anti-绵羊 p53 抗体 for Western Blotting

Recommended p53 Antibody (supplied by: Log in to see )

抗原
Tumor Protein P53 (TP53) 抗体
  • tp53
  • p53
  • TP53
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • TpMs
  • BCC7
  • LFS1
  • P53
  • TRP53
  • Trp53
  • Xp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • cellular tumor antigen p53
  • tumor protein p53
  • tumor supressor p53
  • p53 tumor suppressor
  • transformation related protein 53
  • transformation related protein 53, pseudogene
  • trichoplein, keratin filament binding
  • Wistar clone pR53P1 p53 pseudogene
  • CpipJ_CPIJ002758
  • TP53
  • tp53
  • P53
  • Trp53
  • Trp53-ps
  • TCHP
  • Tp53
  • p53-ps
抗原表位
N-Term
175
124
91
84
74
71
70
62
59
55
50
49
48
45
42
38
32
31
28
24
22
20
17
16
15
15
15
15
15
15
14
11
10
10
10
9
9
8
8
7
7
7
7
6
6
6
6
6
5
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
适用
牛, 豚鼠, 马, 人, 猪, 兔, 大鼠, 绵羊
2387
517
423
186
126
94
85
82
35
22
19
18
16
16
15
13
6
4
4
4
4
3
3
2
2
2
1
1
宿主

1364
1134
7
3
3
1
1
1
克隆类型
多克隆
标记
This p53 antibody is un-conjugated
81
78
65
54
46
45
31
31
26
25
25
25
25
25
25
24
24
24
22
20
19
18
14
14
14
14
14
12
7
5
5
5
5
5
5
5
5
4
3
2
2
2
应用范围
Western Blotting (WB)
1915
768
747
733
626
615
432
346
314
179
72
41
32
31
21
17
17
15
13
9
9
4
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
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产品编号 ABIN2777951
24,451.51 ¥
(含税, 含运费)
来自4A Biotech Co.,Ltd.(本地经销商)
获取报价
中国 北京 101111
No. 88 KeChuang 6th Street
Room 801-803
Beijing Economic Technological Development Area
4A Biotech Co.,Ltd.
Tel 400-7060-959
传真 +86 10 56315212-8813
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
2.9519167 ABIN2779317 ChIP IHC WB Rabbit N-Term Log in to see Polyclonal 1
2.9519167 ABIN2779979 WB Rabbit C-Term Log in to see Polyclonal 1
1 ABIN120054 EIA IHC (fro) IHC (p) IP WB Mouse IgG2a AA 20-25 Log in to see DO-1 3
1 ABIN320175 EIA IHC (fro) IHC (p) IP WB Mouse IgG2a AA 20-25 Log in to see DO-1 4
1 ABIN574482 IHC (p) WB Rabbit N-Term Log in to see Polyclonal
1 ABIN202409 WB Rabbit IgG AA 281-330 Log in to see Polyclonal
1 ABIN467883 WB Rabbit N-Term Log in to see Polyclonal

General

抗原 Tumor Protein P53 (TP53) 抗体
抗原表位 N-Term
(175), (124), (91), (84), (74), (71), (70), (62), (59), (55), (50), (49), (48), (45), (42), (38), (32), (31), (28), (24), (22), (20), (17), (16), (15), (15), (15), (15), (15), (15), (14), (11), (10), (10), (10), (9), (9), (8), (8), (7), (7), (7), (7), (6), (6), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
适用 牛, 豚鼠, 马, 人, 猪, 兔, 大鼠, 绵羊
(2387), (517), (423), (186), (126), (94), (85), (82), (35), (22), (19), (18), (16), (16), (15), (13), (6), (4), (4), (4), (4), (3), (3), (2), (2), (2), (1), (1)
宿主
(1364), (1134), (7), (3), (3), (1), (1), (1)
克隆类型
多克隆
标记 This p53 antibody is un-conjugated
(81), (78), (65), (54), (46), (45), (31), (31), (26), (25), (25), (25), (25), (25), (25), (24), (24), (24), (22), (20), (19), (18), (14), (14), (14), (14), (14), (12), (7), (5), (5), (5), (5), (5), (5), (5), (5), (4), (3), (2), (2), (2)
应用范围 Western Blotting (WB)
(1915), (768), (747), (733), (626), (615), (432), (346), (314), (179), (72), (41), (32), (31), (21), (17), (17), (15), (13), (9), (9), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 找到1个引用
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p53抗体详情

p53目标详情 使用细节 贮存及处理 ProductDetails: References for anti-p53 antibody (ABIN2777951) 图像
Blocking Peptide Blocking peptide for this product available: ABIN985387
序列 EEPQSDPSVE PPLSQETFSD LWKLLPENNV LSPLPSQAMD DLMLSPDDIE
预测反应 Cow: 100%, Guinea Pig: 86%, Horse: 90%, Human: 100%, Pig: 100%, Rabbit: 86%, Rat: 86%, Sheep: 100%
产品特性 This is a rabbit polyclonal antibody against TP53. It was validated on Western Blot using a cell lysate as a positive control.
纯化方法 Affinity Purified
免疫原 The immunogen is a synthetic peptide directed towards the N terminal region of human TP53

p53目标详情

p53抗体详情 使用细节 贮存及处理 ProductDetails: References for anti-p53 antibody (ABIN2777951) 图像 回页首
抗原
别名 TP53 (TP53 Antibody 摘要)
背景 TP53 acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
Alias Symbols: LFS1, TRP53, p53
Protein Size: 393
分子量 44 kDa
基因ID 7157
NCBI登录号 NM_000546, NP_000537
UniProt P04637
途径 p53 Pathway, MAPK Pathway, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy

使用细节

p53抗体详情 p53目标详情 贮存及处理 ProductDetails: References for anti-p53 antibody (ABIN2777951) 图像 回页首
应用备注 Optimal working dilutions should be determined experimentally by the investigator.
说明

Antigen size: 393 AA

限制 仅限研究用

贮存及处理

p53抗体详情 p53目标详情 使用细节 ProductDetails: References for anti-p53 antibody (ABIN2777951) 图像 回页首
状态 Liquid
浓度 Lot specific
缓冲液 Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

ProductDetails: References for anti-p53 antibody (ABIN2777951)

p53抗体详情 p53目标详情 使用细节 贮存及处理 图像 回页首
背景

Boehme, Kulikov, Blattner: "p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 22, pp. 7785-90, 2008

图像

p53抗体详情 p53目标详情 使用细节 贮存及处理 ProductDetails: References for anti-p53 antibody (ABIN2777951) 回页首
厂商提供的图像
Western Blotting (WB) image for anti-Tumor Protein P53 (TP53) (N-Term) antibody (ABIN2777951) WB Suggested Anti-TP53 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
Western Blotting (WB) image for anti-Tumor Protein P53 (TP53) (N-Term) antibody (ABIN2777951) Sample Type: 1. and 2. Human Cystic Fibrosis Bronchial Epithelial Cells (35ug)...