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Polymorphism of HCN1 is associated with breast cancer.
Study presents cryo-electron microscopy structures of the human HCN1 channel in the absence and presence of cAMP at 3.5 A resolution. HCN channels contain a K(+) channel (显示 KCNC4 ELISA试剂盒) selectivity filter-forming sequence from which the amino acids create a unique structure that explains Na(+) and K(+) permeability.
A new mode of regulating HCN1 trafficking: through the use of a di-arginine ER retention signal that monitors processing of the channel in the early secretory pathway.
de novo HCN1 point mutations cause a recognizable early-onset epileptic encephalopathy in humans
acute abrogation of HCN1-FLNa (显示 FLNA ELISA试剂盒) interaction in neurons, with the use of decoy peptides that mimic the FLNa (显示 FLNA ELISA试剂盒)-binding domain of HCN1, abolishes the punctate distribution of HCN1 channels in neuronal cell bodies
Studies suggest that HCN1 channels may be therapeutic targets for treatment of depressive disorders.
Wild-type presynaptic HCN1 channel function is persistently decreased following seizures.
HCN1 channels make an important contribution to the maintenance of spontaneous burst activity in embryonic cortical neuron cultures.
Hyperpolarization-activated currents are smaller and slower, input resistances are higher, and membrane time constants are longer in HCN1-deficient than in HCN1-expressing neurons of the ventral cochlear nucleus.
Genetic analysis in 48 Sudden unexpected death in epilepsy cases identified six novel and three previously reported nonsynonymous (amino acid changing) variants in HCN1 , HCN2 (显示 HCN2 ELISA试剂盒), HCN3 (显示 HCN3 ELISA试剂盒) and HCN4 (显示 HCN4 ELISA试剂盒).
HCN channels play a critical role in the separation of overlapping movement responses and allow for successful reaching behaviours. These data provide a novel mechanism for the encoding of multiple movement responses within shared networks of motor cortex. This mechanism supports a viewpoint of primary motor cortex as a site of dynamic integration for behavioural output
The study thus identifies novel candidate QTGs HCN1 that may contribute to variation in emotional learning in mice.
Data show that prostaglandin E2 receptor EP3 subtype (EP3 (显示 PTGER3 ELISA试剂盒)) was expressed in the interstitial cells of Cajal (ICCs) of the bladder and activated hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
Data show that KCNJ15 inward rectifier potassium channel and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel currents are changed in Trisomic neuron.
We investigated the effects of an additional genetic deletion of HCN1 on the function and survival of photoreceptors in a mouse model of CNGB1-linked retinitis pigmentosa (RP).
in the absence of HCN1-mediated feedback, the amplitude of rod signals remains at high levels for a prolonged period of time, leading to saturation of the retinal pathways.
These results demonstrate that the CB1R (显示 CNR1 ELISA试剂盒)-Ih pathway in the hippocampus is obligatory for the action of cannabinoids on long-term potentiation and spatial memory formation.
Resilience to tinnitus is developed in mice that show a re-emergence of KCNQ2/3 channel activity and a reduction in HCN channel activity.
HCN1, HCN2 (显示 HCN2 ELISA试剂盒), and HCN4 (显示 HCN3 ELISA试剂盒) subunits may have distinct physiological roles in the developing hippocampus.
Forebrain HCN1 channels contribute to hypnotic and amnestic effects of volatile anesthetics, but do not contribute to immobilizing actions.
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes.
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
, brain cyclic nucleotide gated channel 1
, brain cyclic nucleotide-gated channel 1
, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
, hyperpolarization-activated cyclic nucleotide-gated channel 1
, hyperpolarization-activated cation channel 2