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metabolic function of cyclin D3-CDK6 (显示 CDK6 ELISA试剂盒) kinase in cancer cell survival
we showed that ZNF224 positively modulates cyclin D3 gene expression. Consistently, we observed that alteration of ZNF224 expression leads to defects in cell cycle control. All together, our results strongly suggest that in Chronic lymphocytic leukaemia (CLL)cells high expression level of ZNF224 can lead to inappropriate cell growth and apoptosis resistance, thus contributing to CLL progression
the activation of TLR7 (显示 TLR7 ELISA试剂盒) increased CCND3 expression via the downregulation of miR (显示 MLXIP ELISA试剂盒)-15b in B cells.
This study describes the identification and characterization of cyclin D3 as a novel interactor of influenza A virus M2 protein.
MicroRNA-138 interacts with cyclin D3 and negatively regulates non-small cell lung cancer cells
Combined urinary FGFR3 (显示 FGFR3 ELISA试剂盒)/Cyclin D3 expression shows improved detection rates for bladder cancer recurrence with high specificity and sensitivity.
cyclin-D1 (显示 CCND1 ELISA试剂盒) and cyclin-D3 within human islet cells varies according to the status of the pancreas donor
The CDK6 (显示 CDK6 ELISA试剂盒)-cyclin D3 pair play a fundamental role in controlling CDK2 (显示 CDK2 ELISA试剂盒)-dependent SAMHD1 (显示 SAMHD1 ELISA试剂盒) phosphorylation and the dNTP pool in primary macrophages.
Two recurrent fusion genes associated with the 12q locus, LRP1 (显示 LRP1 ELISA试剂盒)-SNRNP25 (显示 SNRNP25 ELISA试剂盒) and KCNMB4 (显示 KCNMB4 ELISA试剂盒)-CCND3, were by RT-PCR, Sanger sequencing and FISH, and were found to be osteosarcoma specific in a validation cohort of 240 other sarcomas.
G1 arrest induced by SB265610 occurred at concentrations lacking CXCR2 (显示 CXCR2 ELISA试剂盒) selectivity and revealed cyclin-dependent kinase 2 (CDK2 (显示 CDK2 ELISA试剂盒)) (Thr160) hypophosphorylation, cyclin D3 gene down-regulation, and p21 (显示 CDKN1A ELISA试剂盒) post-translational induction
The swine UCHL3 (显示 Uchl3 ELISA试剂盒), RIT1 (显示 RIT1 ELISA试剂盒) and CCND3 genes were found to be differentially expressed in tissues including small intestine, large intestine, liver, muscle, fat, lung, spleen and kidney.
These results suggest that progesterone receptor (显示 PGR ELISA试剂盒) overexpression in endometrial stromal cells, likely due to high progesterone levels, triggers cyclin D3 and Hoxa-10 (显示 HOXA10 ELISA试剂盒) overexpression, which may be involved in the pathological mechanisms of the mouse uterine decidual reaction.
immature B and T cells use lymphocyte lineage- and developmental stage-specific mechanisms to inhibit Cyclin D3 protein levels.
we suggest that proper regional decidualization and polyploidy development requires FoxM1 (显示 FOXM1 ELISA试剂盒) signaling downstream of Hoxa10 (显示 HOXA10 ELISA试剂盒) and cyclin D3.
Cyclin D3 protein that drives immature T cell proliferation is essential for transformation of Atm (显示 ATM ELISA试剂盒)-deficient thymocytes
DYRK1A (显示 DYRK1A ELISA试剂盒) has a role in lymphopoiesis; Cyclin D3 protein stability is negatively regulated during exit from the proliferative phases of B and T cell development
inactivation of Ccnd3 leads to increased frequencies of lymphocytes with biallelic expression of IgH or TCRbeta genes.
FGF2 signaling results in the phosphorylation of Erk1/2, and activation of c-Fos and c-Jun that lead to elevated cyclin D mRNA levels.
Results indicate that cyclin D3 plays a cell-autonomous and nonredundant function in regulating the dynamic balance between proliferation, differentiation, and self-renewal that normally establishes an appropriate pool size of adult satellite cells.
Investigated the expression of GABA and GABPR in the early-pregnancy mouse uterus. Cyclin D3 was measured in cultured stromal cells artificially induced to undergo decidualization, by GABA and a GABA A-type receptor agonist or antagonist.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.
, G1/S-specific cyclin-D3
, D3-type cyclin
, G1/S-specific cyclin D3