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Human Polyclonal TOPBP1 Primary Antibody for IP, PLA - ABIN151595
Liu, Luo, Lin, Lin: TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival. in Genes & development 2004
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Human Monoclonal TOPBP1 Primary Antibody for IF, WB - ABIN968691
Yamane, Katayama, Tsuruo: The BRCT regions of tumor suppressor BRCA1 and of XRCC1 show DNA end binding activity with a multimerizing feature. in Biochemical and biophysical research communications 2001
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Human Monoclonal TOPBP1 Primary Antibody for IF, WB - ABIN968690
Yamane, Kawabata, Tsuruo: A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator. in European journal of biochemistry / FEBS 1998
Show all 3 Pubmed References
The rs115160714 TopBP1 may be a genetic marker of etiology and progression in laryngeal cancer.
The innate immune regulator STAT-5 is shown to regulate transcription of the ATR binding factor TopBP1, and this is critical for the induction of the ATR pathway in human papillomavirus-infected keratinocytes.
TOPBP1 physically binds PLK1 (显示 PLK1 抗体) and promotes PLK1 (显示 PLK1 抗体) kinase-mediated phosphorylation of RAD51 (显示 RAD51 抗体) at serine 14, a modification required for RAD51 (显示 RAD51 抗体) recruitment to chromatin.
Functional analyses indicat that the expression TopBP1 and Claspin (显示 CLSPN 抗体) positively affects the survival of brain cancer cells after exposure to radiation.
TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.Crucial residues mediating TopBP1-MDC1 (显示 MDC1 抗体) interactions identified.
TopBP1 maintains genome integrity in mitosis by controlling chromatin recruitment of SLX4 (显示 BTBD12 抗体) and by facilitating unscheduled DNA synthesis.
Findings demonstrate that TopBP1 and ATR are able to inhibit the synthesis of rRNA and to activate nucleolar stress pathway.
TOPBP1 has a role in recruiting TOP2A (显示 TOP2A 抗体) to ultra-fine anaphase bridges to aid in their resolution
The results suggest that interactions between TopBP1 and E2 and between Brd4 (显示 BRD4 抗体) and E2 are required to correctly initiate human papillomavirus 16 DNA replication but are not required for continuing DNA replication.
Phosphorylation of BRIT1 protein coordinates TopBP1 protein recruitment and amplifies ATR signaling in cell DNA damage.
Consistent with prior reports, TopBP1 co-localized in discrete nuclear foci and was in complex with papillomavirus E2 protein (显示 UBE2B 抗体).
The deacetylated form of TopBP1 in SIRT1 (显示 SIRT1 抗体) mutant cells repressed replication origin firing, while the acetylated form of TopBP1 lost this function.
Studies identify the SIRT1 (显示 SIRT1 抗体)-TopBP1 axis as a key signaling mode in the regulation of the metabolic checkpoint and the DNA damage checkpoint.
TopBP1 is a crucial factor in V(D)J rearrangement during the development of B, T and iNKT cells.
Our data suggest that, unlike the yeast models, the TopBP1-AAD is the major activator of ATR, sustaining cell proliferation and embryonic development
TopBP1 is crucial for maintaining genome integrity in the early progenitors that drive neurogenesis.
Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin (显示 CLSPN 抗体) to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR (显示 ATR 抗体)) phosphorylation of checkpoint kinase 1 (Chk1 (显示 CHEK1 抗体)).
TopBP1 deficiency in untransformed mouse and human primary cells induces cellular senescence rather than apoptosis. These results indicate that TopBP1 is essential for cell proliferation and maintenance of chromosomal integrity.
ATR (显示 ATR 抗体) and TopBP1 monitor meiotic recombination and are required for activation of the meiotic recombination checkpoint
TopBP1 is a c-Abl-interacting protein and a repressor for c-Abl expression
Data show that TopBP1 and Nbs1 (显示 NLRP2 抗体) associate with the N-terminal region of Mdc1 (显示 MDC1 抗体) in egg extracts.
The critical ATR (显示 ATR 抗体) activator, TopBP1, senses DNA damage and stalled replication forks to initiate assembly of checkpoint signaling complexes.
TopBP1's C-terminal motif containing a putative nuclear localization signal was required for Importin beta (显示 KPNB1 抗体) interaction and that CT100 (显示 DPPA2 抗体) of Importin beta (显示 KPNB1 抗体) was required for TopBP1 interaction.
these findings indicate that WDR18 (显示 WDR18 抗体) is a bona fide checkpoint protein and that WDR18 (显示 WDR18 抗体) works together with TopBP1 to promote DNA damage checkpoint signaling.
MRN (MRE11 (显示 MRE11A 抗体)-RAD50 (显示 RAD50 抗体)-NBS1 (显示 NLRP2 抗体)) complex has role in ATR (显示 ATR 抗体) activation via TOPBP1 recruitment.
Cut5 plays an integral role in the recruitment and assembly of the Chk1 (显示 CHEK1 抗体) signaling cascade components following DNA damage
Data show that Rad17 (显示 RAD17 抗体) mediates the interaction of the Rad9 (显示 RAD9A 抗体)-Hus1 (显示 HUS1 抗体)-Rad1 (显示 ERCC4 抗体) (9-1-1) complex with the ATR (显示 ATR 抗体)-activating protein TopBP1 in Xenopus egg extracts.
Data show that recombinant TopBP1 induces a large increase in the kinase activity of both Xenopus and human ATR (显示 ATR 抗体)-ATRIP (显示 ATRIP 抗体).
GEMC1 (显示 GMNC 抗体) promotes initiation of chromosomal DNA replication in multicellular organisms by mediating TopBP1- and Cdk2 (显示 CDK2 抗体)-dependent recruitment of Cdc45 (显示 CDC45 抗体) onto replication origins.
Cut5 plays a crucial role in the initial amplification step of the ATR (显示 ATR 抗体)-Chk1 (显示 CHEK1 抗体) signaling pathway at the stalled replication fork.
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.
DNA topoisomerase 2-binding protein 1
, topoisomerase (DNA) II beta binding protein
, topoisomerase (DNA) II binding protein 1
, dna topoisomerase ii binding protein 1 (IC)
, DNA topoisomerase 2-binding protein 1-like
, DNA topoisomerase II-beta-binding protein 1
, DNA topoisomerase II-binding protein 1
, Cut5-related protein
, DNA topoisomerase 2-binding protein 1-A
, DNA topoisomerase 2-binding protein 1-B
, DNA topoisomerase II-binding protein 1-A
, DNA topoisomerase II-binding protein 1-B