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RACK1 emerges as an important marker of malignancy which may contribute to progress in the diagnosis of melanomas in both human and veterinary medicine.[RACK1]
Leads to the enhanced and previously un-described interaction of RACK1 and TCTP (显示 TPT1 ELISA试剂盒).
urther investigation indicated that p205 may disturb the formation of Runx2 (显示 RUNX2 ELISA试剂盒)/Ids (显示 IDS ELISA试剂盒) complex and free more Runx2 (显示 RUNX2 ELISA试剂盒) to induce the differentiation process. Taken together, our findings demonstrated for the first time that p205 functions as an activator in osteoblast differentiation.
RACK1 competes with Rab40C for binding to the ANKR2 domain of Varp (显示 ANKRD27 ELISA试剂盒) and regulates dendrite outgrowth through stabilization of Varp (显示 ANKRD27 ELISA试剂盒) in mouse melanocytes
Data show that receptor for activated C-kinase 1 (RACK1) and vascular endothelial growth factor (VEGF) expression is up-regulated after choroidal neovascularization (CNV) formation.
RACK1 is a novel factor required for adipocyte differentiation.
deficit of RACK1 in hippocampus impairs the ability of learning and memory in mice via up regulating autophagy
RACK1 plays an important role in the maintenance of morphine conditioned place preference, likely via activation of ERK (显示 EPHB2 ELISA试剂盒)-CREB (显示 CREB1 ELISA试剂盒) pathway in hippocampus.
Thr50 phosphorylation of RACK1 enhances its direct binding to Vps15, Atg14L, and Beclin 1 (显示 BECN1 ELISA试剂盒), thereby promoting the assembly of the autophagy-initiation complex.
These findings suggest that RACK1 specifies the RANKL (显示 TNFSF11 ELISA试剂盒)-stimulated activation of p38 MAPK (显示 MAPK14 ELISA试剂盒) by facilitating the association of MKK6 (显示 MAP2K6 ELISA试剂盒) with TAK1 (显示 NR2C2 ELISA试剂盒)
RACK1 stimulates the translation of collagen 1alpha 1, snail (显示 SNAI1 ELISA试剂盒) and cyclin E1 (显示 CCNE1 ELISA试剂盒) in hepatic stellate cells.
The upregulation of RACK1 can promote the proliferation and invasion of nasopharyngeal carcinoma by regulating the PI3K (显示 PIK3CA ELISA试剂盒)/Akt (显示 AKT1 ELISA试剂盒)/FAK (显示 PTK2 ELISA试剂盒) signal pathway.
It has been found that the adaptor protein receptor for activated PKC kinase (RACK1) formed a complex with FGFR1 and PKM2, and activated the FGFR1/PKM2 signaling. The study shows that RACK1 forms a complex with FGFR1 and PKM2, and stimulates the growth and migration of squamous lung cancer cells.
GNB2L1 and its O-GlcNAcylation regulated metastasis via modulating the translation of epithelial-mesenchymal transition-related proteins in the chemoresistance of gastric cancer.
Our findings suggest that RACK1 promotes proliferation and radioresistance in ESCC cells by activating the AKT (显示 AKT1 ELISA试剂盒) pathway, upregulating Bcl-2 (显示 BCL2 ELISA试剂盒) expression and downregulating protein levels of Bim (显示 BCL2L11 ELISA试剂盒). Our study fills in gaps in the field of RACK1 and radiation resistance and may provide new possibilities for improving strategies of radiotherapy in esophageal cancer.
ZNF598 (显示 ZNF598 ELISA试剂盒), RACK1, and 40S regulatory ubiquitylation plays a pivotal role in mammalian ribosome-associated quality control pathways.
beta-actin (显示 ACTB ELISA试剂盒) is a new RACK1 binding partner and that the RACK1 and beta-actin (显示 ACTB ELISA试剂盒) association participate in the cAMP-dependent regulation of BDNF (显示 BDNF ELISA试剂盒) transcription
RACK1 is required for efficient processing of the 18S rRNA 3'-end, which might be related to its role in translation initiation.
the O-GlcNAcylation on GNB2L1 reversed its inhibition on gastric tumour metastasis via promoting its degradation.
RACK1 could play an important role in the tumorigenesis of pancreatic ductal adenocarcinoma (PDAC) and serve as a potential therapeutical target in PDAC treatment.
RACK1 could be a relevant target of endocrine disrupting chemicals, responding in opposite ways to androgen receptor (显示 AR ELISA试剂盒) agonists/antagonists, representing a bridge between the endocrine system and the innate immune system.
Rack1 has a dominant-negative effect on Vangl2 (显示 VANGL2 ELISA试剂盒) localization and gastrulation.
These results suggest that PKCepsilon (显示 PRKCE ELISA试剂盒) signaling in the basal airway cell may involve RACK1; however, PKCepsilon (显示 PRKCE ELISA试剂盒) regulation in ciliated cells uses RACK1-independent pathways.
RACK-1 controls the biogenesis of a subset of miRNAs, including let-7, and in this way plays a role in the heterochronic gene pathway during C. elegans development.
RACK1 can contribute to the recruitment of miRISC to the site of translation, and support a post-initiation mode of miRNA-mediated gene repression.
show that depletion of Caenorhabditis elegans RACK-1, which leads to short astral microtubules during prometaphase, specifically affects maintenance of cortical PAR (显示 AFG3L2 ELISA试剂盒) domains and Dynamin localization
These studies pinpoint RACK-1 as a component of a novel signaling pathway involving Rac (显示 AKT1 ELISA试剂盒) GTPases and UNC-115/abLIM (显示 ABLIM1 ELISA试剂盒).
suggest a mechanism by which RACK-1 directs the dynactin (显示 DCTN1 ELISA试剂盒)-dependent redistribution of recycling endosomes during the cell cycle
may act as a receptor for activated protein kinase C
guanine nucleotide binding protein, beta 2, related sequence 1
, guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
, G-beta-like protein
, guanine nucleotide-binding protein beta subunit
, activated protein kinase C receptor
, guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 sequence 1
, guanine nucleotide binding protein related
, guanine nucleotide binding protein, beta-2, related sequence 1
, guanine nucleotide-binding protein subunit beta-2-like 1
, receptor for activated C kinase
, receptor of activated protein kinase C 1
, guanine nucleotide binding protein (G protein) beta polypeptide 2-like 1
, guanine nucleotide binding protein, beta polypeptide 2-like 1
, protein kinase C receptor
, receptor for activated protein kinase C
, cell proliferation-inducing gene 21 protein
, guanine nucleotide-binding protein subunit beta-like protein 12.3
, human lung cancer oncogene 7 protein
, lung cancer oncogene 7
, proliferation-inducing gene 21
, protein homologous to chicken B complex protein, guanine nucleotide binding
, receptor for activated C kinase 1
, receptor of activated protein kinase C
, Guanine nucleotide-binding protein beta subunit2-like 1
, MHC B complex protein 12.3
, guanine nucleotide binding 12.3
, guanine nucleotide-binding protein beta subunit 2-like 1
, G-beta like protein