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PDE4B 抗体

(phosphodiesterase 4B, cAMP-Specific (PDE4B))
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
PDE4B 抗体  (AA 500-736) PDE4B 抗体  (AA 500-736) PDE4B 抗体 (AA 500-736) (ABIN7442141)

PDE4B 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

PDE4B 抗体  (C-Term) PDE4B 抗体  (C-Term) PDE4B 抗体 (C-Term) (ABIN185574)

Verified PDE4B 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

PDE4B 抗体  (AA 27-215) PDE4B 抗体  (AA 27-215) PDE4B 抗体 (AA 27-215) (ABIN7146632)

PDE4B 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

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PDE4B 抗体 by 适用

Find PDE4B 抗体 for a variety of species such as anti-Human PDE4B, anti-Rat PDE4B, anti-Mouse PDE4B. The species listed below are among those available. Click on a link to go to the corresponding products.

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PDE4B 抗体 by 克隆形成能力

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PDE4B 抗体 by 克隆

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Find PDE4B 抗体 with a specific conjugate such as FITC, Biotin, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular PDE4B 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7442141
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN185574
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7146632
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN2855498
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN6145350
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF, ICC
Validations
  • (1)
Cat. No. ABIN2855496
Quantity 100 μL
Datasheet Datasheet
Reactivity Bat, Chicken, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN6746441
Quantity 100 μL
Datasheet Datasheet
Reactivity Bat, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Pig, Rat
Application WB, IHC, IHC (p)
Validations
  • (1)
Cat. No. ABIN6755460
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC, FACS, IF, IHC (p)
Validations
  • (1)
Cat. No. ABIN2582958
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB
Validations
  • (2)
Cat. No. ABIN4904711
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, FACS
Validations
  • (2)
Cat. No. ABIN655630
Quantity 400 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application WB
Validations
  • (1)
  • (1)
Cat. No. ABIN2786603
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, FACS, EIA
Validations
  • (2)
Cat. No. ABIN954065
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application
Validations
Cat. No. ABIN7146634
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7146633
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our PDE4B 抗体

Massimi, Cardarelli, Galli, Giardi, Ragusa, Panera, Cinque, Cifone, Biagioni, Giorgi: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." in: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).

Johanns, Lai, Hsu, Jacobs, Vertommen, Van Sande, Dumont, Woods, Carling, Hue, Viollet, Foretz, Rider: "AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B." in: Nature communications, Vol. 7, pp. 10856, (2016) (PubMed).

Cedervall, Aulabaugh, Geoghegan, McLellan, Pandit: "Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 12, pp. E1414-22, (2015) (PubMed).

Nagy, Ross, Rodriguez, Balint, Szeles, Nagy, Kirken: "Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells." in: PLoS ONE, Vol. 8, Issue 2, pp. e57326, (2013) (PubMed).

Vang, Housley, Dong, Basole, Ben-Sasson, Kream, Epstein, Clark, Brocke: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." in: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).

Fatemi, King, Reutiman, Folsom, Laurence, Lee, Fan, Paciga, Conti, Menniti: "PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia." in: Schizophrenia research, Vol. 101, Issue 1-3, pp. 36-49, (2008) (PubMed).

Millar, Pickard, Mackie, James, Christie, Buchanan, Malloy, Chubb, Huston, Baillie, Thomson, Hill, Brandon, Rain, Camargo, Whiting, Houslay, Blackwood, Muir, Porteous: "DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling." in: Science (New York, N.Y.), Vol. 310, Issue 5751, pp. 1187-91, (2005) (PubMed).

Barette, Jariel-Encontre, Piechaczyk, Piette: "Human cyclin C protein is stabilized by its associated kinase cdk8, independently of its catalytic activity." in: Oncogene, Vol. 20, Issue 5, pp. 551-62, (2001) (PubMed).

Johnson, Walker: "Cyclins and cell cycle checkpoints." in: Annual review of pharmacology and toxicology, Vol. 39, pp. 295-312, (1999) (PubMed).

Aliases for PDE4B 抗体

phosphodiesterase 4B (pde4b) 抗体
phosphodiesterase 4B (PDE4B) 抗体
phosphodiesterase 4B, cAMP specific (Pde4b) 抗体
phosphodiesterase 4B (Pde4b) 抗体
phosphodiesterase 4B S homeolog (pde4b.S) 抗体
dpde4 抗体
Dpde4 抗体
DPDE4 抗体
dunce 抗体
PDE4/IVb 抗体
Pde4B1 抗体
Pde4B2 抗体
Pde4B3 抗体
Pde4B4 抗体
pde4b5 抗体
PDE4B5 抗体
pdeivb 抗体
PDEIVB 抗体
R74983 抗体
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