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抗Human BRD4 抗体:
抗Mouse (Murine) BRD4 抗体:
抗Rat (Rattus) BRD4 抗体:
Human Polyclonal BRD4 Primary Antibody for ICC, IF - ABIN438710
Rahman, Sowa, Ottinger, Smith, Shi, Harper, Howley: The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. in Molecular and cellular biology 2011
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Human Polyclonal BRD4 Primary Antibody for ChIP, WB - ABIN2668492
Flajollet, Rachez, Ploton, Schulz, Gallais, Métivier, Pawlak, Leray, Issulahi, Héliot, Staels, Salbert, Lefebvre: The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors. in PLoS ONE 2013
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Human Polyclonal BRD4 Primary Antibody for ICC, IF - ABIN4285227
Zuber, Shi, Wang, Rappaport, Herrmann, Sison, Magoon, Qi, Blatt, Wunderlich, Taylor, Johns, Chicas, Mulloy, Kogan, Brown, Valent, Bradner, Lowe, Vakoc: RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. in Nature 2011
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Brd4 associates with mitotic chromosomes throughout early zebrafish embryogenesis
BRD4 and MYC (显示 MYC 抗体) are essential for the expression of a subgroup of genes induced by class-I HDAC (显示 HDAC3 抗体) inhibitors.
Data show that BRD4 controls RUNX2 (显示 RUNX2 抗体) by binding to the enhancers (ENHs) and each RUNX2 (显示 RUNX2 抗体) ENH (显示 PDLIM5 抗体) is potentially controlled by a distinct set of TFs and c-JUN (显示 JUN 抗体) as the principal pivot of this regulatory platform.
any of the molecules or processes in the network could be targeted to curb the oncogenic effects of c-Myc (显示 MYC 抗体), just as BRD4 can be targeted. And since the targeting of metabolic enzymes has proved effective in mouse tumor models, it might be possible to develop new therapies based on the fact that c-Myc (显示 MYC 抗体) has a role in controlling cellular metabolism
Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-beta (显示 TGFB1 抗体)-mediated Nox4 (显示 NOX4 抗体) expression.
The response of the kinome to targeted BETi treatment in a panel of BRD4-dependent ovarian carcinoma (OC) cell lines.
A miR (显示 MLXIP 抗体)-9 mimic represses stimulus-dependent targeting of BRD4.
BRD4 and CDK9 (显示 CDK9 抗体) have independent, coordinated roles in promoting the myofibroblast transition
Long-term treatment with bromodomain-containing protein 4 (BRD4) inhibitors caused telomere shortening in both mouse and human cells, suggesting BRD4 plays a role in telomere maintenance in vivo.
The short isoform of BRD4 cooperates with SWI (显示 SMARCA1 抗体)/SNF (显示 SNRPA 抗体) nucleosome remodelers to repress HIV transcription during latency, a phenotype reversed by BET inhibitor treatment.
results indicated that in MPNST samples BRD4 mRNA levels were not upregulated and that MPNST cell lines were relatively insensitive to the bromodomain inhibitor JQ1.
Using compound selectivity engineering and CRISPR/Cas9 genome editing, distinct functions for Erk5 (显示 MAPK7 抗体) and Brd4 in pluripotency regulation of mouse embryonic stem cells have been revealed.
Fmr1 (显示 FMR1 抗体) knockout (KO) mice show widespread changes in histone marks as well as transcriptional misregulation resulting in increased expression of many critical synaptic genes. Data suggest that one chromatin target of FMRP (显示 FMR1 抗体), the reader protein Brd4, appears to be significantly involved in this transcriptional disruption.
The functional domains of mouse BRD4 and its role in transcription are described. Review.
Brd2 (显示 BRD2 抗体) and Brd4 genetic transcription required for Th17 cell development and adaptive immunity.
These data provide a detailed mechanism for how activated NF-kappaB (显示 NFKB1 抗体) and BRD4 control epithelial-mesenchymal transition initiation and transcriptional elongation in model airway epithelial cells in vitro and in a murine pulmonary fibrosis model in vivo.
DOT1L (显示 DOT1L 抗体), via dimethylated histone H3 (显示 HIST3H3 抗体) K79, facilitates histone H4 (显示 HIST1H4H 抗体) acetylation, which in turn regulates the binding of BRD4 to chromatin in acute lymphoblastic leukemia.
Acute induction of genes related to lipid accumulation in the livers of mice force-fed with fructose is associated with the induction of histone acetylation and BRD4 binding around these genes
Both mouse and human BRD4 have intrinsic histone acetyltransferase (显示 HAT 抗体) activity.
the interaction between BRD4 and Mediator has functional importance for gene-specific transcriptional activation and for acute myeloid leukemia (显示 BCL11A 抗体) maintenance.
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15\;19)(q13\;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.
Bromodomain-containing protein 4B
, bromodomain-containing protein 4B
, bromodomain containing 4
, bromodomain-containing protein 4
, bromodomain 4
, bromodomain-containing protein 4-like
, bromodomain containing protein 4
, bromodomain-containing 4
, chromosome-associated protein
, bromodomain-containing 5
, fsh-like protein
, mitotic chromosome-associated protein