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We demonstrate that AnkB binds to Rab GTPase Activating Protein 1-Like (RabGAP1L) and recruits it to PI3P-positive organelles, where RabGAP1L inactivates Rab22A, and promotes polarized trafficking to the leading edge of migrating fibroblasts. We further determine that a5b1-integrin depends on an AnkB/RabGAP1L complex for polarized recycling
The increased incidence of pro-arrhythmogenic Ca(2 (显示 CA2 ELISA试剂盒)+) sparks and waves in AnkB (显示 ANKH ELISA试剂盒)(+/-) hearts is due to enhanced CaMKII (显示 CAMK2G ELISA试剂盒)-mediated RyR (显示 RYR1 ELISA试剂盒) phosphorylation, which is caused by higher junctional [Ca(2 (显示 CA2 ELISA试剂盒)+)] and consequent local CaMKII (显示 CAMK2G ELISA试剂盒) activation.
The identification and characterization of two functionally distinct ankyrin-B isoforms in heart provide compelling evidence that alternative splicing of the ANK2 gene regulates the fidelity of ankyrin-B interactions with proteins
Taken together, these observations reveal that AnkB (显示 ANKH ELISA试剂盒) is required for Prx (显示 PRX ELISA试剂盒) membrane anchoring and for maintenance of lens fiber cell hexagonal geometry, membrane skeleton organization, and biomechanics.
that ankyrin-B deficiency results in a metabolic syndrome that combines primary pancreatic beta cell insufficiency with peripheral insulin (显示 INS ELISA试剂盒) resistance
Functional relationships between PIK3C3 (显示 PIK3C3 ELISA试剂盒), dynactin (显示 DCTN1 ELISA试剂盒), and AnkB (显示 ANKH ELISA试剂盒) promote axonal transport of organelles and are required for normal axon length.
These findings identify an interaction between ankyrin-B and both Cav2.1 (显示 CACNA1A ELISA试剂盒) and Cav2.2 (显示 CACNA1B ELISA试剂盒) at the amino acid level that is necessary for proper Cav2.1 (显示 CACNA1A ELISA试剂盒) and Cav2.2 (显示 CACNA1B ELISA试剂盒) targeting in vivo.
Ankyrin-B protein (显示 LEPREL2 ELISA试剂盒) in heart failure: identification of a new component of metazoan cardioprotection.
AnkB (显示 ANKH ELISA试剂盒) reduction alters cardiac Na and Ca transport and enhances the coupled RyR (显示 RYR1 ELISA试剂盒) openings, resulting in more frequent Ca sparks and waves although the total SR Ca leak is unaffected.
Ankyrin-B then interacts with dynactin-4 (显示 DCTN5 ELISA试剂盒) and dystrophin (显示 DMD ELISA试剂盒), whereas dynactin-4 (显示 DCTN5 ELISA试剂盒) collaborates with dystrophin (显示 DMD ELISA试剂盒) in coordinating costamere-aligned microtubules
Report disease-causing ANK2 variant localized to the membrane-binding domain resulting in reduced ankyrin-B expression and abnormal localization in a First Nations population with a high rate of long QT syndrome.
VariousANK2mutations are associated with a wide range of phenotypes, including aLQTS, especially with ventricular fibrillation, representing "ankyrin-B" syndrome.
Rare Variants in ANK2 Associated With Various Inherited Arrhythmia Syndromes.
the structures of ANK (显示 ANK1 ELISA试剂盒) repeats in complex with an inhibitory segment from the C-terminal regulatory domain and with a sodium channel Nav1.2 (显示 SCN2A ELISA试剂盒) peptide, are reported.
Gankyrin (显示 PSMD10 ELISA试剂盒) plays an essential role in estrogen-driven and GPR30 (显示 GPER ELISA试剂盒)-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K (显示 PIK3CA ELISA试剂盒)/AKT (显示 AKT1 ELISA试剂盒) signaling pathway.
ankyrin-B linker suppresses activity of the ANK (显示 ANK1 ELISA试剂盒) repeat domain through an intramolecular interaction, likely with a groove on the surface of the ANK (显示 ANK1 ELISA试剂盒) repeat solenoid, thereby regulating the affinities between ankyrin-B and its binding partners
Residues 63-73 of cdB3 is also essential for ankyrin binding.
Reduced ankyrin-B expression or mutations in ankyrin 2 are associated with atrial fibrillation.
This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats\; a central region with a highly conserved spectrin binding domain\; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described.
ankyrin 2, neuronal
, ankyrin repeat and zinc finger domain containing protein 1
, brain ankyrin
, ankyrin B
, ankyrin, brain
, ankyrin-2, nonerythrocytic
, non-erythroid ankyrin
, ankyrin 2, brain
, ankyrin 3, epithelial