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Human CCL5 Protein expressed in Human Cells - ABIN2003576
Maghazachi, Al-Aoukaty, Schall: CC chemokines induce the generation of killer cells from CD56+ cells. in European journal of immunology 1996
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Cancer-FOXP3 serves as a prognostic biomarker and a crucial determinant of immunosuppressive microenvironment via recruiting Treg cells by directly trans-activating CCL5. Therefore, cancer-FOXP3 could be used to select patients with better response to CCL5/CCR5 blockade immunotherapy.
data suggest that STAT2 (显示 STAT2 蛋白) plays a role in the psoriasis pathogenesis by regulating the expression of CXCL11 (显示 CXCL11 蛋白) and CCL5, and thereby attracting IFNgamma-producing immune cells to the skin
Mean RANTES concentrations in nasal fluid in patients with perennial allergic rhinitis and nonallergic and allergic chronic rhinosinusitis with nasal polyps patients were significantly higher in comparison to control subjects.
All fatty necrotic and osteolytic jawbone (FDOJ) samples showed high expression of RANTES and fibroblast growth factor (FGF)-2 (显示 FGF2 蛋白).
This study showed that RANTES is important in the regulation of vascular dysfunction through modulation of perivascular inflammation.
These data indicate that ECFCs, not SPCs, are the major players in MMD (显示 MMD 蛋白) pathogenesis and that the chemokine (显示 CCL1 蛋白) CCL5 mediates the interactions. It can be hypothesized that in MMD (显示 MMD 蛋白) patients, defective ECFCs direct aberrant SPC (显示 UCN3 蛋白) recruitment to critical vascular locations through the action of CCL5.
miR (显示 MLXIP 蛋白)-200c represses IL-6 (显示 IL6 蛋白), IL-8 (显示 IL8 蛋白) and CCL-5 and improves osteogenic differentiation
this study shows that melanoma peptides vaccination and intratumoral administration of IFNgamma increases production of CCL5 in patient tumors
Findings indicate the importance of chemokine (CC motif) ligand 5 (CCL5) genetic variability and CCL5-CCR5 (CC chemokine receptor 5) axis on the susceptibility to HCV.
combined experimentally determined binding affinities (KD) of several orthologs of CCL5 with HNP1 (显示 DEFA1 蛋白) with in silico studies to identify the most likely heterodimeric CCL5-HNP1 (显示 DEFA1 蛋白) complex which was subsequently used as a starting structure to rationally design peptidic inhibitors
study found that the inflammatory chemokine (显示 CCL1 蛋白) CCL5 is mostly retained (75%) during the resolution of zymosan A peritonitis in mice; CCL5 exerts a novel proresolving role on macrophages when acting in concert with apoptotic PMN (显示 TBCE 蛋白)-expressed D6.
A robust up-regulation of RANTES within the brain was seen in a mouse model of tick-borne encephalitis.
CCL5 paradoxically limits macrophage accumulation in the injured kidney during renin (显示 REN 蛋白) angiotensin system (RAS) activation by constraining the proinflammatory actions of CCL2 (显示 CCL2 蛋白).
IL-6 (显示 IL6 蛋白) Mediates Macrophage Infiltration after Irradiation via Up-regulation of CCL2 (显示 CCL2 蛋白)/CCL5 in Non-small Cell Lung Cancer
Blocking antibodies against RANTES and eotaxin reduced the infiltration of CD4 (显示 CD4 蛋白)(+) and CD8 (显示 CD8A 蛋白)(+) T cells into the nigra, attenuated nigral expression of proinflammatory molecules, and suppressed nigral activation of glial cells. These findings paralleled dopaminergic neuronal protection, normalized striatal neurotransmitters, and improved motor functions in MPTP (显示 PTPN2 蛋白)-intoxicated mice.
CCL5 deficiency resulted in reduced neointima formation after carotid artery injury and thrombosis.
RANTES produced by renal tubular cells act as a key chemokine (显示 CCL1 蛋白) in acute kidney injury and HIF-1alpha (显示 HIF1A 蛋白) regulated LncRNA-PRINS might be involved in RANTES production.
Mycobacterium chelonae activates the gene expressions of chemokine (C-C motif) ligand 2 (CCL2 (显示 CCL2 蛋白)) and CCL5 in murine bone marrow-derived macrophages and in vivo mouse model.
Neutralization of circulating RANTES decreased liver neutrophilic infiltration
These results represent an important molecular mechanism whereby H. parasuis induced RANTES in the inflammatory response.
Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription.
we cloned the nucleotide sequence of the 5'-flanking region of the porcine RANTES (poRANTES) gene and characterized the regulatory elements that activate transcription
The Toll (显示 TLR4 蛋白)-like receptor signaling pathway is involved in porcine reproductive and respiratory syndrome virus-induced RANTES activation.
These results suggest that porcine RANTES can play an important role in xenotransplant rejection, through participating in the interaction between porcine endothelial cells and human monocytes.
CCL5 but not CCL2 (显示 CCL2 蛋白) mainly attract bovine classical monocytes and promote their differentiation into LPS (显示 IRF6 蛋白)-hypo-responsive macrophages.
decrease in sensitivity of HIV variants to RANTES neutralization during the course of progressive infection, but not during follow-up of long term survivors; data suggest a role for RANTES neutralization sensitivity of HIV-1 in AIDS pathogenesis
In the pathogenesis of allergic rhinitis, substance P (显示 TAC1 蛋白) induces expression of RANTES in nasal mucosa.
CCL3 (显示 CCL3 蛋白), CCL4 (显示 CCL4 蛋白) and CCL5 gene expression was evaluated in response to simian-human immunodeficiency virus (SHIV) infection in a rhesus macaque model.
This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.
chemokine (C-C motif) ligand 5
, small inducible cytokine A5
, C-C motif chemokine 5
, T-cell-specific protein RANTES
, regulated upon activation normal T-cell expressed and secreted
, small-inducible cytokine A5
, T-cell specific protein p288
, beta-chemokine RANTES
, eosinophil chemotactic cytokine
, regulated upon activation, normally T-expressed, and presumably secreted
, small inducible cytokine subfamily A (Cys-Cys), member 5
, chemokine ah294
, small inducible cytokine A5 RANTES
, chemokine CCL5/RANTES
, chemokine ligand 5