MEN1 (MEN1) ELISA试剂盒产品概述

Full name:
Multiple Endocrine Neoplasia 1 ELISA试剂盒 (MEN1)
在www.antibodies-online.cn可供1 Multiple Endocrine Neoplasia 1 (MEN1) ELISA试剂盒的1不同的供货商。 再加上,我们可以发MEN1 抗体 (125)MEN1 蛋白 (3)和数多这个蛋白质的别的产品。 总共133 MEN1产品已列进来了。
别名:
AW045611, meai, menin, scg2
list all ELISA KIts 基因 基因ID UniProt
MEN1 4221 O00255
小鼠 MEN1 MEN1 17283 O88559
大鼠 MEN1 MEN1 29417 Q9WVR8

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MEN1 (MEN1) ELISA试剂盒 by Reactivity

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Human Multiple Endocrine Neoplasia 1 (MEN1) interaction partners

  1. The results provide novel molecular insights into the tumor suppressor activity of menin, which is partly mediated by proteasomal degradation of beta-catenin (显示 CTNNB1 ELISA试剂盒) and inhibition of Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling.

  2. knockdown of RPA2 (显示 RPA2 ELISA试剂盒) promoted formation of the menin-p65 (显示 GORASP1 ELISA试剂盒) complex and repressed the expression of NF-kappaB (显示 NFKB1 ELISA试剂盒)-mediated genes. RPA2 (显示 RPA2 ELISA试剂盒) expression was induced via an E2F1 (显示 E2F1 ELISA试剂盒)-dependent mechanism in MCF7 and MDA-MB-231 cells treated with NF-kappaB (显示 NFKB1 ELISA试剂盒) activators, TNF-alpha (显示 TNF ELISA试剂盒) or lipopolysaccharide (LPS (显示 IRF6 ELISA试剂盒)).

  3. Loss of Menin is an early event in pancreatic neuroendocrine tumorigenesis and that ATRX (显示 ATRX ELISA试剂盒)/DAXX (显示 DAXX ELISA试剂盒) loss and alternative lengthening of telomeres are relatively late events.

  4. The lack of somatic CDKN1B (显示 CDKN1B ELISA试剂盒) mutations in our samples points to a rare involvement in parathyroid adenomas, despite the frequent loss of nuclear p27 (显示 PAK2 ELISA试剂盒) expression. MEN1 biallelic inactivation seems to be directly related to down-regulation of p27 (显示 PAK2 ELISA试剂盒) expression through the inhibition of CDKN1B (显示 CDKN1B ELISA试剂盒) gene transcription.

  5. This result shows a novel mechanism whereby menin, a RNA-binding protein, facilitates the processing of its specific miRNA by regulating the dynamics of the menin-miR-24 Gene Regulatory Network at the level of pri-miRNA processing.

  6. findings reveal a previously unappreciated cross-talk between two crucial tumor suppressor genes, MEN1 and DAXX (显示 DAXX ELISA试剂盒), thought to work by independent pathways

  7. Multiple endocrine neoplasia type 1-related primary hyperparathyroidism patients experienced more common kidney complications but less skeletal issues, and a milder biochemical manifestation compared with SHPT patients. MEN1 mutation detection rate was 79.4% and 9 of the identified mutations were novel.

  8. miR-24-dependent expression of menin may be important in the regulation of nonmalignant and cholangiocarcinoma proliferation.

  9. rs2959656, a nonsynonymous variant in MEN1, is associated with the development of clinically active pituitary adenoma.

  10. Study acts as a further supplement of the genetic features of neuroendocrine tumors. Somatic mutations of three potential tumor-related genes (HRAS, PAK1 and MEN1) might contribute to the tumorigenesis of thymic neuroendocrine tumors with EAS.

Mouse (Murine) Multiple Endocrine Neoplasia 1 (MEN1) interaction partners

  1. Menin and PRMT5 (显示 PRMT5 ELISA试剂盒) suppress GLP1R (显示 GLP1R ELISA试剂盒) transcript levels and PKA-mediated phosphorylation of FOXO1 (显示 FOXO1 ELISA试剂盒) and CREB (显示 CREB1 ELISA试剂盒).

  2. Inactivation of Kmt2a in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1.

  3. Data suggest that menin inhibits differentiation into terminal effectors and positively controls proliferation and survival of Ag-specific CD8 (显示 CD8A ELISA试剂盒)(+) T cells that are activated upon infection; study uncovered an important role for menin in the immune response of CD8 (显示 CD8A ELISA试剂盒)(+) T cells to infection

  4. Our data further confirms that deletion of Men1 alone does not favour carcinoid development, but rather cooperates with additional loci.

  5. Menin binds on the promoter of Inhbb (显示 INHBB ELISA试剂盒) gene where it favours the recruitment of Ezh2 (显示 EZH2 ELISA试剂盒) via an indirect mechanism involving Akt (显示 AKT1 ELISA试剂盒)-phosphorylation.

  6. Results indicate that fasted male Men1(+/-) mice, in the early stage of development of MEN1, display glucose metabolic disorders. These disorders are caused not by direct induction of insulin (显示 INS ELISA试剂盒) resistance, but via increased glucagon (显示 GCG ELISA试剂盒) secretion and the consequent stimulation of hepatic glucose production.

  7. The inactivation of menin in the thyroid gland of young mice does not seem to change the histological pattern, but it influences the proliferation of follicular cells. Further molecular studies especially in aged mice are needed to better understand the correlation between certain oncogenes and the inactive status of menin.

  8. Data show that progranulin is upregulated in neuroendocrine tumors (NETs) and islets of the multiple endocrine neoplasia 1 protein (MEN1) mouse as well as in the serum of patients with pancreatic NETs associated with glucagonoma syndrome.

  9. Although mice lacking Men1 developed insulinomas as expected, elimination of ARC (显示 NOL3 ELISA试剂盒) in this context did not significantly alter tumor load. Cellular rates of proliferation and death in these tumors were also not perturbed in the absence of ARC (显示 NOL3 ELISA试剂盒).

  10. The study characterized the binding position of Ezh2 and menin at all annotated genes in embryonic stem cells and B and T lymphocytes.

MEN1 抗原简介

Antigen Summary

This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with MEN1

  • multiple endocrine neoplasia I (MEN1) Elisa Kit
  • multiple endocrine neoplasia I (men1) Elisa Kit
  • multiple endocrine neoplasia 1 (Men1) Elisa Kit
  • multiple endocrine neoplasia I (Men1) Elisa Kit
  • AW045611 Elisa Kit
  • meai Elisa Kit
  • menin Elisa Kit
  • scg2 Elisa Kit

Protein level used designations for MEN1

menin , multiple endocrine neoplasia protein , multiple endocrine neoplasia 1 , multiple endocrine neoplasia I , menin-like

GENE ID SPECIES
4221 Homo sapiens
483758 Canis lupus familiaris
539431 Bos taurus
549115 Xenopus (Silurana) tropicalis
692344 Felis catus
743979 Pan troglodytes
100158320 Xenopus laevis
100411101 Callithrix jacchus
100441476 Pongo abelii
100472417 Ailuropoda melanoleuca
100523533 Sus scrofa
100538227 Danio rerio
17283 Mus musculus
29417 Rattus norvegicus
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