anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 (MLLT4) 抗体产品概述

在www.antibodies-online.cn可供41 Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 (MLLT4) 抗体的16不同的供货商。 总共42 Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4产品已列进来了。
别名:
5033403D15Rik, Af-6, Af6, Afadin, Gm314, I-afadin, MLLT4, RP3-431P23.3, S-afadin, si:ch211-278j12.1
列出全部抗体 基因 基因ID UniProt
MLLT4 4301 P55196
MLLT4 17356 Q9QZQ1
MLLT4 26955 O35889

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更多抗Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4的相互作用对抗体

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 (MLLT4) interaction partners

  1. Afadin (AFDN), a cytoskeletal and junction-associated protein, was present in 2D and 3D keratinocyte cultures, and validated as a so-far-unknown EphA2 (显示 EPHA2 抗体)-interacting protein.

  2. In pancreatic cancer cells, AF6 is expressed at reduced levels, causing Dvl2 (显示 DVL2 抗体) to be upregulated and available to bind and enhance FOXE1 (显示 FOXE1 抗体)-induced trans-activation of Snail (显示 SNAI1 抗体), which promotes proliferation and metastasis.

  3. AF-6/afadin could be a useful selection marker for fertility-sparing therapy for patients with atypical hyperplasia or grade 1 endometrioid adenocarcinoma with no myometrial invasion.

  4. JAM-A (显示 F11R 抗体) regulates epithelial permeability via association with ZO-2 (显示 TJP2 抗体), afadin, and PDZ-GEF1 (显示 RAPGEF2 抗体) to activate Rap2c (显示 RAP2C 抗体) and control contraction of the apical cytoskeleton.

  5. MLL (显示 MLL 抗体)-AF6 oncoprotein potentiates the activity of the RAS pathway through retention of AF6 within the nucleus.

  6. The expression levels of CFTR (显示 CFTR 抗体) and AF-6/afadin are significantly downregulated in human colon cancer tissues.

  7. AF-6 is a positive modulator of the PINK1 (显示 PINK1 抗体)/parkin (显示 PARK2 抗体) pathway and is deficient in Parkinson's disease.

  8. The interaction between the PDZ domain (显示 INADL 抗体) of afadin (AF6_PDZ) and a series of polypeptides comprising the PDZ (显示 INADL 抗体)-binding motif, was studied.

  9. Results demonstrate a role for afadin in the regulation of vascular barrier function via coordination of adherens junction-tight junction and p120-catenin (显示 CTNND1 抗体)-ZO-1 (显示 TJP1 抗体) interactions.

  10. the Necl-5 (显示 PVR 抗体)-nectin (显示 PVRL1 抗体), nectin-nectin (显示 PVRL1 抗体), and nectin (显示 PVRL1 抗体)-afadin interactions cooperatively increase the clustering of the nectin (显示 PVRL1 抗体)-afadin complex at the cell-cell contact sites, promoting the formation of the nectin (显示 PVRL1 抗体)-based cell-cell adhesion.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 (MLLT4) interaction partners

  1. Results indicate that afadin is required for the maintenance of the radial glial scaffold for neuronal migration and that the genetic ablation of afadin leads to the formation of double cortex

  2. Here, the first crystal structure of the AFPDZ in complex with the nectin-3 (显示 PVRL3 抗体) C-terminal peptide containing the class II motif is reported.

  3. Afadin plays a role in the restricted localization of Paneth cells at the base of the crypt by maintaining their adhesion to adjacent crypt cells and inhibiting their movement toward the top of villi.

  4. S-afadin-specific C-terminal inserts may be involved in its preference of binding to nectin-3 (显示 PVRL3 抗体) and raise the possibility that there are proteins other than nectins that more preferentially bind s-afadin than l-afadin.

  5. A remarkable function of afadin was revealed, it was able to enhance cytokine expression through Rap1 activation in keratinocytes during inflammation.

  6. Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons.

  7. This study showed that the adherens junction proteins afadin and CDH2 (显示 CDH2 抗体) are critical for the control of cell proliferation in the dorsal telencephalon and for the formation of its normal laminar structure. Inactivation.

  8. Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain.

  9. Results indicate that PLEKHA7 (显示 PLEKHA7 抗体) plays a cooperative role with nectin (显示 PVRL1 抗体) and afadin in the proper formation of Adherens junction (AJ) in epithelial cell.

  10. Afadin acts upstream of the Par (显示 AFG3L2 抗体) complex to regulate the integration and/or coalescence of membrane microdomains, establishing apical-basal polarity and lumen formation/elongation during kidney tubulogenesis.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 (MLLT4) 抗原简介

Antigen Summary

This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6\;11)(q27\;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.

Alternative names and synonyms associated with Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 (MLLT4)

  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 (MLLT4) 抗体
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 4 (mllt4) 抗体
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 (mllt4) 抗体
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 (Mllt4) 抗体
  • 5033403D15Rik 抗体
  • Af-6 抗体
  • Af6 抗体
  • Afadin 抗体
  • Gm314 抗体
  • I-afadin 抗体
  • MLLT4 抗体
  • RP3-431P23.3 抗体
  • S-afadin 抗体
  • si:ch211-278j12.1 抗体

Protein level used designations for MLLT4

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 , afadin-like , ALL1-fused gene from chromosome 6 protein , afadin , protein AF-6 , myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog , protein Af-6 , myeloid/lymphoid or mixed-lineage leukemia 4

GENE ID SPECIES
421564 Gallus gallus
463135 Pan troglodytes
496308 Xenopus laevis
558359 Danio rerio
589923 Strongylocentrotus purpuratus
693560 Macaca mulatta
100054846 Equus caballus
100177180 Ciona intestinalis
100493083 Xenopus (Silurana) tropicalis
100546394 Meleagris gallopavo
100564963 Anolis carolinensis
100592208 Nomascus leucogenys
4301 Homo sapiens
17356 Mus musculus
26955 Rattus norvegicus
431695 Canis lupus familiaris
100514741 Sus scrofa
504856 Bos taurus
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