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Topoisomerase II alpha 蛋白

(Topoisomerase (DNA) II alpha 170kDa (TOP2A))

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010].

recommended

Topoisomerase II alpha Protein (AA 1435-1531) (GST tag) (ABIN1323347)

TOP2A 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

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Topoisomerase II alpha Protein (AA 1-1531) (Strep Tag) (ABIN3095949)

Crystallography grade TOP2A 宿主: 人宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS

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Topoisomerase II alpha Protein (AA 1-1528) (Strep Tag) (ABIN3134769)

Crystallography grade TOP2A 宿主: 小鼠宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS

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Popular Topoisomerase II alpha 蛋白

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

Topoisomerase II alpha Protein (AA 1435-1531) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1323347

Quantity 10 μg

Datasheet Datasheet

Topoisomerase II alpha Protein (AA 1-1531) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3095949

Quantity 1 mg

Datasheet Datasheet

Topoisomerase II alpha Protein (AA 1-1528) (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3134769

Quantity 1 mg

Datasheet Datasheet

Topoisomerase II alpha Protein (AA 1354-1473)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7013599

Quantity 100 μg

Datasheet Datasheet

Topoisomerase II alpha 蛋白

Reactivity Human, Mouse, Rat

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN2751809

Quantity 5 applications

Datasheet Datasheet

Aliases for Topoisomerase II alpha 蛋白

DNA topoisomerase II alpha (TOP2A) 蛋白
DNA topoisomerase II, alpha isozyme (Bm1_08705) 蛋白
topoisomerase (DNA) II alpha (Top2a) 蛋白
DNA topoisomerase II alpha (Top2a) 蛋白
topoisomerase (DNA) II alpha (TOP2A) 蛋白
Zincin-like metalloproteases family protein (AT5G10540) 蛋白
DNA topoisomerase II alpha (top2a) 蛋白
F12B17.110 蛋白
F12B17_110 蛋白
fc08c07 蛋白
thimet metalloendopeptidase 2 蛋白
Top-2 蛋白
TOP-2 蛋白
TOP2 蛋白
TOP2A 蛋白
TP2A 蛋白
wu:fc08c07 蛋白

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Aliases for Topoisomerase II alpha 蛋白

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