 KLK13 蛋白
KLK14 - Kallikrein 14: KLK14 抗体 KLK14 ELISA试剂盒 KLK14 蛋白
KLK15 - Kallikrein 15: KLK15 抗体 KLK15 ELISA试剂盒 KLK15 蛋白
F12 - Coagulation Factor XII (Hageman Factor): F12 抗体 F12 ELISA试剂盒 F12 蛋白