PLAU 蛋白 (PLAU)产品概述

Full name:
Plasminogen Activator, Urokinase 蛋白 (PLAU)
在www.antibodies-online.cn可供60 Plasminogen Activator, Urokinase (PLAU) 蛋白的17不同的供货商。 再加上,我们可以发PLAU 抗体 (347)PLAU 试剂盒 (108)和数多这个蛋白质的别的产品。 总共526 PLAU产品已列进来了。
别名:
ATF, BDPLT5, PLAU, QPD, u-PA, uPA, UPAM, URK
列出全部蛋白 基因 基因ID UniProt
PLAU 5328 P00749
PLAU 18792 P06869
PLAU 25619  

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引用最多的PLAU 蛋白

  1. Human PLAU Protein expressed in Human - ABIN491612 : Reichel, Uhl, Lerchenberger, Puhr-Westerheide, Rehberg, Liebl, Khandoga, Schmalix, Zahler, Deindl, Lorenzl, Declerck, Kanse, Krombach: Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via mac-1, but independently of urokinase-type plasminogen activator receptor. in Circulation 2011 (PubMed)
    Show all 6 references for 491612

  2. Human PLAU Protein expressed in Human Cells - ABIN2003433 : Nagai, Hiramatsu, Kanéda, Hayasuke, Arimura, Nishida, Suyama: Molecular cloning of cDNA coding for human preprourokinase. in Gene 1985 (PubMed)
    Show all 4 references for 2003433

  3. Human PLAU Protein expressed in Human - ABIN491028 : Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011 (PubMed)

  4. Mouse (Murine) PLAU Protein expressed in Insect Cells - ABIN2544534 : Bryer, Fantuzzi, Van Rooijen, Koh: Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regeneration. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)

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Human Plasminogen Activator, Urokinase (PLAU) interaction partners

  1. suggest that the low endogenous levels of uPA (显示 PRAP1 蛋白) in blood are actively regulated, and that the regulatory mechanisms are disrupted in QPD in a megakaryocyte-specific manner

  2. an intricate link between caveolin-1 (显示 CAV1 蛋白) and Src kinase (显示 CSK 蛋白)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C (显示 SFTPC 蛋白) expression through p53 (显示 TP53 蛋白) and uPA (显示 PRAP1 蛋白) system-mediated cross-talk, is reported.

  3. results show that the uPA (显示 PRAP1 蛋白)/uPAR (显示 PLAUR 蛋白)/LRP1 (显示 LRP1 蛋白) system is a potential target for the development of therapeutic strategies to promote axonal recovery following a CNS injury

  4. The present research concluded that aspirin suppressed prostate cancer cell invasion by reducing MMP-9 (显示 MMP9 蛋白) activity and uPA (显示 PRAP1 蛋白) expression through decreasing of IKK-beta (显示 IKBKB 蛋白)-mediated NF-kappaB (显示 NFKB1 蛋白) activation, indicating that the ability of aspirin to inhibit cell invasion might be useful in the chemoprevention of metastatic prostate cancer.

  5. These studies identify uPA (显示 PRAP1 蛋白)-dependent de-repression of vegfr1 (显示 FLT1 蛋白) and vegfr2 (显示 KDR 蛋白) gene transcription through binding to HHEX/PRH (显示 HHEX 蛋白) as a novel mechanism by which uPA (显示 PRAP1 蛋白) mediates the pro-angiogenic effects of VEGF (显示 VEGFA 蛋白) and identifies a potential new target for control of pathologic angiogenesis.

  6. We concluded that overexpression of MMP-3 (显示 MMP3 蛋白) and uPA (显示 PRAP1 蛋白), altogether with diminished expression of PAI-1 (显示 SERPINE1 蛋白) from metastatic tumors, might be a crucial step towards metastasis in ductal breast cancer.

  7. The up-regulation of uPA (显示 PRAP1 蛋白) mRNAs was correlated with high-risk clinicopathological features, including extrathyroid invasion, loss of cellular polarity/cohesiveness, and the BRAF (显示 BRAF 蛋白)(V600E) mutation.

  8. In contrast to platelet-derived growth factor, all urokinase isoforms induced secretion of MMP-9 (显示 MMP9 蛋白) by mesenchymal stromal cells.

  9. Transplantation of uPA (显示 PRAP1 蛋白) gene modified mesenchymal stem cells suppressed liver fibrosis and ameliorated liver function and may be a new approach to treating liver fibrosis

  10. ApaL1 and Taq1 single nucleotide polymorphisms of the urokinase and VDR (显示 CYP27B1 蛋白) genes are associated with recurrent urolithiasis in a Caucasian population.

Mouse (Murine) Plasminogen Activator, Urokinase (PLAU) interaction partners

  1. an intricate link between caveolin-1 (显示 CAV1 蛋白) and Src kinase (显示 CSK 蛋白)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C (显示 SFTPC 蛋白) expression through p53 (显示 TP53 蛋白) and uPA system-mediated cross-talk, is reported.

  2. These studies identify uPA-dependent de-repression of vegfr1 (显示 FLT1 蛋白) and vegfr2 (显示 KDR 蛋白) gene transcription through binding to HHEX/PRH (显示 HHEX 蛋白) as a novel mechanism by which uPA mediates the pro-angiogenic effects of VEGF (显示 VEGFA 蛋白) and identifies a potential new target for control of pathologic angiogenesis.

  3. Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.

  4. GM-CSF (显示 CSF2 蛋白) and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.

  5. Plau deficiency does not worsen controlled cortical impact-induced brain pathology or epileptogenesis caused by TBI (显示 TBPL1 PLURAL_@42429@).

  6. we have firstly shown a fundamental mechanism of urokinase system(uPa and uPAR (显示 PLAUR 蛋白))-dependent regulation of the trajectory of growth and branching of blood vessels in early embryogenesis and in adults during the repair/regeneration of tissues.

  7. Pharmacological inhibition of either uPA or selected MMPs decreased atherosclerosis in transgenic uPA mice.

  8. Study shows that the competitive expression or activity of tPA (显示 PLAT 蛋白) and/or PAI-1 (显示 SERPINE1 蛋白), rather than an altered uPA expression, determines the plasmin (显示 PLG 蛋白)-mediated Abeta (显示 APP 蛋白) proteolysis in brains affected by Alzheimer's disease

  9. Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage uPA.

  10. beta-elemene downregulates expression of uPA, uPAR (显示 PLAUR 蛋白), MMP-2 (显示 MMP2 蛋白), and MMP-9 (显示 MMP9 蛋白) in a murine intraocular melanoma model

Rabbit Plasminogen Activator, Urokinase (PLAU) interaction partners

  1. uPA-mediated arterial constriction is a vasomotor process that is mediated by uPA catalytic activity, not by the NH(2)-terminal domains.

Cow (Bovine) Plasminogen Activator, Urokinase (PLAU) interaction partners

  1. Data show that urokinase-type plasminogen activator (uPA) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA receptor (uPAR (显示 PLAUR 蛋白)) and plasminogen activator inhibitor-1 (PAI-1 (显示 SERPINE1 蛋白)) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.

  2. uPA/uPAR (显示 PLAUR 蛋白) binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.

  3. These data indicated that E. coli LPS (显示 IRF6 蛋白) led to an increase in u-PA activity and RNA expression of u-PA and u-PAR (显示 PLAUR 蛋白) in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.

  4. The plasminogen/plasminogen (显示 PLG 蛋白) activator/plasmin (显示 PLG 蛋白) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

  5. stage-dependent regulation of granulosa cell PA and SerpinE2 (显示 SERPINE2 蛋白) production, consistent with a role in extracellular matrix remodeling during follicle growth.

Pig (Porcine) Plasminogen Activator, Urokinase (PLAU) interaction partners

  1. The plasminogen/plasminogen (显示 PLG 蛋白) activator/plasmin (显示 PLG 蛋白) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

蛋白简介PLAU

蛋白简介

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PLAU

  • plasminogen activator, urokinase (PLAU)
  • urokinase-type plasminogen activator (CpipJ_CPIJ002131)
  • urokinase-type plasminogen activator (CpipJ_CPIJ006543)
  • urokinase-type plasminogen activator (CpipJ_CPIJ013396)
  • urokinase-type plasminogen activator (CpipJ_CPIJ013623)
  • plasminogen activator, urokinase (Plau)
  • ATF 蛋白
  • BDPLT5 蛋白
  • PLAU 蛋白
  • QPD 蛋白
  • u-PA 蛋白
  • uPA 蛋白
  • UPAM 蛋白
  • URK 蛋白

Protein level used designations for PLAU

urokinase-type plasminogen activator , U-plasminogen activator , uPA , plasminogen activator, urokinase , plasminogen activator, urinary , Urinary plasminogen activator, urokinase , urokinase plasminogen activator preproprotein

GENE ID SPECIES
403426 Canis lupus familiaris
100171578 Pongo abelii
100302501 Ovis aries
6032874 Culex quinquefasciatus
6038214 Culex quinquefasciatus
6046380 Culex quinquefasciatus
6047199 Culex quinquefasciatus
5328 Homo sapiens
18792 Mus musculus
25619 Rattus norvegicus
100008633 Oryctolagus cuniculus
281408 Bos taurus
396424 Gallus gallus
396985 Sus scrofa
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