Cell Division Cycle

Any growing organism – regardless of it being single- or multi-cellular – rests upon the reiteration the growth and division of existing cells under favorable conditions. During each round of this process, the cell cycles through an ordered series of events in which its genetic information is duplicated and then splits up into two cells. These events are tightly regulated and certain checkpoints must be passed in order for the cell cycle to be completed. The loss of control of these processes is a hallmark of cancer.

The cell cycle is split up into four major phases based on the events unfolding in the cell. During the first gap phase (G1) the proteins are produced that are essential for DNA replication. The genetic information is then being replicated during the synthesis (S) phase. In the second gap phase (G2) all the components that are necessary for the separation of the duplicated DNA during the subsequent mitosis (M phase). Cells that are not actively dividing are considered to be in a quiescent state in the resting phase G0. Two checkpoints between G1/S and G2/M phase must be passed in order for the cell cycle to progress.

Once replication, DNA replication must be finished. Therefore, the major checkpoint in the cell cycle is the restriction (R) point between G1 and S phases, prior to DNA duplication, at which the cycle progresses depending on mitogenic or inhibitory factors such as DNA damage and signals from various signaling pathways. A second checkpoint is at the intersection between G2 and M phases. Progression from one phase to another is controlled by cyclin dependent kinases (CDK) and their activators, cyclins. Latter proteins are unstable and their cellular concentration cycles throughout the cell cycle. Accordingly, specific cyclin-CDK complexes are characteristic for the different cell cycle phases. In addition, their activity is further modulated by CDK inhibitors. Collectively, these factors maintain balance on a cellular level and beyond.

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Cyclin Dependent Kinase

CDK1 (Cyclin-Dependent Kinase 1):

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity...   更多...

CDK2 (Cyclin-Dependent Kinase 2):

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and...   更多...

CDK4 (Cyclin-Dependent Kinase 4):

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S....

CDK6 (Cyclin-Dependent Kinase 6):

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene...
此分类里的别的抗原:
CDK2AP2 (Cyclin-Dependent Kinase 2 Associated Protein 2): CDK2AP2 抗体 CDK2AP2 ELISA试剂盒 CDK2AP2 蛋白
CDK3 (Cyclin-Dependent Kinase 3): CDK3 抗体 CDK3 ELISA试剂盒 CDK3 蛋白
CDKL3 (Cyclin-Dependent Kinase-Like 3): CDKL3 抗体 CDKL3 ELISA试剂盒 CDKL3 蛋白
CDK5 (Cyclin-Dependent Kinase 5): CDK5 抗体 CDK5 ELISA试剂盒 CDK5 蛋白
CDK7 (Cyclin-Dependent Kinase 7): CDK7 抗体 CDK7 ELISA试剂盒 CDK7 蛋白
CDK8 (Cyclin-Dependent Kinase 8): CDK8 抗体 CDK8 ELISA试剂盒 CDK8 蛋白
CDK9 (Cyclin-Dependent Kinase 9): CDK9 抗体 CDK9 ELISA试剂盒 CDK9 蛋白

Cyclins

CCNB1 - Cyclin B1

The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of...   更多...

CCNE1 - Cyclin E1

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex...   更多...

CCNB2 - Cyclin B2

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are...

CCNE2 - Cyclin E2

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in...
此分类里的别的抗原:
CCNA1 - Cyclin A1: CCNA1 抗体 CCNA1 ELISA试剂盒 CCNA1 蛋白
CCNA2 - Cyclin A: CCNA2 抗体 CCNA2 ELISA试剂盒 CCNA2 蛋白
CCNB3 - Cyclin B3: CCNB3 抗体 CCNB3 ELISA试剂盒 CCNB3 蛋白
CCNC - Cyclin C: CCNC 抗体 CCNC ELISA试剂盒 CCNC 蛋白
CCND1 - Cyclin D1: CCND1 抗体 CCND1 ELISA试剂盒 CCND1 蛋白
CCND2 - Cyclin D2: CCND2 抗体 CCND2 ELISA试剂盒 CCND2 蛋白
CCND3 - Cyclin D3: CCND3 抗体 CCND3 ELISA试剂盒 CCND3 蛋白
CCNH - Cyclin H: CCNH 抗体 CCNH ELISA试剂盒 CCNH 蛋白
CCNI - Cyclin I: CCNI 抗体 CCNI ELISA试剂盒 CCNI 蛋白

G1-S Checkpoint

CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe)):

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although...   更多...

CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4)):

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This...

CDKN1A (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1)):

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4...
此分类里的别的抗原:
FOXO1 (Forkhead Box O1): FOXO1 抗体 FOXO1 ELISA试剂盒 FOXO1 蛋白
FOXO3 (Forkhead Box O3): FOXO3 抗体 FOXO3 ELISA试剂盒 FOXO3 蛋白
FOXO4 (Forkhead Box O4): FOXO4 抗体 FOXO4 ELISA试剂盒 FOXO4 蛋白
SMAD2 (SMAD, Mothers Against DPP Homolog 2): SMAD2 抗体 SMAD2 ELISA试剂盒 SMAD2 蛋白
SMAD3 (SMAD, Mothers Against DPP Homolog 3): SMAD3 抗体 SMAD3 ELISA试剂盒 SMAD3 蛋白
SMAD4 (SMAD Family Member 4): SMAD4 抗体 SMAD4 ELISA试剂盒 SMAD4 蛋白
BMI1 (BMI1 Polycomb Ring Finger Oncogene): BMI1 抗体 BMI1 ELISA试剂盒 BMI1 蛋白
MNAT1 (Menage A Trois Homolog 1, Cyclin H Assembly Factor (Xenopus Laevis)): MNAT1 抗体 MNAT1 ELISA试剂盒 MNAT1 蛋白
CDC25B (Cell Division Cycle 25 Homolog B (S. Pombe)): CDC25B 抗体 CDC25B ELISA试剂盒 CDC25B 蛋白
CDC25C (Cell Division Cycle 25 Homolog C (S. Pombe)): CDC25C 抗体 CDC25C ELISA试剂盒 CDC25C 蛋白
RASGRF1 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1): RASGRF1 抗体 RASGRF1 ELISA试剂盒 RASGRF1 蛋白
CDKN2C (Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4)): CDKN2C 抗体 CDKN2C ELISA试剂盒 CDKN2C 蛋白
CDKN2D (Cyclin-Dependent Kinase Inhibitor 2D (p19, Inhibits CDK4)): CDKN2D 抗体 CDKN2D ELISA试剂盒 CDKN2D 蛋白
CDKN1A (Cyclin-Dependent Kinase Inhibitor 1A): CDKN1A 抗体 CDKN1A ELISA试剂盒 CDKN1A 蛋白
CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1)): CDKN1B 抗体 CDKN1B ELISA试剂盒 CDKN1B 蛋白
CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2)): CDKN1C 抗体 CDKN1C ELISA试剂盒 CDKN1C 蛋白
MYC - C-MYC: MYC 抗体 MYC ELISA试剂盒 MYC 蛋白

E2F/RB

RB1 - Retinoblastoma 1

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder...   更多...

E2F1 (E2F Transcription Factor 1):

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a...   更多...
此分类里的别的抗原:
E2F2 (E2F Transcription Factor 2): E2F2 抗体 E2F2 ELISA试剂盒 E2F2 蛋白
E2F4 (E2F Transcription Factor 4, P107/p130-Binding): E2F4 抗体 E2F4 ELISA试剂盒 E2F4 蛋白
TFDP1 - DP1: TFDP1 抗体 TFDP1 ELISA试剂盒 TFDP1 蛋白
TFDP2 - DP2: TFDP2 抗体 TFDP2 ELISA试剂盒 TFDP2 蛋白
RBL1 - p107: RBL1 抗体 RBL1 ELISA试剂盒 RBL1 蛋白
RBL2 - p130: RBL2 抗体 RBL2 ELISA试剂盒 RBL2 蛋白

G2-M Checkpoint

CHEK1 (Checkpoint Kinase 1):

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response...

CHEK2 (Checkpoint Kinase 2):

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The...
此分类里的别的抗原:
MNAT1 (Menage A Trois Homolog 1, Cyclin H Assembly Factor (Xenopus Laevis)): MNAT1 抗体 MNAT1 ELISA试剂盒 MNAT1 蛋白
CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe)): CDC25A 抗体 CDC25A ELISA试剂盒 CDC25A 蛋白
CDC25B (Cell Division Cycle 25 Homolog B (S. Pombe)): CDC25B 抗体 CDC25B ELISA试剂盒 CDC25B 蛋白
CDC25C (Cell Division Cycle 25 Homolog C (S. Pombe)): CDC25C 抗体 CDC25C ELISA试剂盒 CDC25C 蛋白
RASGRF1 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1): RASGRF1 抗体 RASGRF1 ELISA试剂盒 RASGRF1 蛋白
WEE1 (WEE1 Homolog (S. Pombe)): WEE1 抗体 WEE1 ELISA试剂盒 WEE1 蛋白
MYT1 (Myelin Transcription Factor 1): MYT1 抗体 MYT1 ELISA试剂盒 MYT1 蛋白
PLK1 (Polo-Like Kinase 1): PLK1 抗体 PLK1 ELISA试剂盒  
PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D): PPM1D 抗体 PPM1D ELISA试剂盒 PPM1D 蛋白
GADD45A (Growth Arrest and DNA-Damage-Inducible, alpha): GADD45A 抗体 GADD45A ELISA试剂盒 GADD45A 蛋白
GADD45B (Growth Arrest and DNA-Damage-Inducible, beta): GADD45B 抗体 GADD45B ELISA试剂盒 GADD45B 蛋白
GADD45G (Growth Arrest and DNA-Damage-Inducible, gamma): GADD45G 抗体 GADD45G ELISA试剂盒 GADD45G 蛋白
MDM4 - MDM4-binding Protein: MDM4 抗体 MDM4 ELISA试剂盒 MDM4 蛋白
BRCA1 (Breast Cancer 1): BRCA1 抗体 BRCA1 ELISA试剂盒 BRCA1 蛋白
RBBP8 - Retinoblastoma Binding Protein 8: RBBP8 抗体 RBBP8 ELISA试剂盒 RBBP8 蛋白
HIPK2 (Homeodomain Interacting Protein Kinase 2): HIPK2 抗体 HIPK2 ELISA试剂盒 HIPK2 蛋白
TOP2A - Topoisomerase II alpha: TOP2A 抗体 TOP2A ELISA试剂盒 TOP2A 蛋白
TERF1 - TRF1: TERF1 抗体 TERF1 ELISA试剂盒 TERF1 蛋白
TERF2 - TRF2: TERF2 抗体 TERF2 ELISA试剂盒 TERF2 蛋白
TINF2 (TIN2): TINF2 抗体 TINF2 ELISA试剂盒 TINF2 蛋白
TPP1 (Tripeptidyl Peptidase I): TPP1 抗体 TPP1 ELISA试剂盒 TPP1 蛋白
POT1 (Protection of Telomeres 1): POT1 抗体    
POT1 (Protection of Telomeres 1 Homolog (S. Pombe)): POT1 抗体 POT1 ELISA试剂盒 POT1 蛋白
TERF2IP - RAP1: TERF2IP 抗体 TERF2IP ELISA试剂盒 TERF2IP 蛋白
AURKA - Aurora A: AURKA 抗体 AURKA ELISA试剂盒 AURKA 蛋白
CDKN1A (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1)): CDKN1A 抗体 CDKN1A ELISA试剂盒 CDKN1A 蛋白
CDKN1A (Cyclin-Dependent Kinase Inhibitor 1A): CDKN1A 抗体 CDKN1A ELISA试剂盒 CDKN1A 蛋白
MDM2 (Mdm2 P53 Binding Protein Homolog (Mouse)):   MDM2 ELISA试剂盒  
MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse)): MDM2 抗体 MDM2 ELISA试剂盒 MDM2 蛋白

M Phase

INCENP (Inner Centromere Protein Antigens 135/155kDa):

In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A\; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses...   更多...
此分类里的别的抗原:
AURKB - Aurora Kinase B: AURKB 抗体 AURKB ELISA试剂盒 AURKB 蛋白
AURKC - Aurora Kinase C: AURKC 抗体 AURKC ELISA试剂盒 AURKC 蛋白
CDCA8 (Cell Division Cycle Associated 8): CDCA8 抗体 CDCA8 ELISA试剂盒 CDCA8 蛋白
BIRC5 (Baculoviral IAP Repeat-Containing 5): BIRC5 抗体 BIRC5 ELISA试剂盒 BIRC5 蛋白
EPR1 (Early-Phytochrome-Responsive1): EPR1 抗体    

CSN Complex

GPS1 (G Protein Pathway Suppressor 1):

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant...

COPS6 (COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis)):

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an...
此分类里的别的抗原:
COPS2 - COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis): COPS2 抗体 COPS2 ELISA试剂盒 COPS2 蛋白
COPS3 (COP9 Constitutive Photomorphogenic Homolog Subunit 3 (Arabidopsis)): COPS3 抗体 COPS3 ELISA试剂盒 COPS3 蛋白
COPS4 (COP9 Constitutive Photomorphogenic Homolog Subunit 4 (Arabidopsis)): COPS4 抗体 COPS4 ELISA试剂盒 COPS4 蛋白
COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis)): COPS5 抗体 COPS5 ELISA试剂盒 COPS5 蛋白
COPS7A (COP9 Constitutive Photomorphogenic Homolog Subunit 7A (Arabidopsis)): COPS7A 抗体   COPS7A 蛋白
COPS7B (COP9 Constitutive Photomorphogenic Homolog Subunit 7B (Arabidopsis)): COPS7B 抗体 COPS7B ELISA试剂盒 COPS7B 蛋白
COPS8 (COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis)): COPS8 抗体 COPS8 ELISA试剂盒 COPS8 蛋白

SCF Complex

CUL1 - Cullin 1

Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the...   更多...
此分类里的别的抗原:
SKP1 (S-Phase Kinase-Associated Protein 1): SKP1 抗体 SKP1 ELISA试剂盒 SKP1 蛋白
RBX1 (Ring-Box 1, E3 Ubiquitin Protein Ligase): RBX1 抗体 RBX1 ELISA试剂盒 RBX1 蛋白
BTRC (beta-Transducin Repeat Containing): BTRC 抗体 BTRC ELISA试剂盒 BTRC 蛋白

DREAM complex

RBL1 - p107

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene...

RBL2 - p130

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in...

E2F4 (E2F Transcription Factor 4, P107/p130-Binding):

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell...

TFDP1 - DP1

This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and...
此分类里的别的抗原:
TFDP2 - DP2: TFDP2 抗体 TFDP2 ELISA试剂盒 TFDP2 蛋白
TFDP3 (Transcription Factor Dp Family, Member 3): TFDP3 抗体   TFDP3 蛋白
LIN9 (Lin-9 Homolog (C. Elegans)): LIN9 抗体 LIN9 ELISA试剂盒 LIN9 蛋白
LIN37 (Lin-37 Homolog (C. Elegans)): LIN37 抗体 LIN37 ELISA试剂盒 LIN37 蛋白
LIN54 (Lin-54 Homolog (C. Elegans)): LIN54 抗体 LIN54 ELISA试剂盒 LIN54 蛋白
RBBP4 - Retinoblastoma Binding Protein 4: RBBP4 抗体 RBBP4 ELISA试剂盒 RBBP4 蛋白
MSI3 (Histone-Binding Protein RBBP4):   MSI3 ELISA试剂盒 MSI3 蛋白
MYBL1 (Myb-Like Protein 1): MYBL1 抗体 MYBL1 ELISA试剂盒 MYBL1 蛋白
MYBL2 (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2): MYBL2 抗体 MYBL2 ELISA试剂盒 MYBL2 蛋白