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Early diagnosis of infectious disease is accomplished by measuring pathogen-specific IgM antibodies, which are the first line of humoral immune-defence after the infection occurs. The determination of the specific IgM antibodies may be hampered by the presence of IgG antibodies, competing with the IgM antibodies for antigen binding sites which can result in false negative IgM results. Also the presence of rheumatoid factors can cause false positive IgM results. The Rheumatoid Factor Removal Solution is designed to remove human IgG and Rheumafactors by immunoprecipitation with polyclonal anti-human IgG antibodies.