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MDM4-binding Protein 抗体

(Mdm4-binding Protein (MDM4))
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011].
MDM4-binding Protein 抗体  (AA 1-490) MDM4-binding Protein 抗体  (AA 1-490) MDM4-binding Protein 抗体 (AA 1-490) (ABIN948119)

MDM4 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated

MDM4-binding Protein 抗体 MDM4-binding Protein 抗体 MDM4-binding Protein 抗体 (ABIN969282)

MDM4 适用: 人 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 2D10F4 unconjugated

MDM4-binding Protein 抗体 MDM4-binding Protein 抗体 MDM4-binding Protein 抗体 (ABIN1499354)

MDM4 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2D11 unconjugated

MDM4-binding Protein 抗体 by 适用

Find MDM4-binding Protein 抗体 for a variety of species such as anti-Human MDM4-binding Protein, anti-Mouse MDM4-binding Protein, anti-Rat MDM4-binding Protein. The species listed below are among those available. Click on a link to go to the corresponding products.

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Find MDM4-binding Protein 抗体 validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

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Find MDM4-binding Protein 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

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Find MDM4-binding Protein 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular MDM4-binding Protein 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, IP
Validations
  • (8)
Cat. No. ABIN948119
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, ICC
Validations
  • (2)
  • (4)
Cat. No. ABIN969282
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, IHC (p)
Validations
  • (4)
Cat. No. ABIN1499354
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (1)
  • (2)
Cat. No. ABIN517808
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, IHC (p)
Validations
  • (3)
Cat. No. ABIN1499353
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7138576
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Human, Pig, Rabbit
Application WB, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN6747187
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Horse, Human, Pig, Rabbit
Application WB
Validations
  • (1)
  • (2)
Cat. No. ABIN2792185
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
  • (1)
Cat. No. ABIN872900
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7165802
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (1)
Cat. No. ABIN3185504
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN561770
Quantity 50 μL
Datasheet Datasheet
Reactivity Cow, Human, Pig, Rabbit
Application WB
Validations
  • (1)
Cat. No. ABIN202650
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IP
Validations
  • (1)
Cat. No. ABIN5583365
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN3044527
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our MDM4-binding Protein 抗体

Karki, Putra, Kim, Laquaglia, Perez-Atayde, Sadri-Vakili, Vakili: "MDM4 expression in fibrolamellar hepatocellular carcinoma." in: Oncology reports, (2019) (PubMed).

Mancini, Teveroni, Di Conza, Monteleone, Arisi, Pellegrino, Buttarelli, Pieroni, DOnofrio, Urbani, Pontecorvi, Mazzone, Moretti: "MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability." in: Molecular cancer, Vol. 16, Issue 1, pp. 55, (2017) (PubMed).

Mancini, Pieroni, Monteleone, Lucà, Fici, Luca, Urbani, Xiong, Soddu, Masetti, Lozano, Pontecorvi, Moretti: "MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response." in: Oncogene, (2015) (PubMed).

Elgohary, Pellegrino, Neumann, Elzawahry, Saber, Zeeneldin, Geffers, Ehemann, Schemmer, Schirmacher, Longerich: "Protumorigenic role of Timeless in hepatocellular carcinoma." in: International journal of oncology, Vol. 46, Issue 2, pp. 597-606, (2014) (PubMed).

Jacob, OBrien, Singh, Comiskey, Littleton, Mohammad, Gladman, Widmann, Jeyaraj, Bolinger, Anderson, Barkauskas, Boris-Lawrie, Chandler: "Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma." in: Neoplasia (New York, N.Y.), Vol. 15, Issue 9, pp. 1049-63, (2013) (PubMed).

Biderman, Poyurovsky, Assia, Manley, Prives: "MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress." in: Molecular and cellular biology, Vol. 32, Issue 7, pp. 1214-25, (2012) (PubMed).

Lee, Jin, He, Zeng, Wang, Wahl, Lu: "Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein." in: The Journal of biological chemistry, Vol. 287, Issue 25, pp. 20898-903, (2012) (PubMed).

Henze, Mühlenberg, Simon, Grabellus, Rubin, Taeger, Schuler, Treckmann, Debiec-Rychter, Taguchi, Fletcher, Bauer: "p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors." in: PLoS ONE, Vol. 7, Issue 5, pp. e37776, (2012) (PubMed).

Leventaki, Rodic, Tripp, Bayerl, Perkins, Barnette, Schiffman, Miles: "TP53 pathway analysis in paediatric Burkitt lymphoma reveals increased MDM4 expression as the only TP53 pathway abnormality detected in a subset of cases." in: British journal of haematology, Vol. 158, Issue 6, pp. 763-71, (2012) (PubMed).

Mandke, Wyatt, Fraser, Bates, Berberich, Markey: "MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame." in: PLoS ONE, Vol. 7, Issue 8, pp. e42034, (2012) (PubMed).

Aliases for MDM4-binding Protein 抗体

MDM4, p53 regulator S homeolog (mdm4.S) 抗体
MDM4, p53 regulator (MDM4) 抗体
MDM4, p53 regulator (Mdm4) 抗体
MDM4, p53 regulator (mdm4) 抗体
transformed mouse 3T3 cell double minute 4 (Mdm4) 抗体
4933417N07Rik 抗体
AA414968 抗体
AL023055 抗体
AU018793 抗体
AU021806 抗体
C85810 抗体
HDMX 抗体
mdmx 抗体
MDMX 抗体
Mdmx 抗体
MRP1 抗体
wu:fa09h09 抗体
wu:fi33d10 抗体
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