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Significant reduction of Cx30.2 mRNA was found in islets preparations incubated for 24h in 22mM as compared with 3.3mM glucose.
The data of this stiudy provided evidence that coupling of RG A1 cells to displaced amacrine cells is mediated by Cx30.2 and that the extent of this coupling is modulated by protein kinase C (显示 PKC ELISA试剂盒).
Cx30.2 contributes to the slowdown of impulse propagation in the atrioventricular node and limits the maximum number of beats conducted from atria to ventricles
In the hippocampus, co-immunofluorescence analyses revealed beta-galactosidase (显示 GLB1 ELISA试剂盒)/Cx30.2 expression in GABAergic inhibitory interneurons such as parvalbumin (显示 PVALB ELISA试剂盒)- and somatostatin (显示 SST ELISA试剂盒)-positive basket, axo (显示 MARCH7 ELISA试剂盒)-axonic, bistratified or oriens lacunosum-moleculare cells.
Cx30.2 and Cx40 (显示 GJA5 ELISA试剂盒) act as counterparts in the AV-node and His-bundle, decreasing or increasing, respectively, electrical coupling and conduction velocity in these areas.
A distal enhancer for the connexin 30.2 (Cx30.2, also known as Gjd3) gene required for normal atrioventricular (AV) delay in mice, is necessary and sufficient to direct expression to the developing AV conduction system, which is alos dependent on Gata4 (显示 GATA4 ELISA试剂盒).
Results describe the identification of a novel human gap junction gene that encodes a protein designated HCx31.9 (connexin 31.9).
Connexin 31.9 represents a novel connexin gene that in vivo generates a protein with unique voltage gating properties.
expression patterns differ from mouse orthologs [Cx30.2; Cx40.1]
Exogenous Cx31 (显示 GJB3 ELISA试剂盒) expression induced neurite outgrowth in human neuronal cell lines, but not differentiation in primary human keratinocytes.
Cx31.9 protein, unlike its counterpart in the mouse, is not expressed in detectable quantities and is thus unlikely to contribute to the impulse generation and conduction system or the working myocardium of the human heart.
This gene is a member of the large family of connexins that are required for the formation of gap junctions. Six connexin monomers form a hemichannel, or connexon, on the cell surface. This connexon can interact with a connexon from a neighboring cell, thus forming a channel linking the cytoplasm of the 2 cells.
, gap junction alpha-11 protein
, gap junction chi-1 protein
, gap junction delta-3 protein
, gap junction membrane channel protein chi 1
, connexin 31.9