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Human FOXO3 ELISA Kit for Sandwich ELISA - ABIN1000112
Leti, Malenica, Doshi, Courtright, Van Keuren-Jensen, Legendre, Still, Gerhard, DiStefano: High-throughput sequencing reveals altered expression of hepatic microRNAs in nonalcoholic fatty liver disease-related fibrosis. in Translational research : the journal of laboratory and clinical medicine 2015
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by modulating hypoxia-inducible factor activity via up-regulation of VHL (显示 VHL ELISA试剂盒), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer
in FOXO3-death-resistant cells no point mutations in the TP53 (显示 TP53 ELISA试剂盒)-DBD were found-in these cells FOXO3-TP53 (显示 TP53 ELISA试剂盒) complexes are formed and FOXO3-binding to the BIM (显示 BCL2L11 ELISA试剂盒)-promoter, but not the induction of the detoxifying protein SESN3 (显示 SESN3 ELISA试剂盒), were prevented, which in turn increased chemo-protection in this type of high-stage-derived neuroblastoma (显示 ARHGEF16 ELISA试剂盒) cells
Taken together, these findings showed that TRIP6 (显示 TRIP6 ELISA试剂盒) plays an important role in promoting HCC (显示 FAM126A ELISA试剂盒) cells proliferation and may serve as a novel prognostic biomarker and therapeutic target in HCC (显示 FAM126A ELISA试剂盒).
NOTCH1 (显示 NOTCH1 ELISA试剂盒) inhibits activation of ATM (显示 ATM ELISA试剂盒) by impairing the formation of an ATM (显示 ATM ELISA试剂盒)-FOXO3a-KAT5 (显示 KAT5 ELISA试剂盒) complex.
FOXO3 is required to induce autophagy and thereby reduce elevated reactive oxygen species levels.
A total of 41 differentially expressed genes, such as SOCS3 (显示 SOCS3 ELISA试剂盒), VAPA (显示 VAPA ELISA试剂盒), and COL5A2 (显示 COL5A2 ELISA试剂盒), are speculated to have roles in the pathogenesis of acute myocardial infarction; 2 transcription factors FOXO3 and MYBL2 (显示 MYBL2 ELISA试剂盒), and 2 miRNAs hsa (显示 CD24 ELISA试剂盒)-miR (显示 MLXIP ELISA试剂盒)-21-5p and hsa (显示 CD24 ELISA试剂盒)-miR (显示 MLXIP ELISA试剂盒)-30c-5p may be involved in the regulation of the expression of these differentially expressed genes.
Downregulation of PKC induces senescence through the AKT (显示 AKT1 ELISA试剂盒)-FoxO3a-ROS (显示 ROS1 ELISA试剂盒)-p53 (显示 TP53 ELISA试剂盒)-p21(Cip1/WAF1 (显示 CDKN1A ELISA试剂盒)) pathway in HCT116 and HEK293 cells.
we demonstrated that REP1 blocked the nuclear trans-localization of FOXO3 through physically interacting with FOXO3, thereby suppressing FOXO3-mediated apoptosis. Importantly, the inhibition of REP1 combined with 5-FU treatment could lead to significant retarded tumor growth in a xenograft tumor model of human cancer cells
TLR4 (显示 TLR4 ELISA试剂盒) and C5aR (显示 C5AR1 ELISA试剂盒) crosstalk in dendritic cells induces a core regulatory network of RSK2 (显示 RPS6KA3 ELISA试剂盒), PI3Kbeta, SGK1 (显示 SGK1 ELISA试剂盒), and FOXO transcription factors.
FoxO3a is an early stress response protein to glucose toxicity in diabetic conditions.
Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase FBXO32/atrogin-1 (显示 FBXO32 ELISA试剂盒) and its transcription factor FOXO3A.
SIRT2 (显示 SIRT2 ELISA试剂盒) deacetylates Foxo3a, activates Bim (显示 BCL2L11 ELISA试剂盒), and induces apoptosis only in 1-methyl-4-phenylpyridinium-treated cells
MiR (显示 MLXIP ELISA试剂盒)-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a.
Our results show for the first time that DC FOXO3 expression and function is altered in females. In vitro results indicate that these differences may be the result of exposure to estrogen. These differences may be critical considerations for the enhancement of immunotherapy for cancer.
Data, including data from studies using transgenic/knockout mice, suggest that FoxO3 activation via post-translational phosphorylation can both induce and maintain autophagic activities in renal tubule epithelium in response to injury from unilateral ureteral obstruction; under these conditions, nuclear expression of FoxO3 is up-regulated in hypoxic proximal tubules exhibiting high levels of autophagy.
The Foxo3-Eomes (显示 EOMES ELISA试剂盒) pathway is central to achieve the complete specialized gene program required for pathogenic Th1 (显示 HAND1 ELISA试剂盒) cell differentiation.
these results show that Cdk5 (显示 CDK5 ELISA试剂盒)-mediated phospho-regulation of Foxo3 can activate several genes that promote neuronal death and aberrant Abeta (显示 APP ELISA试剂盒) processing, thereby contributing to the progression of neurodegenerative pathologies.
the transcription factor Forkhead box O3 (FoxO3) was found to be an essential regulator of the maintenance of pluripotency in dormant embryonic stem cells.
Loss of Foxo3 function resulted in more severe arthritis in vivo (both clinically and histologically) and was associated with higher titers of anticollagen antibodies and interleukin-6 (显示 IL6 ELISA试剂盒) in the blood.
results indicate that DNA damage accrued as a result of elevated ROS in Foxo3(-/-) mutant HSPC is at least partially reversible
These results indicate that myostatin (显示 MSTN ELISA试剂盒) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (显示 NR3C1 ELISA试剂盒) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN, FOXO3A and PKB (显示 AKT1 ELISA试剂盒) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
NO/protein kinase (显示 CDK7 ELISA试剂盒) G (PKG (显示 PRKG1 ELISA试剂盒))-dependent downregulation of PGC-1 alpha (显示 PPARGC1A ELISA试剂盒) and the ROS (显示 ROS1 ELISA试剂盒) detoxification system in endothelial cells are mediated by the PI3K/Akt (显示 AKT1 ELISA试剂盒) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (显示 ROS1 ELISA试剂盒)-induced apoptosis in mammalian cells.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like