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DFFB 抗体

(DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq, Jul 2008].
DFFB 抗体  (AA 1-289) DFFB 抗体  (AA 1-289) DFFB 抗体 (AA 1-289) (ABIN7193449)

DFFB 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 2E6G3 unconjugated

DFFB 抗体  (N-Term) DFFB 抗体  (N-Term) DFFB 抗体 (N-Term) (ABIN653798)

DFFB 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24419 unconjugated

DFFB 抗体  (AA 108-219) DFFB 抗体  (AA 108-219) DFFB 抗体 (AA 108-219) (ABIN7150177)

DFFB 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

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Find DFFB 抗体 for a variety of species such as anti-Human DFFB, anti-Mouse DFFB, anti-Rat DFFB. The species listed below are among those available. Click on a link to go to the corresponding products.

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Find DFFB 抗体 validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

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Popular DFFB 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, FACS
Validations
  • (4)
Cat. No. ABIN7193449
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (4)
Cat. No. ABIN653798
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7150177
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN560596
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN514957
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN541393
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ICC
Validations
  • (2)
Cat. No. ABIN541752
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ICC
Validations
  • (2)
Cat. No. ABIN541751
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN307617
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (1)
Cat. No. ABIN724085
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (1)
Cat. No. ABIN872776
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN208001
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, ICC
Validations
  • (1)
Cat. No. ABIN203319
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC
Validations
  • (1)
Cat. No. ABIN201898
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (1)
Cat. No. ABIN6139552
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our DFFB 抗体

Yoon, Park, Han, Kang, Kim, Lee, Park, Shin, Kim, Yun, Chwae: "Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns." in: Cell death & disease, Vol. 5, pp. e1494, (2014) (PubMed).

Kumar, Kant, Singh et al.: "Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: a role of reorganized glucose metabolism, cell survival regulation and macrophage ..." in: Toxicology and applied pharmacology, Vol. 273, Issue 1, pp. 196-208, (2013) (PubMed).

Nagata: "DNA degradation in development and programmed cell death." in: Annual review of immunology, Vol. 23, pp. 853-75, (2005) (PubMed).

Kanouchi, Nishizaki, Minatogawa, Toné: "Large complex formation of the inhibitor of caspase-activated DNase." in: Apoptosis : an international journal on programmed cell death, Vol. 10, Issue 3, pp. 651-6, (2005) (PubMed).

Nagata, Nagase, Kawane, Mukae, Fukuyama: "Degradation of chromosomal DNA during apoptosis." in: Cell death and differentiation, Vol. 10, Issue 1, pp. 108-16, (2003) (PubMed).

Yoshida, Urasaki, Waltham, Bergman, Pourquier, Rothwell, Inuzuka, Weinstein, Ueda, Appella, Hickson, Pommier: "Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37768-76, (2003) (PubMed).

Wid?ak: "The DFF40/CAD endonuclease and its role in apoptosis." in: Acta biochimica Polonica, Vol. 47, Issue 4, pp. 1037-44, (2002) (PubMed).

Liu, Zou, Widlak, Garrard, Wang: "Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1." in: The Journal of biological chemistry, Vol. 274, Issue 20, pp. 13836-40, (1999) (PubMed).

Enari, Sakahira, Yokoyama, Okawa, Iwamatsu, Nagata: "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." in: Nature, Vol. 391, Issue 6662, pp. 43-50, (1998) (PubMed).

Liu, Li, Widlak, Zou, Luo, Garrard, Wang: "The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 15, pp. 8461-6, (1998) (PubMed).

Aliases for DFFB 抗体

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) 抗体
DNA fragmentation factor subunit beta (DFFB) 抗体
DNA fragmentation factor, beta polypeptide (caspase-activated DNase) (dffb) 抗体
DNA fragmentation factor subunit beta (LOC100223514) 抗体
DNA fragmentation factor, beta subunit (Dffb) 抗体
DNA fragmentation factor subunit beta (Dffb) 抗体
40kDa 抗体
5730477D02Rik 抗体
CAD 抗体
Cad 抗体
CPAN 抗体
DFF-40 抗体
DFF2 抗体
DFF40 抗体
Didff 抗体
LOC100223514 抗体
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