anti-SMAD4 (SMAD4) 抗体产品概述

Full name:
anti-SMAD Family Member 4 抗体 (SMAD4)
在www.antibodies-online.cn可供187 SMAD Family Member 4 (SMAD4) 抗体的29不同的供货商。 再加上,我们可以发SMAD4 试剂盒 (41)SMAD4 蛋白 (22)和数多这个蛋白质的别的产品。 总共271 SMAD4产品已列进来了。
别名:
AW743858, D18Wsu70e, dpc4, jip, madh4, MYHRS, smad4, Xsmad4, xsmad4a, XSmad4alpha

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引用最多的anti-SMAD4 抗体

  1. Human Polyclonal SMAD4 Primary Antibody for EIA, IHC (p) - ABIN358227 : Sekiya, Oda, Matsuura, Akiyama: Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling. in Biochemical and biophysical research communications 2004 (PubMed)
    Show all 5 references for 358227

  2. Human Polyclonal SMAD4 Primary Antibody for IF, IHC (p) - ABIN272224 : Izumi, Nakamura, Tokumo, Mano: A minute pancreatic ductal adenocarcinoma with lipomatous pseudohypertrophy of the pancreas. in JOP : Journal of the pancreas 2011 (PubMed)
    Show all 5 references for 272224

  3. Human Polyclonal SMAD4 Primary Antibody for EIA, WB - ABIN401410 : Karlsson, Blank, Moody, Ehinger, Singbrant, Deng, Karlsson: Smad4 is critical for self-renewal of hematopoietic stem cells. in The Journal of experimental medicine 2007 (PubMed)
    Show all 5 references for 401410

  4. Human Polyclonal SMAD4 Primary Antibody for ELISA, WB - ABIN1533870 : Hahn, Schutte, Hoque, Moskaluk, da Costa, Rozenblum, Weinstein, Fischer, Yeo, Hruban, Kern: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. in Science (New York, N.Y.) 1996 (PubMed)
    Show all 2 references for 1533870

  5. Human Polyclonal SMAD4 Primary Antibody for DB, IF - ABIN389658 : Maru, Wu, Canada, Houlihan, Hamilton, Rashid: Loss of chromosome 18q and DPC4 (Smad4) mutations in appendiceal adenocarcinomas. in Oncogene 2004 (PubMed)
    Show all 2 references for 389658

  6. Mouse (Murine) Polyclonal SMAD4 Primary Antibody for ELISA, WB - ABIN184619 : Kim, Fan, Papadimitrakopoulou, Clayman, Hittelman, Hong, Lotan, Mao: DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma. in Cancer research 1996 (PubMed)

  7. Cow (Bovine) Polyclonal SMAD4 Primary Antibody for WB - ABIN2779413 : Kantola, Keski-Oja, Koli: Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements. in Gene 2005 (PubMed)

  8. Human Monoclonal SMAD4 Primary Antibody for FACS - ABIN4895797 : Geng, Chen, Yuan, Peng, Maitra, Diao, Chen, Zhang, Hu, Qi, Pierce, Ling, Xiong, Li: The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis. in Nature communications 2016 (PubMed)

  9. Human Polyclonal SMAD4 Primary Antibody for IF, WB - ABIN392165 : Lessard, Rivas, Alves-Wagner, Hirshman, Gallagher, Constantin-Teodosiu, Atkins, Greenhaff, Qi, Gustafsson, Fielding, Timmons, Britton, Koch, Goodyear: Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. in Diabetes 2013 (PubMed)

  10. Cow (Bovine) Polyclonal SMAD4 Primary Antibody for IHC, WB - ABIN2780673 : Aitchison, Veerakumarasivam, Vias, Kumar, Hamdy, Neal, Mills: Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer. in The Prostate 2008 (PubMed)

更多抗SMAD4的相互作用对抗体

Human SMAD Family Member 4 (SMAD4) interaction partners

  1. Genetic status of DPC4 contributes to the recurrence patterns in pancreatic ductal adenocarcinoma following pancreatectomy, and patients with an initially expressed DPC4 gene receive a greater benefit from intensive local control for locoregional recurrence

  2. NK cells from a SMAD4-deficient person affected by polyposis were hyper-responsive to TGF-beta

  3. SMAD4 mutation was commonly detected in pancreatic juice samples from patients with Pancreatic Ductal Adenocarcinoma, mutant SMAD4 concentrations could distinguish PDAC from Intraductal Papillary Mucinous neoplasm.

  4. Phosphorylation of SMAD4 is associated with Breast Cancer Metastasis.

  5. Several germline variants in Hamartomatous Polyposis Syndrome genes were detected, among them three in ENG (显示 ENG 抗体), two in BMPR1A (显示 BMPR1A 抗体), one in PTEN (显示 PTEN 抗体), and one in SMAD4. Although some of the detected variants have been reported previously none could be definitely pathogenic or likely pathogenic.

  6. Expression levels of Smad4 and miR (显示 MLXIP 抗体)-34a in colorectal cancer patients had a significant inverse correlation and overexpressing miR (显示 MLXIP 抗体)-34a inhibited macroautophagy activation by directly targeting Smad4 through the TGF-beta (显示 TGFB1 抗体)/Smad4 pathway.

  7. MAD4 (显示 MXD4 抗体) has been found to regulate epithelial-mesenchymal transition, co-immunopurification, and glutathione S-transferase (显示 GSTa2 抗体) pull-down analysis demonstrated that USP17 interacted with SMAD4. Furthermore, USP17 stabilized SMAD4 through its deubiquitinase activity. In conclusion, this study shows that USP17 enhances osteosarcoma cell proliferation and invasion through stabilizing SMAD4.

  8. Upon SMAD4 deletion, we detected high expression levels of FYN (显示 FYN 抗体) in vessel endothelial cells, suggesting the mechanism of the ovarian tumor cells cross the endothelial barrier and transform to an invasive phenotype

  9. our data suggest that miR (显示 MLXIP 抗体)-1285-5p functions as a tumor promoter in the development of non-small-cell lung carcinoma by targeting Smad4 and CDH1 (显示 CDH1 抗体), indicating a novel therapeutic strategy for non-small-cell lung carcinoma patients.

  10. SENP1 (显示 SENP1 抗体) deSUMOylated SMAD4 to promote EMT (显示 ITK 抗体) via up-regulating E-cadherin (显示 CDH1 抗体) in prostate cancer cells. Therefore, SENP1 (显示 SENP1 抗体) is a potential target for treatment of advanced prostate cancer.

Mouse (Murine) SMAD Family Member 4 (SMAD4) interaction partners

  1. In SMAD4 deficiency, NK cells unexpectedly acquired an innate lymphoid cell type 1-like gene signature and were unable to control tumor metastasis or viral infection. Mechanistically, SMAD4 restrained non-canonical TGF-beta (显示 TGFB1 抗体) signaling mediated by the cytokine receptor (显示 LEPR 抗体) TGFbetaR1 in NK cells.

  2. The effect of Smad4 was at least partially mediated by the downstream effectors Syk (显示 SYK 抗体) and ROCK2 (显示 ROCK2 抗体) transcription in megakaryocytes

  3. deletion of Smad4 in OBs (显示 LEP 抗体) differentially modulates HSC (显示 FUT1 抗体) fate in a stage-dependent manner

  4. Data suggest that ovarian Bmp4 (显示 BMP4 抗体) levels are significantly decreased in a mouse model of polycystic ovary syndrome with hyperandrogenism; androgens inhibited Bmp4 (显示 BMP4 抗体) expression via activation of androgen receptors; Smad4 signaling rather than p38 MAPK (显示 MAPK14 抗体) pathway regulates androgen and estrogen formation.

  5. The authors demonstrated that ubiquitin-specific protease (USP) 4 (显示 USP4 抗体) strongly induces activin (显示 Actbeta 抗体)/BMP signaling by removing the inhibitory monoubiquitination from SMAD4.

  6. SMAD4 and STRA8 (显示 STRA8 抗体) are essential factors that regulate the female fate of germ cells.

  7. Smad4 is necessary for the activation of the mineralization-related genes, it is dispensable for BMP2 (显示 BMP2 抗体) to induce the protein anabolism signature, which instead critically depends on the transcription factor Atf4 (显示 ATF4 抗体).

  8. Smad4 may reduce lymphangiogenesis of colon cancer cell by attenuating VEGF-C (显示 VEGFC 抗体) secretion and act as tumor suppressor by inhibiting migration, invasion and tumorigenicity.

  9. MZF1 (显示 ZSCAN1 抗体) has a role in cellular migration of gastric cancer cells via promoting an increase in intracellular SMAD4 levels. This study might provide new evidence for the molecular basis of the tumor suppressive effect of the MZF1 (显示 ZSCAN1 抗体)-SMAD4 axis, a new therapeutic target in advanced human gastric cancer.

  10. Smad4 gene silencing may be a therapeutic target for treating ventilator-induced lung injury and pulmonary fibrosis.

Pig (Porcine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Activated TGF-beta (显示 TGFB1 抗体) signaling rescued miR (显示 MYLIP 抗体)-143-reduced FSHR (显示 FSHR 抗体) and intracellular signaling molecules, and miR (显示 MYLIP 抗体)-143-induced porcine granulosa cell apoptosis.

  2. miR26b may have a proapoptotic role in granulosa cells by regulating SMAD4 expression.

  3. These observations establish an important role of SMAD4 in the regulation of the response of porcine granulosa cells to FSH (显示 BRD2 抗体).

Cow (Bovine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Data suggest SMAD4 mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and is decreased in remaining ectogenesis; embryotrophic actions of follistatin (显示 FST 抗体) are SMAD4 dependent.

  2. ALK5 (显示 TGFBR1 抗体) and Smad4 have roles in TGF-beta1 (显示 TGFB1 抗体)-induced pulmonary endothelial permeability

Xenopus laevis SMAD Family Member 4 (SMAD4) interaction partners

  1. TGF-beta (显示 TGFB1 抗体) signaling has a role in nuclear localization of transcription factor Smad4

SMAD4 抗原简介

Antigen Summary

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Alternative names and synonyms associated with SMAD4

  • SMAD family member 4 (SMAD4) 抗体
  • Smad4 protein (smad4) 抗体
  • mothers against decapentaplegic homolog 4 (LOC100342294) 抗体
  • SMAD family member 4 (Smad4) 抗体
  • SMAD family member 4, gene 1 (smad4.1) 抗体
  • AW743858 抗体
  • D18Wsu70e 抗体
  • dpc4 抗体
  • jip 抗体
  • madh4 抗体
  • MYHRS 抗体
  • smad4 抗体
  • Xsmad4 抗体
  • xsmad4a 抗体
  • XSmad4alpha 抗体

Protein level used designations for SMAD4

Mothers against decapentaplegic-like protein 4 , mothers against decapentaplegic homolog 4 , Smad4 protein , SMAD family member 4 , mothers against decapentaplegic homolog 4-like , MAD homolog 4 , SMAD, mothers against DPP homolog 4 , deleted in pancreatic carcinoma locus 4 , deletion target in pancreatic carcinoma 4 , mothers against decapentaplegic, Drosophila, homolog of, 4 , Smad 4 , deletion target in pancreatic carcinoma 4 homolog , mothers against DPP homolog 4 , MAD (mothers against decapentaplegic Drosophila) homolog 4 , SMAD 4 , MAD, mothers against decapentaplegic homolog 4 , mothers against DPP-like 4 , mothers against decapentaplegic-like 4

GENE ID SPECIES
701803 Macaca mulatta
778905 Ciona intestinalis
100033846 Equus caballus
100409302 Callithrix jacchus
100439171 Pongo abelii
100599586 Nomascus leucogenys
100342294 Oryctolagus cuniculus
4089 Homo sapiens
17128 Mus musculus
50554 Rattus norvegicus
397142 Sus scrofa
540248 Bos taurus
476196 Canis lupus familiaris
100717853 Cavia porcellus
100861019 Capra hircus
443171 Ovis aries
780764 Xenopus laevis
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