anti-HAP1 (HAP1) 抗体产品概述

Full name:
anti-Huntingtin Associated Protein 1 抗体 (HAP1)
在www.antibodies-online.cn可供87 Huntingtin Associated Protein 1 (HAP1) 抗体的17不同的供货商。 再加上,我们可以发HAP1 蛋白 (6)HAP1 试剂盒 (4)和数多这个蛋白质的别的产品。 总共103 HAP1产品已列进来了。
别名:
APE, Apex, HAP-1, HAP1, HAP1-A, HAP1-B, HAP2, hHLP1, HIP5, HLP, Ref-1

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引用最多的anti-HAP1 抗体

  1. Human Monoclonal HAP1 Primary Antibody for ICC, FACS - ABIN259097 : Chan, Nasir, Gutekunst, Coleman, Maclean, Maas, Metzler, Gertsenstein, Ross, Nagy, Hayden: Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. in Human molecular genetics 2002 (PubMed)
    Show all 7 references for 259097

  2. Mouse (Murine) Monoclonal HAP1 Primary Antibody for IF, WB - ABIN968461 : Gutekunst, Li, Yi, Ferrante, Li, Hersch: The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 (PubMed)
    Show all 5 references for 968461

  3. Mouse (Murine) Polyclonal HAP1 Primary Antibody for EIA, WB - ABIN615992 : Rong, McGuire, Fang, Sheng, Shin, Li, Li: Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 (PubMed)
    Show all 2 references for 615992

  4. Human Polyclonal HAP1 Primary Antibody for ELISA, WB - ABIN188689 : Takeshita, Fujinaga, Zhao, Yanai, Shinoda: Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis. in Human molecular genetics 2006 (PubMed)

更多抗HAP1的相互作用对抗体

Mouse (Murine) Huntingtin Associated Protein 1 (HAP1) interaction partners

  1. findings provide evidence that endogenous APE1 (显示 APEX1 抗体) protects against ischemic infarction in both gray and white matter and facilitates the functional recovery of the central nervous system after mild stroke injury

  2. HAP1 co-localizes with synapsin I (显示 SYN1 抗体) in cortical neurons as discrete puncta

  3. Suppression of Ape1/Ref-1 (显示 APEX1 抗体) redox function leads to an increased cell surface retention of IL-12 (显示 IL12A 抗体) and enhances Th1 (显示 HAND1 抗体) responses.

  4. findings suggest that Hap1 is important for insulin (显示 INS 抗体) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (显示 CACNA1C 抗体), providing new insight into the mechanisms that regulate insulin (显示 INS 抗体) release from pancreatic beta-cells.

  5. Is closely associated with upregulation of the Ref1 (显示 THOC4 抗体)/Nrf2 (显示 NFE2L2 抗体) signalling pathway.

  6. Results show the stimulatory effect of PARP-1 (显示 PARP1 抗体) on APE1 (显示 APEX1 抗体)-dependent base excision repair (BER). PARP-1 (显示 PARP1 抗体) and APE1 (显示 APEX1 抗体) appear to have a functional interaction in BER since PARP-1 (显示 PARP1 抗体) can stimulate the strand incision activity of APE1 (显示 APEX1 抗体).

  7. Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.

  8. Hap1 interacts with Bcr (显示 BCR 抗体) on microtubules to regulate neuronal differentiation.

  9. increases in APEX1 (显示 APEX1 抗体) level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 (显示 APEX1 抗体) in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells

  10. Endothelial cell tumor proliferation was found to be dependent on Apex-1 (显示 APEX1 抗体) expression.

Human Huntingtin Associated Protein 1 (HAP1) interaction partners

  1. HAP1 (显示 APEX1 抗体) is expressed in endocrine cells of the human gut (显示 GUSB 抗体).

  2. data fully support that HAP1 (显示 APEX1 抗体) is a GKAP (显示 DLGAP1 抗体), anchoring specifically to the cGMP-dependent protein kinase (显示 CDK7 抗体) isoform Ibeta, and provide further evidence that also PKG (显示 PRKG1 抗体) spatiotemporal signaling is largely controlled by anchoring proteins

  3. HAP1 (显示 APEX1 抗体) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity

  4. Overexpression of HAP1 (显示 APEX1 抗体) reduced in vitro cell growth in breast cancer cell lines.

  5. The results of this study found no association was found between the HAP1 (显示 APEX1 抗体) T441M polymorphism and the age at onset of Huntington's disease .

  6. The results of this study suggested that HAP1 (显示 APEX1 抗体) co-localizes and associates with APP (显示 APP 抗体) in physiological conditions of mouse and human brain.

  7. WT HTT (显示 HTT 抗体) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (显示 PCM1 抗体)).

  8. HAP1 (显示 APEX1 抗体)/stigmoid body interacts with the normal ataxin-3 (显示 ATXN3 抗体) through Josephin (显示 ATXN3 抗体) domain

  9. sortilin (显示 SORT1 抗体) stabilizes the proBDNF.HAP1 complex

  10. ADORA2A (显示 ADORA2A 抗体), but not HAP1 (显示 APEX1 抗体) or OGG1 (显示 OGG1 抗体), may have a role in age at onset in Huntington's disease

HAP1 抗原简介

Antigen Summary

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Alternative names and synonyms associated with HAP1

  • apurinic/apyrimidinic endonuclease 1 (Apex1) 抗体
  • huntingtin-associated protein 1 (HAP1) 抗体
  • huntingtin-associated protein 1 (Hap1) 抗体
  • APE 抗体
  • Apex 抗体
  • HAP-1 抗体
  • HAP1 抗体
  • HAP1-A 抗体
  • HAP1-B 抗体
  • HAP2 抗体
  • hHLP1 抗体
  • HIP5 抗体
  • HLP 抗体
  • Ref-1 抗体

Protein level used designations for HAP1

AP endonuclease 1 , APEN , APEX nuclease , DNA-(apurinic or apyrimidinic site) lyase , apurinic-apyrimidinic endonuclease 1 , redox factor-1 , HAP-1 , huntingtin-associated protein 2 , neuroan 1 , huntingtin-associated protein 1 (neuroan 1)

GENE ID SPECIES
11792 Mus musculus
9001 Homo sapiens
15114 Mus musculus
29430 Rattus norvegicus
607751 Canis lupus familiaris
618422 Bos taurus
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