anti-大鼠 XIAP 抗体 for Immunohistochemistry (Paraffin-embedded Sections)

Recommended XIAP Antibody (supplied by: Log in to see )

抗原
X-Linked Inhibitor of Apoptosis (XIAP) 抗体
  • BIRC4
  • api3
  • birc4
  • ilp1
  • miha
  • xlp2
  • xxiap
  • API3
  • IAP-3
  • ILP1
  • MIHA
  • XLP2
  • hIAP-3
  • hIAP3
  • 1110015C02Rik
  • Aipa
  • Api3
  • Birc4
  • IAP3
  • ILP-1
  • mXIAP
  • riap3
  • X-linked inhibitor of apoptosis
  • XIAP
  • xiap
  • Xiap
抗原表位
AA 230-280
21
18
14
9
9
8
8
6
5
5
5
4
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
适用
人, 小鼠, 大鼠
185
93
61
7
5
5
2
宿主

159
26
1
克隆类型
多克隆
标记
This XIAP antibody is un-conjugated
6
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
应用范围
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
162
72
53
45
31
23
12
12
9
9
3
3
2
1
1
选项
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Available images

产品编号 ABIN674364
$ 307.45
加上运输费 $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN272094 IHC (p) WB Rabbit Log in to see Polyclonal
1 ABIN127043 IHC (p) IP WB Rabbit Log in to see Polyclonal
1 ABIN3044425 IHC (p) WB Rabbit IgG AA 14-34, N-Term Log in to see Polyclonal 3
1 ABIN2888718 IHC (p) ELISA WB Rabbit IgG AA 53-102 Log in to see Polyclonal
1 ABIN957244 IHC (fro) IHC (p) IP WB Rabbit AA 163-230 Log in to see Polyclonal
1 ABIN957246 IHC (fro) IHC (p) IP WB Rabbit AA 163-230 Log in to see Polyclonal
1 ABIN957245 IHC (fro) IHC (p) IP WB Rabbit AA 163-230 Log in to see Polyclonal
1 ABIN957247 IHC (fro) IHC (p) IP WB Rabbit AA 163-230 Log in to see Polyclonal
1 ABIN674373 IHC (p) WB HRP Rabbit IgG AA 230-280 Log in to see Polyclonal
1 ABIN4366393 IHC IHC (p) IP WB Rabbit BIR2 Domain Log in to see Polyclonal 2
1 ABIN674366 IHC (p) WB Biotin Rabbit IgG AA 230-280 Log in to see Polyclonal
1 ABIN2891845 IHC (p) WB Rabbit Gly81 Log in to see Polyclonal
1 ABIN3029643 IHC (p) WB Rabbit IgG N-Term Log in to see Polyclonal
1 ABIN4366390 IHC IHC (p) IP WB Rabbit BIR2 Domain Log in to see Polyclonal
1 ABIN4366392 IHC IHC (p) IP WB Rabbit BIR2 Domain Log in to see Polyclonal
1 ABIN4366388 IHC IHC (p) IP WB Rabbit BIR2 Domain Log in to see Polyclonal
1 ABIN4366387 IHC IHC (p) WB Rabbit Log in to see Polyclonal
1 ABIN4366389 IHC IHC (p) IP WB Rabbit BIR2 Domain Log in to see Polyclonal
1 ABIN4366391 IHC IHC (p) IP WB Rabbit BIR2 Domain Log in to see Polyclonal
1 ABIN537435 IHC (fro) IHC (p) IP WB Rabbit Log in to see Polyclonal

General

抗原 X-Linked Inhibitor of Apoptosis (XIAP) 抗体
抗原表位 AA 230-280
(21), (18), (14), (9), (9), (8), (8), (6), (5), (5), (5), (4), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
适用 人, 小鼠, 大鼠
(185), (93), (61), (7), (5), (5), (2)
宿主
(159), (26), (1)
克隆类型
多克隆
标记 This XIAP antibody is un-conjugated
(6), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
应用范围 Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(162), (72), (53), (45), (31), (23), (12), (12), (9), (9), (3), (3), (2), (1), (1)
Pubmed 4个引用可参考
Supplier Log in to see

XIAP抗体详情

XIAP目标详情 使用细节 贮存及处理 References for anti-XIAP antibody (ABIN674364) 图像
纯化方法 Purified by Protein A.
免疫原 KLH conjugated synthetic peptide derived from mouse XIAP
亚型 IgG

XIAP目标详情

XIAP抗体详情 使用细节 贮存及处理 References for anti-XIAP antibody (ABIN674364) 图像 回页首
抗原
别名 Xiap (XIAP Antibody 摘要)
背景

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.

Subcellular location: Cytoplasm, Nucleus

Synonyms: Aipa, Api3, IAP3, MIHA, Birc4, ILP-1, 11115C2Rik, E3 ubiquitin-protein ligase XIAP, Baculoviral IAP repeat-containing protein 4, IAP homolog A, Inhibitor of apoptosis protein 3, IAP-3, mIAP-3, mIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP, Xiap

基因ID 11798
UniProt Q60989
途径 Apoptosis, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis

使用细节

XIAP抗体详情 XIAP目标详情 贮存及处理 References for anti-XIAP antibody (ABIN674364) 图像 回页首
应用备注 WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200
限制 仅限研究用

贮存及处理

XIAP抗体详情 XIAP目标详情 使用细节 References for anti-XIAP antibody (ABIN674364) 图像 回页首
状态 Liquid
浓度 1 μg/μL
缓冲液 Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
储存条件 -20 °C
储存方法 Store at -20°C
有效期 12 months

References for anti-XIAP antibody (ABIN674364)

XIAP抗体详情 XIAP目标详情 使用细节 贮存及处理 图像 回页首
有引用在:

Sun, Liu, Zou, Lan, Sun, Wang, Zhao, Jiang, Liu: "Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer." in: Journal of bioenergetics and biomembranes, 2015

Jin, Lan, Han, Sun, Liu, Zhang, Liu, Zhang, Hu, Liu, Wang: "Smac mimetic?induced caspase?independent necroptosis requires RIP1 in breast cancer." in: Molecular medicine reports, 2015

Chen, Xie, Zhao, Wang, Bai, Yin, Jiang, Xie, Jia, Huang et al.: "Ampelopsin induces apoptosis by regulating multiple c?Myc/S?phase kinase?associated protein 2/F?box and WD repeat?containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma ..." in: Molecular medicine reports, Vol. 11, Issue 1, pp. 105-12, 2014 Method employed by authors: Western Blotting (WB) (Sample species: Human).

Chen, Bai, Zhong, Xie, Long, Yang, Wu, Jia, Wang: "Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7? and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549." in: PLoS ONE, Vol. 8, Issue 11, pp. e79201, 2013

图像

XIAP抗体详情 XIAP目标详情 使用细节 贮存及处理 References for anti-XIAP antibody (ABIN674364) 回页首
厂商提供的图像
Immunohistochemistry (IHC) image for anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 230-280) antibody (ABIN674364) Formalin-fixed and paraffin embedded human endometrial tissue labeled with Anti-XIAP/...
Immunofluorescence (Cultured Cells) (IF (cc)) image for anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 230-280) antibody (ABIN674364) Image provided by One World Lab validation program. MCF-7 cells probed with Rabbit An...
Immunofluorescence (Cultured Cells) (IF (cc)) image for anti-X-Linked Inhibitor of Apoptosis (XIAP) (AA 230-280) antibody (ABIN674364) Image provided by One World Lab validation program. A549 cells probed with Rabbit Ant...