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Results show that high Smad6 expression is correlated with increased risk of metastasis in ER negative breast cancer and that Smad6 determines BMP-regulated invasive behavior of breast cancer cells in a zebrafish xenograft model.
evaluated the role of inherited genetic variation in Langerhans cell histiocytosis susceptibility and identified a novel risk variant in SMAD6
This search revealed that rare mutations that disable one copy of a gene called SMAD6 in combination with a common DNA variant near another gene called BMP2 (显示 BMP2 ELISA试剂盒) account for about 7% of infants with midline forms of craniosynostosis.
Single Nucleotide Polymorphisms in SMAD6 gene is associated with brain metastasis in non-small-cell lung cancer
monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O and SMAD6 cooperated in the regulation of BMP7 (显示 BMP7 ELISA试剂盒)-induced adipogenesis
Smad6 indirectly maintains stemness by preventing spontaneous erythropoiesis in hematopoietic stem cells.
Loss of SMAD6 is associated with lung adenocarcinoma.
Congenital cardiovascular malformation is related to genetic variation in SMAD6
Haplotype analysis further revealed that two haplotype blocks within SMAD6 were significantly associated with decreased ovarian cancer risk, as compared to the most common haplotype.
results suggest that MyD88 (显示 MYD88 ELISA试剂盒) degradation driven by the Smad6-Smurf pathway is a novel mechanism for TGF-beta1 (显示 TGFB1 ELISA试剂盒)-mediated negative regulation of MyD88 (显示 MYD88 ELISA试剂盒)-dependent pro-inflammatory signalling
A complex form of acute rheumatic heart disease with tissue hardening is seen in the absence of either Smad-6 (or NKX2-5 (显示 NKX2-5 ELISA试剂盒)).
These results indicate that PRIP (显示 NCOA6 ELISA试剂盒) is implicated in BMP-induced osteoblast differentiation by the negative regulation of Smad (显示 SMAD1 ELISA试剂盒) phosphorylation, through the methylation of inhibitory Smad6
These findings suggest that TNF-alpha (显示 TNF ELISA试剂盒) induces valvular and vascular cell calcification, in part, by specifically reducing the expression of a BMP-2 (显示 BMP2 ELISA试剂盒) signaling inhibitor, Smad6.
The Smad6 is a novel target of Arkadia (显示 RNF111 ELISA试剂盒), and that Arkadia (显示 RNF111 ELISA试剂盒) positively regulates BMP signalling via degradation of Smad6, Smad7 (显示 SMAD7 ELISA试剂盒) and c-Ski (显示 SKI ELISA试剂盒)/SnoN (显示 SKIL ELISA试剂盒).
Smad6 inhibits non-canonical TGF-beta1 (显示 TGFB1 ELISA试剂盒) signaling by recruiting the deubiquitinase A20 (显示 TNFAIP3 ELISA试剂盒) to TRAF6 (显示 TRAF6 ELISA试剂盒).
Hepcidin (显示 HAMP ELISA试剂盒), Smad6 and Smad7 (显示 SMAD7 ELISA试剂盒) mRNA expression is coordinated in a way that it correlates with the activity of the Bmp/Smad (显示 SMAD1 ELISA试剂盒) signaling pathway.
Sema7A (显示 SEMA7A ELISA试剂盒) positively regulates the production of transforming growth factor (TGF)-beta1 (显示 TGFB1 ELISA试剂盒) and Smad6 to facilitate West Nile virus pathogenesis in mice.
Results indicate that peptidyl-prolyl isomerase (显示 PPI ELISA试剂盒) Pin1 (显示 PIN1 ELISA试剂盒) Associates with Smad3 (显示 SMAD3 ELISA试剂盒) and Smad6.
Data show that Runx1 (显示 RUNX1 ELISA试剂盒), in conjunction with Fli1 (显示 FLI1 ELISA试剂盒), Gata2 (显示 GATA2 ELISA试剂盒), and Scl (显示 TAL1 ELISA试剂盒), directly regulates the expression of Smad6 in the aorta-gonad-mesonephros region in the developing embryo, where hematopoietic stem cells originate.
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.
SMAD, mothers against DPP homolog 6
, MAD homolog 6
, Mothers against decapentaplegic, drosophila, homolog of, 6
, SMAD 6
, mothers against DPP homolog 6
, mothers against decapentaplegic homolog 6
, Smad 6
, mad homolog 7
, MAD, mothers against decapentaplegic homolog 6