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Rat (Rattus) SMAD2 ELISA Kit for Sandwich ELISA - ABIN432538
Kabel, Abd Elmaaboud, Albarraq: Ameliorative potential of omega 3 fatty acids and HMG-CoA reductase inhibitors on experimentally-induced non-alcoholic steatohepatitis. in Prostaglandins, leukotrienes, and essential fatty acids 2015
Human SMAD2 ELISA Kit for Sandwich ELISA - ABIN417849
Piotrowski, Kiszałkiewicz, Górski, Antczak, Górski, Pastuszak-Lewandoska, Migdalska-Sęk, Domańska-Senderowska, Nawrot, Czarnecka, Kurmanowska, Brzeziańska-Lasota: Immunoexpression of TGF-β/Smad and VEGF-A proteins in serum and BAL fluid of sarcoidosis patients. in BMC immunology 2015
The non-Smad (显示 SMAD1 ELISA试剂盒) JNK (显示 MAPK8 ELISA试剂盒) signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad (显示 SMAD1 ELISA试剂盒) pathway, and this nuclear movement is associated with Smad (显示 SMAD1 ELISA试剂盒) signal transduction toward the nucleus.
The results of this study found that Bptf and TGF-beta (显示 TGFB1 ELISA试剂盒)/Smad2 mediate nucleosome remodeling to regulate wnt8a (显示 WNT8A ELISA试剂盒) expression and hence neural posteriorization.
Smad2 and Eomesodermin (显示 EOMES ELISA试剂盒) a (Eomesa (显示 EOMES ELISA试剂盒)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (显示 EOMES ELISA试剂盒) forms a general component of the Smad2 signalling complex in zebrafish.
These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.
study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription
Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.
Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis
CRT (显示 SLC6A8 ELISA试剂盒) regulates TGF-beta1 (显示 TGFB1 ELISA试剂盒)-induced-EMT (显示 ITK ELISA试剂盒) through modulating Smad (显示 SMAD1 ELISA试剂盒) signaling
P311 (显示 C5orf13 ELISA试剂盒) is a novel TGFbeta1 (显示 TGFB1 ELISA试剂盒)/Smad (显示 SMAD1 ELISA试剂盒) signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing.
human epidermal growth factor receptor (显示 EGFR ELISA试剂盒) 2 (HER-2 (显示 ERBB2 ELISA试剂盒)) levels, were correlated well with TSP50 (显示 PRSS50 ELISA试剂盒)/p-Samd2/3 and TSP50 (显示 PRSS50 ELISA试剂盒)/p27 (显示 PAK2 ELISA试剂盒) expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50 (显示 PRSS50 ELISA试剂盒)-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer
IL-17 (显示 IL17A ELISA试剂盒) can induce A549 alveolar epithelial cells to undergo epithelial-mesenchymal transition via the TGF-beta1 (显示 TGFB1 ELISA试剂盒) mediated Smad2/3 and ERK1/2 (显示 MAPK1/3 ELISA试剂盒) activation
a critical role for miR (显示 MLXIP ELISA试剂盒)-503-3p in induction of breast cancer EMT (显示 ITK ELISA试剂盒)
Nuclear localization of Smad2 was reduced in TGFbeta (显示 TGFB1 ELISA试剂盒)-1-stimulated primary tubular epithelial cells. Changes in nuclear Smad2 correlated with a reduced expression of the pro-fibrotic factor CTGF (显示 CTGF ELISA试剂盒). Transient downregulation of Smad2 interfered with TGFbeta (显示 TGFB1 ELISA试剂盒)-1-induced CTGF (显示 CTGF ELISA试剂盒) synthesis.
Low SMAD2 expression is associated with progression of hepatic fibrosis.
In order to study the translation between mouse model and patients, we evaluated the signature of phosphorylated Sma- and Mad-related protein 2 (pSmad2), as molecular marker of TGF-beta/activin activity, in the kidneys of streptozotocin (STZ)-treated mice compared to that of type 1 diabetes (T1D) patients.
SMAD2/SMAD3 (显示 SMAD3 ELISA试剂盒) signaling by bone morphogenetic proteins causes disproportionate induction of HAS2 (显示 HAS2 ELISA试剂盒) expression and hyaluronan production in immortalized human granulosa cells.
miR (显示 MLXIP ELISA试剂盒)-27a contributed to cell proliferation and invasion by inhibiting TGF-beta (显示 TGFB1 ELISA试剂盒)-induced cell cycle arrest. These results suggest that miR (显示 MLXIP ELISA试剂盒)-27a may function as an oncogene (显示 RAB1A ELISA试剂盒) by regulating SMAD2 and SMAD4 (显示 SMAD4 ELISA试剂盒) in lung cancer.
Grg4 occupancy at the Xnr1 (显示 NODAL ELISA试剂盒) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 from FoxH1 (显示 FOXH1 ELISA试剂盒) at the Xnr1 (显示 NODAL ELISA试剂盒) enhancer, an essential feature of the transcriptional switch mechanism.
E2a (显示 TCF3 ELISA试剂盒) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis
GDF11 (显示 GDF11 ELISA试剂盒) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.
XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.
Activin A (显示 INHBA ELISA试剂盒) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (显示 NANOG ELISA试剂盒) and OCT4 (显示 POU5F1 ELISA试剂盒),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (显示 NANOG ELISA试剂盒)/OCT4 (显示 POU5F1 ELISA试剂盒) expression.
the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis
Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.
a detailed computational model for TGF-beta (显示 TGFB1 ELISA试剂盒) signalling that incorporates elements of previous models together with crosstalking between Smad1 (显示 SMAD1 ELISA试剂盒)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (显示 SMAD7 ELISA试剂盒).
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3 (显示 TPM1 ELISA试剂盒), as a model of immature Leydig cells.
Lnc-LFAR1 binds directly to Smad2/3 and promotes transcription of TGFbeta (显示 TGFB1 ELISA试剂盒), Smad2, Smad3 (显示 SMAD3 ELISA试剂盒), Notch2 (显示 NOTCH2 ELISA试剂盒) and Notch3 (显示 NOTCH3 ELISA试剂盒) which, in turn, results in TGFbeta (显示 TGFB1 ELISA试剂盒) and Notch (显示 NOTCH1 ELISA试剂盒) pathway activation.
the levels of Smad2/3, P-Smad2/3 expressions were decreased, while the level of Smad7 (显示 SMAD7 ELISA试剂盒) expression was increased after treatment with osthole.
These findings implicate TGF-beta (显示 TGFB1 ELISA试剂盒)-Smad2/3 signaling in activated tissue-resident cardiac fibroblasts as principal mediators of the fibrotic response.
selective inhibition of SMAD3 (显示 SMAD3 ELISA试剂盒) or CCT6A (显示 CCT6A ELISA试剂盒) efficiently suppresses TGF-beta (显示 TGFB1 ELISA试剂盒)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (显示 TGFB1 ELISA试剂盒) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (显示 TGFB1 ELISA试剂盒) for non-small-cell lung carcinoma.
results demonstrate that TGF-beta1 (显示 TGFB1 ELISA试剂盒)-induced autophagy links beta-catenin (显示 CTNNB1 ELISA试剂盒) and Smad (显示 SMAD1 ELISA试剂盒) signaling to promote epithelial-mesenchymal transition in C1.1 cells through a novel pY654-beta-catenin (显示 CTNNB1 ELISA试剂盒)/p-Smad2/ILK (显示 ILK ELISA试剂盒) pathway.
These results suggest that Nedd9 (显示 NEDD9 ELISA试剂盒) is a Smad2/3 target gene implicated in RANKL (显示 TNFSF11 ELISA试剂盒)-induced osteoclastogenesis.
In conclusion, TGF-beta (显示 TGFB1 ELISA试剂盒) signaling pathway may influence liver fibrosis by incorporating with YB-1 (显示 YBX1 ELISA试剂盒), indicating that YB-1 (显示 YBX1 ELISA试剂盒) could be a potential target for therapies against liver fibrosis.
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.
SMAD, mothers against DPP homolog 2
, MAD (mothers against decapentaplegic, Drosophila) homolog 2
, SMA- and MAD-related protein 2
, SMAD 2
, SMAD family member 2
, mothers against DPP homolog 2
, mothers against decapentaplegic homolog 2
, MAD homolog 2
, Sma- and Mad-related protein 2
, mother against DPP homolog 2
, mothers against decapentaplegic-like 2
, Smad 2
, mad-related protein 2