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findings provide evidence that endogenous APE1 (显示 APEX1 ELISA试剂盒) protects against ischemic infarction in both gray and white matter and facilitates the functional recovery of the central nervous system after mild stroke injury
HAP1 co-localizes with synapsin I (显示 SYN1 ELISA试剂盒) in cortical neurons as discrete puncta
Suppression of Ape1/Ref-1 (显示 APEX1 ELISA试剂盒) redox function leads to an increased cell surface retention of IL-12 (显示 IL12A ELISA试剂盒) and enhances Th1 (显示 HAND1 ELISA试剂盒) responses.
findings suggest that Hap1 is important for insulin (显示 INS ELISA试剂盒) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (显示 CACNA1C ELISA试剂盒), providing new insight into the mechanisms that regulate insulin (显示 INS ELISA试剂盒) release from pancreatic beta-cells.
Is closely associated with upregulation of the Ref1 (显示 THOC4 ELISA试剂盒)/Nrf2 (显示 NFE2L2 ELISA试剂盒) signalling pathway.
Results show the stimulatory effect of PARP-1 (显示 PARP1 ELISA试剂盒) on APE1 (显示 APEX1 ELISA试剂盒)-dependent base excision repair (BER). PARP-1 (显示 PARP1 ELISA试剂盒) and APE1 (显示 APEX1 ELISA试剂盒) appear to have a functional interaction in BER since PARP-1 (显示 PARP1 ELISA试剂盒) can stimulate the strand incision activity of APE1 (显示 APEX1 ELISA试剂盒).
Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.
Hap1 interacts with Bcr (显示 BCR ELISA试剂盒) on microtubules to regulate neuronal differentiation.
increases in APEX1 (显示 APEX1 ELISA试剂盒) level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 (显示 APEX1 ELISA试剂盒) in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells
Endothelial cell tumor proliferation was found to be dependent on Apex-1 (显示 APEX1 ELISA试剂盒) expression.
HAP1 (显示 APEX1 ELISA试剂盒) is expressed in endocrine cells of the human gut (显示 GUSB ELISA试剂盒).
data fully support that HAP1 (显示 APEX1 ELISA试剂盒) is a GKAP (显示 DLGAP1 ELISA试剂盒), anchoring specifically to the cGMP-dependent protein kinase (显示 CDK7 ELISA试剂盒) isoform Ibeta, and provide further evidence that also PKG (显示 PRKG1 ELISA试剂盒) spatiotemporal signaling is largely controlled by anchoring proteins
HAP1 (显示 APEX1 ELISA试剂盒) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity
Overexpression of HAP1 (显示 APEX1 ELISA试剂盒) reduced in vitro cell growth in breast cancer cell lines.
The results of this study found no association was found between the HAP1 (显示 APEX1 ELISA试剂盒) T441M polymorphism and the age at onset of Huntington's disease .
The results of this study suggested that HAP1 (显示 APEX1 ELISA试剂盒) co-localizes and associates with APP (显示 APP ELISA试剂盒) in physiological conditions of mouse and human brain.
WT HTT (显示 HTT ELISA试剂盒) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (显示 PCM1 ELISA试剂盒)).
HAP1 (显示 APEX1 ELISA试剂盒)/stigmoid body interacts with the normal ataxin-3 (显示 ATXN3 ELISA试剂盒) through Josephin (显示 ATXN3 ELISA试剂盒) domain
sortilin (显示 SORT1 ELISA试剂盒) stabilizes the proBDNF.HAP1 complex
ADORA2A (显示 ADORA2A ELISA试剂盒), but not HAP1 (显示 APEX1 ELISA试剂盒) or OGG1 (显示 OGG1 ELISA试剂盒), may have a role in age at onset in Huntington's disease
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
AP endonuclease 1
, APEX nuclease
, DNA-(apurinic or apyrimidinic site) lyase
, apurinic-apyrimidinic endonuclease 1
, redox factor-1
, huntingtin-associated protein 2
, neuroan 1
, huntingtin-associated protein 1 (neuroan 1)