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We unexpectedly found that p19INK4d plays an important role in human terminal erythropoiesis
p19(INK4D) is one of the key mediators of miR (显示 MLXIP ELISA试剂盒)-125b activity during the onset of megakaryocyte polyploidization.
p19 may play an important role in the ototoxic effects of cisplatin and is probably involved in the pathogenesis of hearing loss.
MiR (显示 MLXIP ELISA试剂盒)-451 inhibited the proliferation of esophageal squamous cell carcinoma cells by targeting CDKN2D and MAP3K1 (显示 MAP3K1 ELISA试剂盒) expression.
Data indicate that upon oxidative DNA damage, cyclin-dependent kinase (显示 CDK1 ELISA试剂盒) inhibitor p19INK4d strongly binds to and relaxes chromatin.
CDKN2D repression by PML (显示 PML ELISA试剂盒)/RARalpha (显示 RARA ELISA试剂盒) disrupts both cell proliferation and differentiation in the pathogenesis of acute promyelocytic leukemia (显示 PML ELISA试剂盒).
p19-INK4d inhibits neuroblastoma (显示 ARHGEF16 ELISA试剂盒) cell growth, induces differentiation and is hypermethylated and downregulated in MYCN (显示 MYCN ELISA试剂盒)-amplified neuroblastomas.
CDKN2D-WDFY2 (显示 ZFYVE22 ELISA试剂盒) fusion could be an important molecular signature for understanding and classifying sub-lineages among heterogeneous high-grade serous ovarian carcinomas.
Mutations in CDKN2D is associated with sporadic parathyroid adenoma.
P19(INK4d) expression is a poor prognostic factor in ovarian cancer patients.
The expression of three tumor suppressor genes encoded in the INK4/ARF locus (p15(INK4b (显示 CDKN2B ELISA试剂盒)), p16(INK4a), and p19(ARF)) was decreased in E6AP (显示 ube3a ELISA试剂盒)(-/-) embryo fibroblasts.
TWIST1 (显示 TWIST1 ELISA试剂盒)-E protein heterodimeric complexes may thus constitute the main active forms of TWIST1 (显示 TWIST1 ELISA试剂盒) with regard to senescence inhibition over the time course of breast tumorigenesis.
Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase (显示 CDK1 ELISA试剂盒) inhibitor p19Ink4d.
p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging
Cdk4 (显示 CDK4 ELISA试剂盒) and Cdk6 (显示 CDK6 ELISA试剂盒) cooperate in hematopoietic tumor development and suggest a role for Cdk6 (显示 CDK6 ELISA试剂盒) in sequestering INK4 proteins away from Cdk4 (显示 CDK4 ELISA试剂盒).
Deletion of p19(Ink4d) (p19), a cyclin-dependent kinase (显示 CDK1 ELISA试剂盒) CDK (显示 CDK4 ELISA试剂盒) inhibitor gene, in mice results in spontaneous development of tumors in multiple organs and tissues.
We propose that p19INK4d participates in the cellular mechanisms that trigger senescence by contributing to chromatin compaction
CDK5 (显示 CDK5 ELISA试剂盒)-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions.
an asymmetrical distribution pattern for Cdkn2d transcripts in 2-cell embryos.
Ectopic expression of RUVBL2 decreases the levels of ARF, whereas knockdown of RUVBL2 results in a marked increase in ARF levels. In addition, RUVBL2 down-regulates the levels of p53 in an ARF-dependent manner.
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
, cyclin-dependent kinase 4 inhibitor D
, Cyclin-dependent kinase 4 inhibitor D
, CDK inhibitor p19INK4d
, cell cycle inhibitor, Nur77 associating protein
, cyclin-dependent kinase 4 inhibitor D p19
, inhibitor of cyclin-dependent kinase 4d