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These results provided evidence supporting the oncogenic potential of NFAT3 (显示 NFATC4 ELISA试剂盒) and suggested that CDK3 (显示 CDK3 ELISA试剂盒)-mediated phosphorylation of NFAT3 (显示 NFATC4 ELISA试剂盒) has an important role in skin tumorigenesis.
The analysis of tumor and matched normal lung tissues indicates that miR (显示 MLXIP ELISA试剂盒)-150 downregulation in lung tumors correlates with higher CDK3 (显示 CDK3 ELISA试剂盒) levels. In addition, miR (显示 MLXIP ELISA试剂盒)-150 transfection experiments with cancer-derived cell lines reveal that miR (显示 MLXIP ELISA试剂盒)-150-mediated CDK3 (显示 CDK3 ELISA试剂盒) suppression directly induces growth inhibition.
High Cdk3 (显示 CDK3 ELISA试剂盒)-promoted epithelial-mesenchymal transition through activating AP-1 (显示 FOSB ELISA试剂盒) is involved in colorectal cancer metastasis.
Data indicate that microRNA miR (显示 MLXIP ELISA试剂盒)-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC (显示 FAM126A ELISA试剂盒)) through inhibition of E2F2 transcription factor (E2F2 (显示 E2F2 ELISA试剂盒)), cyclin (显示 PCNA ELISA试剂盒)-dependent kinases CDK3 (显示 CDK3 ELISA试剂盒) and CDK6 (显示 CDK6 ELISA试剂盒).
Mir (显示 MLXIP ELISA试剂盒)-873 inhibits ESR1 (显示 ESR1 ELISA试剂盒) activity and cell growth via targeting CDK3 (显示 CDK3 ELISA试剂盒).
CDK3 (显示 CDK3 ELISA试剂盒) is associated with the progression of NPC (显示 NPC1 ELISA试剂盒), and may be a potential biomarker for prediction of the prognosis of patients with NPC (显示 NPC1 ELISA试剂盒).
The Walleye dermal sarcoma virus cyclin (显示 PCNA ELISA试剂盒) functions as a structural ortholog of cyclin C (显示 CCNC ELISA试剂盒) in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 (显示 CDK8 ELISA试剂盒) and Cdk3 (显示 CDK3 ELISA试剂盒).
NKIAMRE is a member of a conserved family of kinases with homology to both MAP kinases and cyclin (显示 PCNA ELISA试剂盒)-dependent kinases
cdkl3 transfected in anchorage-independent (suspension) HeLa cells overexpressed relative to attached cells and lead to elevated proliferation and faster transition G0/G1 phases to S phase relative to controls. Same in two HEK (显示 EPHA3 ELISA试剂盒)-293 and a CHO (显示 COL11A1 ELISA试剂盒) cell lines.
data suggest that the CDKL3 gene is a strong candidate for nonsyndromal autosomal dominant mild mental retardation
Results indicated that CDKL3 may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo st
CDKL3 is involved in neuronal morphogenesis during development.
The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms.
serine-threonine protein kinase NKIAMRE
, serine/threonine-protein kinase NKIAMRE
, serine/threonine kinase NKIATRE beta
, serine/threonine protein kinase NKIATRE
, cyclin-dependent kinase-like 3