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The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (显示 DNMT1 ELISA试剂盒)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (显示 DNMT1 ELISA试剂盒)-linked chains are presented.
Thrombin (显示 F2 ELISA试剂盒)-mediated MALT1 (显示 MALT1 ELISA试剂盒) protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage.
SPATA2 has been described as a previously unrecognized factor in the linear ubiquitin chain assembly complex-dependent signaling pathways that serves as an adaptor between HOIP (显示 RNF31 ELISA试剂盒) and CYLD, thereby enabling recruitment of CYLD to signaling complexes.
TLR4 (显示 TLR4 ELISA试剂盒) activates CASPASE-8 (显示 CASP8 ELISA试剂盒) to cleave and remove the deubiquitinase cylindromatosis (CYLD) in a TRIF (显示 RNF138 ELISA试剂盒)- and RIPK1 (显示 RIPK1 ELISA试剂盒)-dependent manner to disable necroptosis in macrophages.
CYLD contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 (显示 NOX4 ELISA试剂盒) and may play a role in vascular remodeling.
this study shows that by polarization of the T cell cytokine response, CYLD can favor the development of allergic airway disease
Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis
Deubiquitinase CYLD negatively regulates MyD88 (显示 MYD88 ELISA试剂盒)-mediated signaling by directly interacting with MyD88 (显示 MYD88 ELISA试剂盒) and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 (显示 MYD88 ELISA试剂盒) at lysine 231.
CYLD interrupts the ERK (显示 EPHB2 ELISA试剂盒)- and p38 (显示 CRK ELISA试剂盒)-/AP-1 (显示 JUN ELISA试剂盒) and c-Myc (显示 MYC ELISA试剂盒) pathways to suppress Nrf2 (显示 NFE2L2 ELISA试剂盒)-operated antioxidative capacity, thereby enhancing oxidative stress in the heart.
Our data demonstrate that inefficient negative selection in the thymus of CYLD(ex7/8) mice result from a defect in mTEC maturation.
The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.
MiR (显示 MLXIP ELISA试剂盒)-767 acted as a role of tumor promoter by targeting CYLD in human melanoma.
The data reveal SPATA2 as a high-affinity binding partner of CYLD and HOIP (显示 RNF31 ELISA试剂盒), and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling.
The current investigations identified a subset of HPV-positive HNSCCs with mutations in the genes TRAF3 (显示 TRAF3 ELISA试剂盒) (tumor necrosis factor (显示 TNF ELISA试剂盒) receptor-associated factor 3) and CYLD (cylindromatosis lysine 63 deubiquitinase). Defects in TRAF3 (显示 TRAF3 ELISA试剂盒) and CYLD correlated with the activation of transcriptional factor nuclear factor kappaB, episomal HPV status of tumors, and improved patient survival.
The predicted PUB domain in the N-terminus of SPATA2 interacts with the USP domain of CYLD and SPATA2 is required for recruitment of CYLD to the TNF-alpha receptor-associated signaling complexes.
STAT3 (显示 STAT3 ELISA试剂盒) and miR (显示 MLXIP ELISA试剂盒)-181b control each other's expression in a positive feedback loop that regulates SFCs via CYLD pathway.
CYLD Promotes TNF-alpha (显示 TNF ELISA试剂盒)-Induced Cell Necrosis Mediated by RIP-1 in Human Lung Cancer Cells
Low CYLD expression is associated with hepatocellular carcinoma.
miR20a directly repressed the expression of CYLD, leading to activation of the NFkappaB (显示 NFKB1 ELISA试剂盒) pathway and the downstream targets, livin (显示 BIRC7 ELISA试剂盒) and survivin (显示 BIRC5 ELISA试剂盒), which potentially induced GC chemoresistance.
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
deubiquitinating enzyme CYLD
, probable ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin specific peptidase like 2
, ubiquitin thioesterase CYLD
, ubiquitin thiolesterase CYLD
, ubiquitin-specific-processing protease CYLD
, cylindromatosis (turban tumor syndrome)
, probable ubiquitin carboxyl-terminal hydrolase CYLD-like
, retinitis pigmentosa 1 homolog