Lysyl Oxidase-Like 2 (LOXL2) ELISA试剂盒产品概述

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Lysyl Oxidase-Like 2 ELISA试剂盒 (LOXL2)
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1110004B06Rik, 4930526G11Rik, 9430067E15Rik, CG4402, Dmel\\CG4402, dmlox-2, Dmloxl-2, GB13360, LOR2, lox2-like, loxl-2, LOXL2, WS9-14

引用最多的Lysyl Oxidase-Like 2 ELISA试剂盒

  1. Human LOXL2 ELISA Kit for Sandwich ELISA - ABIN421170 : Coral, Madhavan, Pukhraj, Angayarkanni: High glucose induced differential expression of lysyl oxidase and its isoform in ARPE-19 cells. in Current eye research 2013 (PubMed)
    Show all 3 references for 421170

适于 Lysyl Oxidase-Like 2 相互作用对的更多 ELISA 试剂盒

Fruit Fly (Drosophila melanogaster) Lysyl Oxidase-Like 2 (LOXL2) interaction partners

  1. Dmloxl-1 and Dmloxl-2 are differentially expressed; active DmLOXL-1 influences gene expression and development

Human Lysyl Oxidase-Like 2 (LOXL2) interaction partners

  1. LOXL2 is a potential therapeutic target against tumor progression.

  2. Insulin (显示 INS ELISA试剂盒) resistance promotes lysyl oxidase like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.

  3. SMYD3 (显示 SMYD3 ELISA试剂盒) enhances tumorigenicity in esophageal squamous cell carcinoma by enhancing transcription of ezrin (显示 EZR ELISA试剂盒) and LOXL2, which are involved in proliferation, migration, and invasion.

  4. Data show that lysyl oxidase-like 2 (LOXL2) is a histone modifier enzyme that removes trimethylated lysine 4 (K4) in histone H3 (显示 HIST3H3 ELISA试剂盒) (H3K4me3) through an amino-oxidase reaction.

  5. LOXL2 was determined to promote proliferation of hepatocellular carcinoma (HCC (显示 FAM126A ELISA试剂盒)) and demonstrated to be highly expressed in HCC (显示 FAM126A ELISA试剂盒) adjacent non-tumor tissue samples compared with tumor tissue samples.

  6. LOXL2 messenger RNA levels were increased in intrahepatic cholangiocarcinoma. These results were confirmed at a protein level, with a significantly higher LOXL2 immunostaining tumoral stroma. Univariate analysis revealed that LOXL2 expression was correlated with a poor overall survival and disease-free survival.

  7. glomerular extracellular matrix. Altogether, we demonstrate that LOXL2 is a novel component of the molecular machinery that forms cross-linked collagen IV (显示 COL4 ELISA试剂盒) networks, which are essential for glomerular basement membrane stability and molecular ultrafiltration function.

  8. The expression levels of lysyl oxidase-like 2 (LOXL2) mRNA and protein were markedly suppressed in transfected prostate cancer cells with microRNAs miR (显示 MLXIP ELISA试剂盒)-26a, miR (显示 MLXIP ELISA试剂盒)-26b, miR (显示 MLXIP ELISA试剂盒)-29a, miR (显示 MLXIP ELISA试剂盒)-29b, miR (显示 MLXIP ELISA试剂盒)-29c and miR (显示 MLXIP ELISA试剂盒)-218.

  9. Overexpression of LOXL2 and SERPINH1 (显示 SERPINH1 ELISA试剂盒) was observed in clinical specimens of lung cancer and fibrotic lesions. Downregulation of miR (显示 MLXIP ELISA试剂盒)-29a caused overexpression of LOXL2 and SERPINH1 (显示 SERPINH1 ELISA试剂盒) in lung cancer and IPF, suggesting that these genes are involved in the pathogenesis of these two diseases.

  10. LOXL2 expression is significantly upregulated in human masticatory mucosa during wound healing

Mouse (Murine) Lysyl Oxidase-Like 2 (LOXL2) interaction partners

  1. Insulin (显示 INS ELISA试剂盒) resistance promotes lysyl oxidase like 2 (显示 LOXL3 ELISA试剂盒) induction and fibrosis accumulation in non-alcoholic fatty liver disease.

  2. glomerular extracellular matrix. Altogether, we demonstrate that LOXL2 (显示 LOXL3 ELISA试剂盒) is a novel component of the molecular machinery that forms cross-linked collagen IV (显示 COL4 ELISA试剂盒) networks, which are essential for glomerular basement membrane stability and molecular ultrafiltration function.

  3. LOX (显示 LOX ELISA试剂盒) and LOXL2 (显示 LOXL3 ELISA试剂盒) may play an important role in the pathogenesis of AMD (显示 AMD1 ELISA试剂盒). Targeting LOXL2 (显示 LOXL3 ELISA试剂盒) could have a broader efficacy than targeting LOX (显示 LOX ELISA试剂盒), by reducing angiogenesis and inflammation, as well as fibrosis.

  4. Loss and gain of function analyses combined with in vivo studies in syngeneic breast cancer models demonstrate the participation of LOXL2 (显示 LOXL3 ELISA试剂盒) and E47 (显示 TCF3 ELISA试剂盒) in tumor growth and their requirement for lung metastasis.

  5. Findings reveal new insight into the mechanisms of fibroblast activation, a novel function of LOXL2 (显示 LOXL3 ELISA试剂盒), and further highlight the importance of generating LOXL2 (显示 LOXL3 ELISA试剂盒)-targeted therapies for the prevention of tumor progression and metastasis.

  6. The Snail1 (显示 SNAI1 ELISA试剂盒) transcription factor represses mouse pericentromeric transcription, acting through the H3K4 deaminase LOXL2 (显示 LOXL3 ELISA试剂盒).

  7. The enzymatic activity of lysyl oxidas-like-2 (LOXL2 (显示 LOXL3 ELISA试剂盒)) is not required for LOXL2 (显示 LOXL3 ELISA试剂盒)-induced inhibition of keratinocyte differentiation.

  8. This study provides the first evidence for the role of LOXL2 (显示 LOXL3 ELISA试剂盒) in regulating angiogenesis through collagen IV (显示 COL4 ELISA试剂盒) scaffolding.

  9. LOXL2 (显示 LOXL3 ELISA试剂盒) promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation

  10. The efficacy and safety of LOXL2 (显示 LOXL3 ELISA试剂盒)-specific monoclonal antibody represents a new therapeutic approach with broad applicability in oncologic and fibrotic diseases.

Lysyl Oxidase-Like 2 (LOXL2) 抗原简介

Antigen Summary

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

Alternative names and synonyms associated with Lysyl Oxidase-Like 2 (LOXL2)

  • lysyl oxidase-like 2 (lox2) Elisa Kit
  • lysyl oxidase-like 2 (LOXL2) Elisa Kit
  • lysyl oxidase-like 2 (loxl2) Elisa Kit
  • lysyl oxidase-like 2 (Loxl2) Elisa Kit
  • 1110004B06Rik Elisa Kit
  • 4930526G11Rik Elisa Kit
  • 9430067E15Rik Elisa Kit
  • CG4402 Elisa Kit
  • Dmel\\CG4402 Elisa Kit
  • dmlox-2 Elisa Kit
  • Dmloxl-2 Elisa Kit
  • GB13360 Elisa Kit
  • LOR2 Elisa Kit
  • lox2-like Elisa Kit
  • loxl-2 Elisa Kit
  • LOXL2 Elisa Kit
  • WS9-14 Elisa Kit

Protein level used designations for LOXL2

CG4402-PA , lox2-PA , lysyl oxidase-like 2 , Lysyl oxidase-like protein 2 , lysyl oxidase homolog 2 , lysyl oxidase homolog 2-like , lysyl oxidase related 2 , lysyl oxidase-like protein 2 , lysyl oxidase-related protein 2 , lysyl oxidase-related protein WS9-14 , Lysyl oxidase homolog 2

GENE ID SPECIES
37485 Drosophila melanogaster
408544 Apis mellifera
585092 Strongylocentrotus purpuratus
100158339 Xenopus laevis
100216062 Xenopus (Silurana) tropicalis
100413360 Callithrix jacchus
464053 Pan troglodytes
710151 Macaca mulatta
100543026 Meleagris gallopavo
4017 Homo sapiens
419533 Gallus gallus
486118 Canis lupus familiaris
532684 Bos taurus
94352 Mus musculus
290350 Rattus norvegicus
100171427 Pongo abelii
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