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anti-MBD2 (MBD2) 抗体产品概述

Full name:
anti-Methyl-CpG Binding Domain Protein 2 抗体 (MBD2)
在www.antibodies-online.cn可供123 Methyl-CpG Binding Domain Protein 2 (MBD2) 抗体的19不同的供货商。 再加上,我们可以发MBD2 蛋白 (3)MBD2 试剂盒 (1)和数多这个蛋白质的别的产品。 总共133 MBD2产品已列进来了。
别名:
DMTase, MBD2, MBD2a, NY-CO-41, wu:fa97f06, zgc:111862

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引用最多的anti-MBD2 抗体

  1. Human Polyclonal MBD2 Primary Antibody for EIA, WB - ABIN356599 : Zhu, Spitz, Zhang, Grossman, Frazier, Wu: Methyl-CpG-binding domain 2: a protective role in bladder carcinoma. in Cancer 2004 (PubMed)
    Show all 5 references for ABIN356599

  2. Human Polyclonal MBD2 Primary Antibody for IF, WB - ABIN1881531 : Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: A Large-scale genetic association study of esophageal adenocarcinoma risk. in Carcinogenesis 2010 (PubMed)
    Show all 3 references for ABIN1881531

  3. Human Polyclonal MBD2 Primary Antibody for IHC (p), IHC - ABIN188691 : Tan, Nakielny: Control of the DNA methylation system component MBD2 by protein arginine methylation. in Molecular and cellular biology 2006 (PubMed)
    Show all 2 references for ABIN188691

  4. Human Polyclonal MBD2 Primary Antibody for GS, WB - ABIN151224 : Ballestar, Paz, Valle, Wei, Fraga, Espada, Cigudosa, Huang, Esteller: Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer. in The EMBO journal 2003 (PubMed)
    Show all 2 references for ABIN151224

  5. Human Polyclonal MBD2 Primary Antibody for WB - ABIN387915 : Ghoshal, Majumder, Datta, Motiwala, Bai, Sharma, Frankel, Jacob: Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression. in The Journal of biological chemistry 2004 (PubMed)
    Show all 2 references for ABIN387915

  6. Human Polyclonal MBD2 Primary Antibody for WB - ABIN2779675 : Xing, Stewart, Gu, Lu, Spitz, Wu: Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer. in British journal of cancer 2008 (PubMed)
    Show all 2 references for ABIN2779675

  7. Human Polyclonal MBD2 Primary Antibody for IHC, ELISA - ABIN334432 : Auriol, Billard, Magdinier, Dante: Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus. in Nucleic acids research 2005 (PubMed)
    Show all 2 references for ABIN334432

  8. Dog (Canine) Polyclonal MBD2 Primary Antibody for EIA, IHC (p) - ABIN375214 : Spruijt, Bartels, Brinkman, Tjeertes, Poser, Stunnenberg, Vermeulen: CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex. in Molecular bioSystems 2010 (PubMed)

  9. Human Polyclonal MBD2 Primary Antibody for ICC, IF - ABIN257102 : Kim, Kwak, Weitz: Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor. in Molecular cell 2014 (PubMed)

  10. Chicken Polyclonal MBD2 Primary Antibody for WB - ABIN2778640 : Le Guezennec, Vermeulen, Brinkman, Hoeijmakers, Cohen, Lasonder, Stunnenberg: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. in Molecular and cellular biology 2006 (PubMed)

更多抗MBD2的相互作用对抗体

Human Methyl-CpG Binding Domain Protein 2 (MBD2) interaction partners

  1. MBD2 (显示 DPEP2 抗体) expression was elevated in HCC (显示 FAM126A 抗体) tissue, which suggesting MBD2 (显示 DPEP2 抗体) as a candidate prognostic marker of HCC (显示 FAM126A 抗体).

  2. downregulation of miR (显示 MLXIP 抗体)-221 inhibits cell migration and invasion at least partially through targeting MBD2 (显示 DPEP2 抗体) in the human OSCC cell line UM1.

  3. Specifically, methyl-CpG-binding domain protein 2 (MBD2) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD (显示 DPEP1 抗体) domain and MBD2 (显示 DPEP2 抗体) C-terminus.

  4. MBD2 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.

  5. The dynamics of MBD2 (显示 DPEP2 抗体) deposition across methylated DNA regions was associated with the oncogenic transformation of human mammary cells.

  6. Data suggest that MBD2 (显示 DPEP2 抗体) binds primarily at highly methylated regions, with a strong preference for CpG islands and highlights that MBD2 (显示 DPEP2 抗体) binding sites display increased methylation in primary breast cancer tissues as compared to normal mammary cells.

  7. Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 (显示 DPEP2 抗体) for methylated DNA.

  8. This study investigates the genetic association between methyl-CpG-binding domain (MBD (显示 DPEP1 抗体)) gene polymorphisms and schizophrenia.

  9. The methylated-DNA binding protein (显示 UBE2V1 抗体) MBD2 (显示 DPEP2 抗体) enhances NGFI-A (egr-1 (显示 EGR1 抗体))-mediated transcriptional activation of the glucocorticoid receptor (显示 NR3C1 抗体).

  10. These data point to a potential new approach in targeting the DNA methylation (显示 HELLS 抗体) machinery by combination of MBD2 (显示 DPEP2 抗体) and DNMT (显示 DNMT1 抗体) inhibitors.

Mouse (Murine) Methyl-CpG Binding Domain Protein 2 (MBD2) interaction partners

  1. Mbd2 has a key role regulating expression of a range of genes that are associated with optimal dendritic cell activation and function.

  2. MBD2 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.

  3. methyl-CpG-binding domain protein 2 (MBD2), an epigenetic regulator, controls autoimmunity and EAE through T-bet/Hlx (显示 HLX 抗体).

  4. Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 for methylated DNA.

  5. miR (显示 MLXIP 抗体)-290/371-Mbd2-Myc (显示 MYC 抗体) circuit regulates glycolytic metabolism to promote pluripotency.

  6. these findings suggest that CpG methylation and MBD2 are involved in altering Scn3a (显示 SCN3A 抗体) expression during postnatal development and seizure condition.

  7. Data suggest that methyl-CpG binding domain protein 2 (MBD2) gene knockout may lead to accumulation of more deposits on the Bruch's membrane (BM) and influence the pathogenesis of age-related macular degeneration (AMD (显示 AMD1 抗体)).

  8. In metastatic colorectal cancer cells, reduced levels of miR (显示 MLXIP 抗体)-221* and miR (显示 MLXIP 抗体)-224 increase levels of MBD2, thereby decreasing expression of the metastasis suppressor maspin (显示 SERPINB5 抗体).

  9. Mbd2 has a key role in promoting the Treg-specific demethylation region demethylation, Foxp3 (显示 FOXP3 抗体) expression, and Treg-suppressive function.

  10. Our results strengthen the possibility that MeCP2 (显示 MECP2 抗体) and MBD2 direct interactions could crosslink chromatin fibers and therefore give novel insight into the molecular mechanism of MBD (显示 DPEP1 抗体) mediated global heterochromatin architecture.

MBD2 抗原简介

Antigen Summary

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with MBD2

  • methyl-CpG binding domain protein 2 (MBD2) 抗体
  • methyl-CpG binding domain protein 2 (LOC100345590) 抗体
  • methyl-CpG binding domain protein 2 (Mbd2) 抗体
  • methyl-CpG binding domain protein 2 (mbd2) 抗体
  • DMTase 抗体
  • MBD2 抗体
  • MBD2a 抗体
  • NY-CO-41 抗体
  • wu:fa97f06 抗体
  • zgc:111862 抗体

Protein level used designations for MBD2

methyl-CpG binding domain protein 2 , demethylase , methyl-CpG-binding domain protein 2 , methyl-CpG-binding protein MBD2 , methyl-CpG binding protein MBD2

GENE ID SPECIES
455427 Pan troglodytes
100345590 Oryctolagus cuniculus
693801 Macaca mulatta
8932 Homo sapiens
17191 Mus musculus
337105 Danio rerio
399118 Xenopus laevis
497269 Gallus gallus
483975 Canis lupus familiaris
100337206 Bos taurus
680172 Rattus norvegicus
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