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RanBPM (显示 RANBP9 ELISA试剂盒) acts as a negative regulator of BLT2 and IL8 (显示 IL8 ELISA试剂盒), thus attenuating the invasiveness of aggressive breast cancer cells
BLT2 inhibition induces apoptosis, inhibits proliferation, colony formation and self-renewal capacity of CD34 (显示 CD34 ELISA试剂盒)(+) cells from tyrosine kinase (显示 TXK ELISA试剂盒) inhibitor - resistant blast phase-chronic myeloid leukemia (显示 BCL11A ELISA试剂盒) patients.
Data show that signal transducer and activator of transcription-3 (STAT-3 (显示 STAT3 ELISA试剂盒)) activation occurs downstream of leukotriene B4 receptor-2 (BLT2) and mediates cisplatin resistance in SK-OV-3 cells.
Authors demonstrated that MyD88 (显示 MYD88 ELISA试剂盒) lies upstream of BLT2 in LPS (显示 IRF6 ELISA试剂盒)-potentiated invasiveness and that this 'MyD88 (显示 MYD88 ELISA试剂盒)-BLT2' cascade mediates activation of NF-kappaB (显示 NFKB1 ELISA试剂盒) and the synthesis of IL-6 (显示 IL6 ELISA试剂盒) and IL-8 (显示 IL8 ELISA试剂盒) critical for the invasiveness and aggression of breast cancer cells.
BLT1 and BLT2 are therefore potential targets for the development of novel drugs.
searched BLT2 downstream components and identified reactive oxygen species and nuclear factor kappaB as critical components that contribute to epithelial-mesenchymal transition in mammary epithelial cells
BLT2-NOX-ROS (显示 ROS1 ELISA试剂盒)-NF-kappaB (显示 NFKB1 ELISA试剂盒) cascade induction during detachment confers a novel mechanism of anoikis resistance in prostate cancer cells and potentially contributes to prostate cancer progression.
RanBPM (显示 RANBP9 PLURAL_@4829@) acts as a negative regulator of BLT2 signaling to attenuate BLT2-mediated cell motility
Findings indicate that BLT2 has a protective role in allergic airway inflammation and that diminished BLT2 expression in CD4 (显示 CD4 ELISA试剂盒)(+) T cells may contribute to the pathophysiology of asthma.
BLT2 is a novel therapeutic target that sensitises drug-resistant breast cancer cells to paclitaxel.
findings suggest that a leukotriene B4 receptor-2-linked cascade plays a pivotal role in LPS/TLR4 (显示 TLR4 ELISA试剂盒) signaling for IL-13 (显示 IL13 ELISA试剂盒) synthesis in mast cells, thereby potentially exacerbating allergic response.
This study demonstrates that LTB4 (显示 PTGR1 ELISA试剂盒) promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL
BLT2 expression in mast cells is essential for the production of VEGF in OVA-induced allergic asthma.
These results show that 12-HHT (显示 ACVRL1 ELISA试剂盒)/BLT2 enhances epithelial barrier function by increasing CLDN4 (显示 CLDN4 ELISA试剂盒) expression via the Galphai protein-p38 MAPK (显示 MAPK14 ELISA试剂盒) pathway.
Data indicate that leukotriene B4 receptor 2 protein BLT2-deficient mice exhibited impaired re-epithelialization and delayed wound closure after skin punching.
Leukotriene B4 receptor-2 promotes invasiveness and metastasis of ovarian cancer cells through signal transducer and activator of transcription 3 (STAT3 (显示 STAT3 ELISA试剂盒))-dependent up-regulation of matrix metalloproteinase 2 (显示 MMP2 ELISA试剂盒)
Selective inhibition of the BLT2 receptor in mice reduces the release of vascular reactive oxygen species and improves endothelial function in mice
Results suggest a direct anti-inflammatory role of BLT2 that is distinct from the proinflammatory roles of BLT1.
our results suggest that the BLT2-Nox1 (显示 NOX1 ELISA试剂盒)-reactive oxygen species cascade is a previously unsuspected mediatory signaling mechanism to Th2 cytokine production in Ag-stimulated BMMCs
mouse homolog is a chemoattractant for myeloid leukocytes
leukotriene B4 receptor 2
, LTB4 receptor JULF2
, leukotriene B4 receptor BLT2
, seven transmembrane receptor BLTR2
, LTB4-R 2