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Rat (Rattus) NOX4 ELISA Kit for Sandwich ELISA - ABIN431602
El-Naga: Apocynin protects against ethanol-induced gastric ulcer in rats by attenuating the upregulation of NADPH oxidases 1 and 4. in Chemico-biological interactions 2015
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Human NOX4 ELISA Kit for Sandwich ELISA - ABIN417447
Vital, Castro, Ittmann: Oxidative stress promotes benign prostatic hyperplasia. in The Prostate 2016
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This study also showed that UCH-L1 (显示 UCHL1 ELISA试剂盒) promotes angiogenesis of HUVECs, as well as invasion in cancer cells, by up-regulating ROS (显示 ROS1 ELISA试剂盒) by deubiquitination of NOX4, suggesting that UCH-L1 (显示 UCHL1 ELISA试剂盒) plays a key role in angiogenesis of HUVECS by regulating ROS (显示 ROS1 ELISA试剂盒) levels by deubiquitination of NOX4.
The results reveal that NOX4 promotes glycolysis, contributing to non-small cell lung cancer cells growth, and supports glutaminolysis for oxidative resistance.
Metformin attenuates idiopathic lung fibrosis development via suppression of myofibroblast NOX4 expression.
Letter: airway smooth muscle cell NOX4 expression is increased in vivo and in vitro in COPD (显示 ARCN1 ELISA试剂盒).
TIS21 (显示 BTG2 ELISA试剂盒) attenuated Doxorubicin-induced cancer cell senescence by inhibiting linear actin nucleation via Nox4-ROS (显示 ROS1 ELISA试剂盒)-ABI2-DRF (显示 MPO ELISA试剂盒) signal cascade
These results are consistent with the hypothesis that antioxidants or NOX1 (显示 NOX1 ELISA试剂盒)/4 inhibition may be useful in blocking profibrotic effects of TGFbeta (显示 TGFB1 ELISA试剂盒) on dermal and gingival fibroblasts and warrant consideration for further development as potential antifibrotic agents
These data suggested that t-BHP induced both apoptosis and necroptosis in endothelial cells which was mediated by ROS (显示 ROS1 ELISA试剂盒) and p38MAPK (显示 MAPK14 ELISA试剂盒). ROS (显示 ROS1 ELISA试剂盒) derived from NADPH oxidase (显示 NOX1 ELISA试剂盒) and mitochondria contributed to t-BHPL and t-BHPH-induced apoptosis and necroptosis, respectively
Brd4 (显示 BRD4 ELISA试剂盒) inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-beta (显示 TGFB1 ELISA试剂盒)-mediated Nox4 expression.
We demonstrated that rapid deletion of p22phox (显示 CYBA ELISA试剂盒) is possible and that the activity of Nox1 (显示 NOX1 ELISA试剂盒) and Nox4 but not Nox5 (显示 NOX5 ELISA试剂盒) exclusively depends on p22phox (显示 CYBA ELISA试剂盒).
These processes are mediated upstream by the reactive oxygen species (ROS (显示 ROS1 ELISA试剂盒))-producing enzyme Nox4.
NOX4 actively regulates smooth muscle cells (SMC (显示 DYM ELISA试剂盒)) pathophysiological responses in diabetic Apoe (显示 APOE ELISA试剂盒)(-/-) mice and in primary mouse SMCs through the activities of PDGF (显示 PDGFA ELISA试剂盒) and NOX1 (显示 NOX1 ELISA试剂盒).
we used the Ang II (显示 AGT ELISA试剂盒) infused hph-1 (显示 EGLN2 ELISA试剂盒) mice to examine the roles of NOX isoforms in the development of AAA (显示 AAAS ELISA试剂盒). We generated double mutants of hph-1 (显示 EGLN2 ELISA试剂盒)-NOX1 (显示 NOX1 ELISA试剂盒), hph-1 (显示 EGLN2 ELISA试剂盒)-NOX2 (显示 CYBB ELISA试剂盒), hph-1 (显示 EGLN2 ELISA试剂盒)-p47phox, and hph-1 (显示 EGLN2 ELISA试剂盒)-NOX4
The major reactive oxygen species (ROS (显示 ROS1 ELISA试剂盒)) source in brain, NADPH oxidase (显示 NOX1 ELISA试剂盒) subunit 4 increased in hypoxia but not in hyperoxia, whereas neither affected nuclear factor (erythroid-derived 2)-like 2 (显示 NFE2L2 ELISA试剂盒), a transcription factor that regulates the expression of antioxidant proteins
Nox4 has no influence on lifespan of healthy mice.
MFA has a protective effect on alcohol-induced liver injury, which may be related to its antioxidant,anti-inflammatory,lipid-eliminating properties and its ability to regulate the NOX4/ROS (显示 ROS1 ELISA试剂盒)-MAPK (显示 MAPK1 ELISA试剂盒) signalling pathway.
Nox2 (显示 CYBB ELISA试剂盒)- and Nox4-derived reactive oxygen species contribute to stem cell pluripotency maintenance and self-renewal.
FYN (显示 FYN ELISA试剂盒) is activated by oxidative stress and serves as a negative feedback regulator of NOX4 in cardiomyocytes during cardiac remodeling
NOX4-derived reactive oxygen species in general, and possibly superoxide in particular, are involved in flow-stimulated inner medullary collecting duct ET-1 (显示 EDN1 ELISA试剂盒) production.
Peroxide derived from superoxide generated by Nox4 appears to maintain a basal relaxation in bovine pulmonary arteries under normoxic conditions, which is removed under hypoxia leading to hypoxic pulmonary vasoconstriction.
MRTF down-regulation/inhibition suppresses TGFbeta (显示 TGFB1 ELISA试剂盒)/contact disruption-provoked Nox4 protein and mRNA expression, Nox4 promoter activation, and reactive oxygen species production.
Nox4 NADPH oxidase (显示 NOX1 ELISA试剂盒) mediates oxidative stress and apoptosis caused by TNF-alpha (显示 TNF ELISA试剂盒) in cerebral vascular endothelial cells.
Nox4 NADPH oxidase (显示 NOX1 ELISA试剂盒)-derived reactive oxygen species also initiate a cell survival mechanism by increasing production of carbon monoxide by constitutive heme oxygenase-2 (显示 HMOX2 ELISA试剂盒).
proteasome inhibition completely prevented endoplasmic reticulum stress-induced increase in NADPH oxidase (显示 NOX1 ELISA试剂盒) activity, as well as increases in Nox4 isoform and protein disulfide isomerase (显示 P4HB ELISA试剂盒) mRNA expression
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
, kidney superoxide-producing NADPH oxidase
, renal NAD(P)H-oxidase
, superoxide-generating NADPH oxidase 4
, NADPH oxidase 4
, predicted NADPH oxidase-4