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IL12B 蛋白

(Interleukin 12 beta (IL12B))
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].
IL12B Protein (AA 23-328) (His tag) IL12B Protein (AA 23-328) (His tag) IL12B Protein (AA 23-328) (His tag) (ABIN7275396)

IL12B 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE

IL12B Protein (AA 23-328) (His tag) IL12B Protein (AA 23-328) (His tag) IL12B Protein (AA 23-328) (His tag) (ABIN7275395)

IL12B 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

IL12B Protein (AA 23-328) (His tag) IL12B Protein (AA 23-328) (His tag) IL12B Protein (AA 23-328) (His tag) (ABIN1019696)

IL12B 宿主: 人 宿主: Tobacco (Nicotiana benthamiana) Recombinant > 97 % by SDS polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue. WB, Imm

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IL12B 蛋白 by Source

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Popular IL12B 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7275396
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275395
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana benthamiana)
Validations
  • (2)
Cat. No. ABIN1019696
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5569897
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Human Cells
Validations
  • (1)
Cat. No. ABIN7320572
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1307678
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN5569896
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3134079
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN2181332
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN2181334
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (3)
  • (1)
Cat. No. ABIN1047232
Quantity 100 μg
Datasheet Datasheet
Reactivity Sheep
Source Yeast
Validations
  • (2)
Cat. No. ABIN7479103
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
Cat. No. ABIN7505723
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source HEK-293 Cells
Validations
Cat. No. ABIN7505796
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Human Cells
Validations
Cat. No. ABIN7318099
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our IL12B 蛋白

Wang, Li, Ge, Li, Wang, Gao, Qiu, Liu: "Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system." in: Nature immunology, Vol. 16, Issue 3, pp. 237-45, (2015) (PubMed).

Huang, Cancilla, Morahan: "Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit." in: Genes and immunity, Vol. 1, Issue 8, pp. 515-20, (2001) (PubMed).

Prussin, Metcalfe: "Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies." in: Journal of immunological methods, Vol. 188, Issue 1, pp. 117-28, (1996) (PubMed).

Ling, Gately, Gubler, Stern, Lin, Hollfelder, Su, Pan, Hakimi: "Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 1, pp. 116-27, (1995) (PubMed).

DAndrea, Aste-Amezaga, Valiante, Ma, Kubin, Trinchieri: "Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells." in: The Journal of experimental medicine, Vol. 178, Issue 3, pp. 1041-8, (1993) (PubMed).

DAndrea, Rengaraju, Valiante, Chehimi, Kubin, Aste, Chan, Kobayashi, Young, Nickbarg: "Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells." in: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1387-98, (1992) (PubMed).

Schoenhaut, Chua, Wolitzky, Quinn, Dwyer, McComas, Familletti, Gately, Gubler: "Cloning and expression of murine IL-12." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3433-40, (1992) (PubMed).

Wolf, Temple, Kobayashi, Young, Dicig, Lowe, Dzialo, Fitz, Ferenz, Hewick: "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 9, pp. 3074-81, (1991) (PubMed).

Gubler, Chua, Schoenhaut, Dwyer, McComas, Motyka, Nabavi, Wolitzky, Quinn, Familletti: "Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 10, pp. 4143-7, (1991) (PubMed).

Aliases for IL12B 蛋白

interleukin 12B (IL12B) 蛋白
interleukin 12b (Il12b) 蛋白
interleukin 12B (Il12b) 蛋白
interleukin 12Ba (il12ba) 蛋白
CLMF 蛋白
CLMF2 蛋白
CLMF p40 蛋白
IL-12 蛋白
IL-12 p40 蛋白
IL-12.p40 蛋白
IL-12B 蛋白
Il-12b 蛋白
Il-12p40 蛋白
IL-12p40 蛋白
Il12 蛋白
il12b 蛋白
IL12B 蛋白
Il12p40 蛋白
IL12p40 蛋白
il12p40.b 蛋白
NKSF 蛋白
NKSF2 蛋白
p40 蛋白
zgc:152789 蛋白
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