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These results provided evidence supporting the oncogenic potential of NFAT3 (显示 NFATC4 ELISA试剂盒) and suggested that CDK3-mediated phosphorylation of NFAT3 (显示 NFATC4 ELISA试剂盒) has an important role in skin tumorigenesis.
The analysis of tumor and matched normal lung tissues indicates that miR (显示 MLXIP ELISA试剂盒)-150 downregulation in lung tumors correlates with higher CDK3 levels. In addition, miR (显示 MLXIP ELISA试剂盒)-150 transfection experiments with cancer-derived cell lines reveal that miR (显示 MLXIP ELISA试剂盒)-150-mediated CDK3 suppression directly induces growth inhibition.
High Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 (显示 FOSB ELISA试剂盒) is involved in colorectal cancer metastasis.
Data indicate that microRNA miR (显示 MLXIP ELISA试剂盒)-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC (显示 FAM126A ELISA试剂盒)) through inhibition of E2F2 transcription factor (E2F2 (显示 E2F2 ELISA试剂盒)), cyclin (显示 PCNA ELISA试剂盒)-dependent kinases CDK3 and CDK6 (显示 CDK6 ELISA试剂盒).
Mir (显示 MLXIP ELISA试剂盒)-873 inhibits ESR1 (显示 ESR1 ELISA试剂盒) activity and cell growth via targeting CDK3.
CDK3 is associated with the progression of NPC (显示 NPC1 ELISA试剂盒), and may be a potential biomarker for prediction of the prognosis of patients with NPC (显示 NPC1 ELISA试剂盒).
The Walleye dermal sarcoma virus cyclin (显示 PCNA ELISA试剂盒) functions as a structural ortholog of cyclin C (显示 CCNC ELISA试剂盒) in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 (显示 CDK8 ELISA试剂盒) and Cdk3.
A non-cdk8 (显示 CDK8 ELISA试剂盒)-associated cellular pool of cyclin C (显示 CCNC ELISA试剂盒) combines with cdk3 to stimulate pRb (显示 RB1 ELISA试剂盒) phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently.
Expression level of cdk3 is higher in human cancer cell lines and glioblastoma tissue compared with normal brain tissue. cdk3 phosphorylates activating transcription factor 1 (ATF1 (显示 AFT1 ELISA试剂盒))and enhances the transactivation and transcriptional activities of ATF1 (显示 AFT1 ELISA试剂盒).
Results indicated that CDKL3 (显示 CDKL3 ELISA试剂盒) may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo st
CDKL3 (显示 CDKL3 ELISA试剂盒) is involved in neuronal morphogenesis during development.
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.
cyclin-dependent kinase 3
, cell division protein kinase 3