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Human Polyclonal SET Primary Antibody for WB - ABIN4620361
von Lindern, van Baal, Wiegant, Raap, Hagemeijer, Grosveld: Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene. in Molecular and cellular biology 1992
Show all 12 Pubmed References
Data show that PP32 and SET/TAF-Ibeta proteins block HAT1-mediated H4 acetylation.
Overexpression of SET-Nup214 in HeLa cells leads to the formation of similar nuclear bodies that recruit CRM1, export cargo proteins, and certain nucleoporins and concomitantly affect nuclear protein and poly(A)(+) RNA export.
Molecular chaperone (显示 HSP90AA1 抗体) SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression.
Our findings suggested the oncogenic role of SET and the adverse prognostic value of SET overexpression in hepatocellular carcinoma (HCC (显示 FAM126A 抗体)). This alteration defines a subgroup of HCC (显示 FAM126A 抗体) patients who could benefit from SET antagonists, such as EMQA.
This review summarizes and discusses the general mechanisms of H3K4 methylation, and how the six main enzymes from the SET/MLL (显示 MLL 抗体) family (responsible for H3K4me1/me2 (显示 CELSR1 抗体)/me3 (显示 ME3 抗体)) function in hematopoiesis and in hematologic malignancies. [review]
identification of the oncoprotein SET as a major cellular factor whose binding with p53 (显示 TP53 抗体) is dependent on C-terminal domain acetylation status
Data indicate that SET protein as a direct target of microRNA miR (显示 MLXIP 抗体)-125b, and the downregulation of SET, observed during tumor migration, was affected by the overexpression of miR125b.
significance of SET/I2PP2A-mediated PP2A (显示 PPP2R4 抗体) and non-PP2A (显示 PPP2R4 抗体) pathways in polycystic ovary syndrome
Data show that downregulating proto-oncogene (显示 RAB1A 抗体) protein Akt (p-Akt (显示 AKT1 抗体)) by inhibiting PP2A (显示 PPP2R4 抗体) inhibitor SET-mediated protein phosphatase 2A (PP2A (显示 PPP2R4 抗体)) inactivation determined the pro-apoptotic effects of EMQA and paclitaxel combination treatment.
Data suggest a critical role for the I2PP2A protein (SET)-protein phosphatase-2A (PP2A (显示 PPP2R4 抗体)) signaling axis in Pten (显示 PTEN 抗体) protein (Pten (显示 PTEN 抗体)) deficient castration resistant prostate cancer (CRPC) progression.
Data suggest a critical role for the I2PP2A protein (SET)-protein phosphatase-2A (PP2A (显示 PPP2R2B 抗体)) signaling axis in Pten (显示 PTEN 抗体) protein (Pten (显示 PTEN 抗体)) deficient castration resistant prostate cancer (CRPC) progression.
The presence of full-length SET in the neuronal cytoplasm is sufficient to impair PP2A (显示 PPP2R2B 抗体) methylation and activity, leading to tau hyperphosphorylation.
SET/PP2A (显示 PPP2R2B 抗体) system regulates testosterone production in ovarian follicles in vitro.
SET played a positive role in regulating ovarian androgen biosynthesis by enhancing the transcription of steroidogenic enzymes CYP17A1 (显示 CYP17A1 抗体) and HSD3B2 (显示 HSD3B2 抗体), which maybe contribute to the hyperandrogenism in polycystic ovary syndrome
study found SET, a putative oncogene (显示 RAB1A 抗体) was significantly downregulated in a bisphenol A dose-dependent manner; from gene network analysis, SET is predicted to communicate with other genes including CYP17 (显示 CYP17A1 抗体), which is involved in biosynthesis and metabolism of sex-hormones
Our results suggest that the increased I(2)(PP2A (显示 PPP2R2B 抗体)) may trigger apoptosis by p53 (显示 TP53 抗体) upregulation, but due to simultaneous activation of Akt (显示 AKT1 抗体), the neurons are aborted from the apoptotic pathway.
SET is an important regulator of chromosome condensation (显示 RCC1 抗体)/decondensation and that disruption of the MCPH1 (显示 MCPH1 抗体)-SET interaction might be important for the pathogenesis of primary microcephaly
By a novel molecular mechanism, apolipoprotein (apo)E (显示 APOE 抗体)/peptide enhances protein phosphatase 2A (PP2A (显示 PPP2R2B 抗体)) activity within a cell by binding/forming a complex with SET, reducing the amount of SET available to inhibit PP2A (显示 PPP2R2B 抗体), signaling, and inflammatory response.
These studies indicated that the TAF (显示 TAF8 抗体)-Ialpha promoter is under the control of Sp1 (显示 SP1 抗体).(TAF (显示 TAF8 抗体)-Ialpha )
The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene.
protein phosphatase 2A inhibitor 2-like
, HLA-DR-associated protein II
, SET translocation (myeloid leukemia-associated)
, Template-Activating Factor-I, chromatin remodelling factor
, inhibitor of granzyme A-activated DNase
, inhibitor-2 of protein phosphatase-2A
, phosphatase 2A inhibitor I2PP2A
, protein SET
, protein phosphatase type 2A inhibitor
, SET translocation
, template-activating factor I
, liver regeneration-related protein LRRGR00002