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Our data demonstrated that Ctr9, independent of other PAFc subunits, controls ERalpha-target gene expression by regulating global chromatin occupancies of ERalpha and RNAPII.
Ctr9, a key subunit of hPAFc, is a central regulator of estrogen signaling that drives ERalpha (显示 ESR1 ELISA试剂盒)(+) breast tumorigenesis
Ctr9, formerly identified as a nuclei protein, interacts with the dopamine transporter in the cytoplasmic compartment.
CTR9 is a PAF1 (显示 PEX2 ELISA试剂盒) complex gene whose germline mutations predispose to Wilms tumour
CTR9, a component of PAF (显示 KIAA0101 PLURAL_@10383@) complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF (显示 NELF PLURAL_@10383@) dissociation.
MLL (显示 MLL ELISA试剂盒) interacts directly with the polymerase associated factor complex (PAFc) via Paf1 (显示 PEX2 ELISA试剂盒) and CTR9. PAFc augments MLL (显示 MLL ELISA试剂盒) and MLL (显示 MLL ELISA试剂盒)-AF9 (显示 MLLT3 ELISA试剂盒) mediated transcriptional activation of Hoxa9 (显示 HOXA9 ELISA试剂盒) and their interaction is essential for leukemogenesis.
CTR9 participates in the transcription of IL-6 (显示 IL6 ELISA试剂盒)-responsive genes through the regulation of DNA association of STAT3 (显示 STAT3 ELISA试剂盒) and modification of histone methylation
our data suggest that Setd5 is required for maintaining PGC (显示 PGC ELISA试剂盒)-associated genes and Setd5-associated protein complexes containing Tbl1xr1 (显示 TBL1XR1 ELISA试剂盒) and Ctr9, which in turn are likely involved in regulating germ cell-related genes in mESCs
these data propose a novel feed-forward loop of IL-17 (显示 IL17A ELISA试剂盒) transcriptional regulatory circuit, via IL-6 (显示 IL6 ELISA试剂盒)-mediated repression of CTR9 which is a transcriptional repressor of IL-17 (显示 IL17A ELISA试剂盒).
CTR9, parafibromin (CDC73\; MIM 607393), LEO1 (MIM 610507), and PAF1 (MIM 610506) form the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005
Ctr9, Paf1/RNA polymerase II complex component, homolog
, RNA polymerase-associated protein CTR9 homolog
, SH2 domain binding protein 1 (tetratricopeptide repeat containing)
, SH2 domain-binding protein 1
, TPR-containing, SH2-binding phosphoprotein
, TPR-containing, SH2-binding phosphoprotein of 150 kDa
, tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa
, Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
, SH2 domain binding protein 1