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The bromodomain and extraterminal domain (BET) family consists of BRDT (显示 BRDT ELISA试剂盒), BRD2, BRD3 (显示 BRD3 ELISA试剂盒), and BRD4 (显示 BRD4 ELISA试剂盒), each containing 2 bromodomains located N-terminal to extraterminal domain, which is located near C-terminus. Data suggest that 10 distinct acylations participate in binding of BET family proteins to histone 4 (oligopeptide fragments used here); C-terminal bromodomains do not cooperatively bind multiple acylation sites.
The identification of RNF43 (显示 RNF43 ELISA试剂盒) mutations in a distinct subset of intraductal papillary neoplasm of the bile ducts revealed a new molecular role in the pathogenesis of this disease
LRP1B (显示 LRP1B ELISA试剂盒), BRD2 and CACNA1D (显示 CACNA1D ELISA试剂盒) are new candidate genes in fetal metabolic programming of newborns exposed to maternal hyperglycemia.
This study implicates BET Brds as important regulators of IkappaB kinase (显示 CHUK ELISA试剂盒)/NF-kappaB (显示 NFKB1 ELISA试剂盒)-mediated synovial inflammation of RA and identifies BET proteins as novel therapeutic targets in inflammatory arthritis.
An unexpected role for the bromodomain and extraterminal domain (BET) proteins BRD2 and BRD4 (显示 BRD4 ELISA试剂盒) in maintaining oncogenic IKK (显示 CHUK ELISA试剂盒) activity in activated B-cell-like diffuse large B-cell lymphoma.
BET proteins, particularly Brd2 and Brd4 (显示 BRD4 ELISA试剂盒), may play a key role in the regulation of Nrf2 (显示 GABPA ELISA试剂盒)-dependent antioxidant gene transcription and are hence an important target for augmenting antioxidant responses in oxidative stress-mediated diseases.
The C-terminal domain of Brd2 is important for chromatin interaction and regulation of transcription and alternative splicing.
A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins.
The SNP alleles in BRD2, Cx-36 (显示 GJD2 ELISA试剂盒), and ME2 (显示 CELSR1 ELISA试剂盒) and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myoclonic epilepsy'
BRD2, BRD3 (显示 BRD3 ELISA试剂盒), and BRD4 (显示 BRD4 ELISA试剂盒) interact with gammaretroviral INs (显示 INS ELISA试剂盒) and serve as cofactors for murine leukemia virus integration.
these results provided evidence for a novel role of Brd2 in chronic inflammation and insulin (显示 INS ELISA试剂盒) resistance.
BRD2 acts to augment the boundary function of CTCF (显示 CTCF ELISA试剂盒) both by limiting the spread or range of enhancer activity and by physically preventing the formation of cross-boundary contacts genome-wide.
Brd2 and Brd4 (显示 BRD4 ELISA试剂盒) genetic transcription required for Th17 cell development and adaptive immunity.
This study reveals an antagonistic relationship between H2A.Z (显示 H2AFZ ELISA试剂盒).1ub and BRD2 to regulate the transcriptional balance at bivalent genes to enable proper execution of developmental programs.
BRD2 is involved in the modulation of neuroinflammatory responses through PAI-1 (显示 SERPINE1 ELISA试剂盒) and via the regulation of epigenetic reader BET protein
DNA demethylation of the Brd2 promoter region induced Brd2 expression during differentiation of 3T3-L1 cells into adipocytes.
Brd2 inhibits adipogenesis via the ERK1/2 (显示 MAPK1/3 ELISA试剂盒) signaling pathway in 3T3-L1 adipocytes.
We conclude that Brd2 plays a critical, independent role in regulation of mitogenic response genes
Data show that infection of macrophages with Listeria monocytogenes caused binding of the BET proteins Brd2, Brd3, and, most prominently, Brd4 to the Nos2 promoter.
brd2a on chromosome 19 exhibits both maternal and zygotic contributions to early development and patterning, analogous to the brd2 ortholog in Drosophila.
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.
, bromodomain-containing 2
, bromodomain-containing protein 2
, female sterile homeotic-related gene 1
, really interesting new gene 3 protein
, collagen type XI alpha 2
, glutamate-cysteine ligase catalytic subunit
, ring finger protein 3