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this study shows that Galphai3-deficient neutrophils display reduced transmigration but normal arrest
GIV (显示 CCDC88A ELISA试剂盒) and its substrate Galphai3 are recruited to active integrin complexes
Data show that disrupting resistance to inhibitors of cholinesterase 8A (Ric-8A (显示 RIC8A ELISA试剂盒)) expression in hematopoietic cells results in a loss of GTP-binding protein (显示 DRG1 ELISA试剂盒) alpha subunits Galphai2 (显示 GNAI2 ELISA试剂盒), Galphai3, and Galphaq (显示 GNAQ ELISA试剂盒).
Data show that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo.
Myocardial ischemia promptly regulated cardiac mRNA and with a slight delay protein levels of both Galphai2 (显示 GNAI2 ELISA试剂盒) and Galphai3, indicating important roles for both Galphai isoforms.
The absence of Galphai2 (显示 GNAI2 ELISA试剂盒) and Galphai3 in B cells profoundly disturbs the architecture of lymphoid organs with loss of B cell compartments in the spleen, thymus, lymph nodes, and gastrointestinal tract.
RGS19 (显示 RGS19 ELISA试剂盒) and its partner Galpha (显示 SUCLG1 ELISA试剂盒)-inhibiting activity polypeptide 3 (显示 CYP ELISA试剂盒) (GNAI3) are involved in zVAD-, but not TNF (显示 TNF ELISA试剂盒)-, induced cell death.
support for the hitherto untested model that Par3 (显示 F2RL2 ELISA试剂盒)-mInsc and Galphai3 act cooperatively to polarize LGN (显示 GPSM2 ELISA试剂盒) and promote perpendicular divisions
level of basal autophagy, autophagic induction, autophagic flux, autophagic degradation and the anti-autophagic action in macrophages that lacked Galphai3, AGS3 (显示 GPSM1 ELISA试剂盒), or RGS19 (显示 RGS19 ELISA试剂盒); or had been treated with pertussis toxin, were similar to controls
A constitutively active Galphai3 protein corrects the abnormal retinal pigment epithelium phenotype of Oa1 (显示 GPR143 ELISA试剂盒)-/- mice.
GNAI3 is identified a second gene possibly responsible for X-linked ocular albinism.
These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2 (显示 GNAI2 ELISA试剂盒), and Galphai3, with no evidence for functional coupling to Galphagust.
Data show that auriculo-condylar syndrome (ACS (显示 PLA2G15 ELISA试剂盒))-associated mutations in G protein subunit alpha i3 (GNAI3) produce dominant-negative Galpha (显示 SUCLG1 ELISA试剂盒)(i3) mutant proteins that couple to endothelin type A receptor (ET(A (显示 EDNRA ELISA试剂盒))R).
In postmortem human prefrontal cortex, adenosine A1 receptor (显示 ADORA1 ELISA试剂盒) is coupled preferentially, if not exclusively, to Galphai-3.
transcriptional upregulation of Girdin (显示 CCDC88A ELISA试剂盒) expression and Girdin (显示 CCDC88A ELISA试剂盒)-Galphai3 signaling play crucial roles in regulating epithelial apicobasal polarity through the PAR (显示 JTB ELISA试剂盒) complex.
We demonstrate that the GNAI3 variant is the likely cause of auriculocondylar syndrome in the original ACS1 family.
Both SH2 and GEF domains of GIV (显示 CCDC88A ELISA试剂盒) are required for the formation of a ligand-activated ternary complex between GIV (显示 CCDC88A ELISA试剂盒), Galphai3, and EGFR (显示 EGFR ELISA试剂盒).
Low GNAI3 expression is associated with hepatocellular carcinoma.
Data indicate that dynein- and astral microtubule-mediated transport of Galphai/LGN (显示 GPSM2 ELISA试剂盒)/nuclear mitotic apparatus (NuMA (显示 NUMA1 ELISA试剂盒)) complex from cell cortex to spindle poles.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway.
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
, guanine nucleotide-binding protein G(k) subunit alpha-like
, g(i) alpha-3
, guanine nucleotide binding protein, alpha inhibiting 3
, guanine nucleotide-binding protein G(k) subunit alpha
, Gi3 protein alpha-subunit
, guanine nucleotide binding protein alpha inhibiting 3
, G protein alpha subunit
, Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3
, guanine nucleotide binding protein (G protein), alpha inhibiting 3
, alpha-subunit of G-protein, type G-alpha-i-3