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抗Rat (Rattus) TFAP2A 抗体:
抗Human TFAP2A 抗体:
抗Mouse (Murine) TFAP2A 抗体:
Mouse (Murine) Polyclonal TFAP2A Primary Antibody for WB - ABIN1945094
Moser, Pscherer, Bauer, Imhof, Seegers, Kerscher, Buettner: The complete murine cDNA sequence of the transcription factor AP-2. in Nucleic acids research 1993
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Human Polyclonal TFAP2A Primary Antibody for WB - ABIN3434032
Mitchell, Abdelrahim, Weng, Stafford, Safe, Bar-Eli, Liu: Regulation of KiSS-1 metastasis suppressor gene expression in breast cancer cells by direct interaction of transcription factors activator protein-2alpha and specificity protein-1. in The Journal of biological chemistry 2006
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Human Polyclonal TFAP2A Primary Antibody for WB - ABIN1882156
Semenza: Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1. in The Biochemical journal 2007
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Chicken Monoclonal TFAP2A Primary Antibody for ICC, IF - ABIN261468
Milgrom-Hoffman, Michailovici, Ferrara, Zelzer, Tzahor: Endothelial cells regulate neural crest and second heart field morphogenesis. in Biology open 2014
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AP2a initiates neural border patterning and is sufficient to elicit a neural border-like pattern in neuralized (显示 NEURL 抗体) ectoderm.
Genetic interaction between tfap2a and mitfa suggest that the factors en (显示 MITF 抗体)coded by these genes regulate shared targets in melanocytes, possibly within single or converging pathways.
these data support a model in which Tfap2a, acting through Bmp7a (显示 BMP7 抗体), modulates Fgf and Notch (显示 NOTCH1 抗体) signaling to control the duration, amount and speed of SAG (显示 SAG 抗体) neural development.
Prdm1a (显示 PRDM1 抗体) directly binds and activates a tfap2a enhancer at the NPB (显示 NPB 抗体)
Low Bmp activates expression of the transcription factor Tfap2a as part of a gene regulatory network that coordinates development of neural crest, preplacodal ectoderm and individual placodes in zebrafish.
tfap2a and foxd3 (显示 FOXD3 抗体) are expressed during gastrulation prior to neural crest induction in distinct, complementary, domains; tfap2a is expressed in the ventral non-neural ectoderm and foxd3 (显示 FOXD3 抗体) in the dorsal mesendoderm and ectoderm
These results reveal that mutations in TFAP2A are associated with a wide range of eye phenotypes and that hypomorphic tfap2a mutations can increase the risk of developmental defects arising from mutations at other loci.
These findings reveal that Tfap2 activity, mediated redundantly by Tfap2a and Tfap2e (显示 TFAP2E 抗体), promotes melanophore differentiation in parallel with Mitf (显示 MITF 抗体) by an effector other than Kit.
Results demonstrate that tfap2a is required for early steps in neural crest development and for the survival of a subset of neural crest derivatives.
data show that hindbrain noradrenergic neurons of the locus coeruleus and the posterior groups both require Tfap2a to establish their noradrenergic identity
Ap-2alpha regulates multiple steps of melanophore development, and is required for development of other neuronal and non-neuronal neural crest derivatives.
We identified miR (显示 MLXIP 抗体)-1254 as a negative regulator inhibiting HO-1 (显示 HMOX1 抗体) translation by directly targeting HO-1 (显示 HMOX1 抗体) 3'UTR (显示 UTS2R 抗体) via its seed region, and suppressing HO-1 (显示 HMOX1 抗体) transcription via non-seed region-dependent inhibition of transcriptional factor AP-2 alpha (TFAP2A), a transcriptional activator of HO-1 (显示 HMOX1 抗体).
dimerization-defective mutant of Nef failed to interact with either CD4 (显示 CD4 抗体) or AP-2 (显示 GTF3A 抗体) in the BiFC assay, indicating that Nef quaternary structure is required for CD4 (显示 CD4 抗体) and AP-2 (显示 GTF3A 抗体) recruitment as well as CD4 (显示 CD4 抗体) down-regulation
Data show that TFAP2A binds many of the same regulatory elements as MITF (显示 MITF 抗体) in melanocytes.
the atrial fibrillation (AF)-associated SNP rs2595104 altered PITX2c (显示 PITX2 抗体) expression via interaction with TFAP2a; such a pathway could ultimately contribute to AF susceptibility at the PITX2 (显示 PITX2 抗体) locus associated with AF
AP-2a is an important transcription factor of DEK (显示 DEK 抗体) expression, which is correlated with the methylation level of the DEK (显示 DEK 抗体) core promoter in hepatocellular carcinoma .
AP-2alpha expression has a role in human hepatocellular cancer by regulating signaling to affect cell growth and migration
Hepatitis B virus X protein is able to elevate the expression of SPHK1 (显示 SPHK1 抗体) in hepatoma cells by upregulating transcription factor AP2 alpha.
Results indicate that AP-2alpha activates COX-2 (显示 COX2 抗体) expression to promote NPC (显示 NPC1 抗体) growth.
The AP-2alpha transcription factor may play an important role in suppressing glioma progression.
TFAP2A might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC.
Study systematically examined the expression profile of AP-2 family in the developing mouse and chick spinal cord and found that AP-2alpha and AP-2beta (显示 TFAP2B 抗体) are specifically expressed in post-mitotic dorsal interneurons. Subsequent functional assessment in chick embryos demonstrated that AP-2alpha and AP-2beta (显示 TFAP2B 抗体) have distinct functions in dorsal interneuron specification and differentiation.
MEX3C (显示 MEX3C 抗体) associates with the endolysosomal compartment through an endocytosis-like process. siRNA-mediated inhibition of the MEX3C (显示 MEX3C 抗体) or AP-2 complex (显示 AP2B1 抗体) substantially decreased exosomal but not cellular microRNA miR (显示 MLXIP 抗体)-451a expression
High AP-2 alpha phosphorylation is associated with abdominal aortic aneurysm.
overexpression of Dnmt3a (显示 DNMT3A 抗体) partially rescued the impairment of adipogenesis induced by AP2alpha knockdown.
TFAP2A is a conserved component of the core network that regulates EMT (显示 ITK 抗体), acting as a repressor of many genes, including ZEB2 (显示 ZEB2 抗体).
The AP-2beta (显示 TFAP2B 抗体) transcription factor is an important effector of PITX2 (显示 PITX2 抗体) function during corneal development, required for differentiation of corneal endothelium and establishment of angiogenic privilege.
the regulation of synaptic-vesicle (SV) recycling via early endosomes by the interdependent regulation of AP-2-mediated endocytosis and AP-1 (显示 JUN 抗体)/sigma1B (显示 AP1S2 抗体)-mediated SV reformation, is reported.
By gain-of function and loss-of-function approaches, ap2a and 2b were identified to be the major downstream targets of Ptf1a (显示 PTF1A 抗体) to specify the amacrine cell fate.
Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 (显示 FGF8 抗体) gene dosage
The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
, transcription factor AP-2 alpha
, AP-2 transcription factor
, transcription factor AP-2-alpha
, transcription factor AP-2
, Transcription factor AP-2 alpha
, adipocyte lipid-binding protein
, adipocyte-type fatty acid-binding protein
, fatty acid-binding protein 4
, fatty acid-binding protein, adipocyte
, activating enhancer-binding protein 2 alpha
, activating enhancer-binding protein 2-alpha
, activator protein 2
, mont blanc
, AP-2 alpha
, Ap-2 (a)